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t(8;19)(p11;q13) KAT6A/LEUTX

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2856

Clinics and Pathology

Disease Acute myelomonocytic leukemia (FAB type M4)

Genes involved and Proteins

Gene NameKAT6A
Location 8p11.21
Gene NameLEUTX
Location 19q13.2

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy-related acute myeloid leukemia with t(8;19)(p11;q13)
Chinen Y, Taki T, Tsutsumi Y, Kobayashi S, Matsumoto Y, Sakamoto N, Kuroda J, Horiike S, Nishida K, Ohno H, Uike N, Taniwaki M
Genes Chromosomes Cancer 2014 Apr;53(4):299-308
PMID 24446090
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(8;19)(p11;q13) KAT6A/LEUTX

External links

KAT6A (8p11.21) LEUTX (19q13.2)

Mitelman databaset(8;19)(p11;q13) [Case List]    t(8;19)(p11;q13) [Transloc-MCList] KAT6A/LEUTX [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:22:03 CET 2018


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