t(8;17)(q12;p11) NCOR1/LYN

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
NCOR1
Location
17p12
Gene name
LYN
Location
8q12.1

Highly cited references

Pubmed IDYearTitleCitations
271767952016Characterization of pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia with kinase fusions in Japan.23
264048922015Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion.12
322661422020Rapid Molecular Response to Dasatinib in a Pediatric Relapsed Acute Lymphoblastic Leukemia With NCOR1-LYN Fusion.3
331998372021Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model.0
344972002021[Assessment of the leukemogenic mechanism of Ph-like acute lymphocytic leukemia for the identification of a novel therapeutic target].0

Bibliography

Pubmed IDLast YearTitleAuthors
264048922015Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion.Yano M et al

Summary

Fusion gene

NCOR1/LYN NCOR1 (17p12) LYN (8q12.1)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

t(8;17)(q12;p11) NCOR1/LYN

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2998/t(8;17)(q12;p11)-ncor1-lyn