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t(8;21)(q23;q22) RUNX1/TRPS1

Written2018-01Jean-Loup Huret, Philippe Dessen

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Atlas_Id 3444
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute myelomonocytic leukemia (FAB type M4)

Genes involved and Proteins

Gene NameRUNX1
Location 21q22.12
Gene NameTRPS1
Location 8q23.3


Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia
Asou N, Yanagida M, Huang L, Yamamoto M, Shigesada K, Mitsuya H, Ito Y, Osato M
Blood 2007 May 1;109(9):4023-7
PMID 17244685

Translocations implicated (Data extracted from papers in the Atlas)

 t(8;21)(q23;q22) RUNX1/TRPS1

External links

RUNX1 (21q22.12) TRPS1 (8q23.3)

Mitelman databaset(8;21)(q23;q22) [Case List]    t(8;21)(q23;q22) [Transloc-MCList] RUNX1/TRPS1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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