Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(8;22)(q24;q11) IGL/PVT1

Written2018-01Jean-Loup Huret, Philippe Dessen

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Atlas_Id 2830

Clinics and Pathology

Disease Burkitt lymphoma/leukemia

Genes involved and Proteins

Gene NameIGL
Location 19q13.41
Gene NamePVT1
Location 8q24.21

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma
Onciu M, Schlette E, Zhou Y, Raimondi SC, Giles FJ, Kantarjian HM, Medeiros LJ, Ribeiro RC, Pui CH, Sandlund JT
Cancer 2006 Sep 1;107(5):1084-92
PMID 16862570
Effects of translocations on transcription from PVT
Shtivelman E, Bishop JM
Mol Cell Biol 1990 Apr;10(4):1835-9
PMID 2181290
Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma
Shtivelman E, Henglein B, Groitl P, Lipp M, Bishop JM
Proc Natl Acad Sci U S A 1989 May;86(9):3257-60
PMID 2470097
Differential expression of the normal and of the translocated human c-myc oncogenes in B cells
Nishikura K, ar-Rushdi A, Erikson J, Watt R, Rovera G, Croce CM
Proc Natl Acad Sci U S A 1983 Aug;80(15):4822-6
PMID 6308654
Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma
Magrath I, Erikson J, Whang-Peng J, Sieverts H, Armstrong G, Benjamin D, Triche T, Alabaster O, Croce CM
Science 1983 Dec 9;222(4628):1094-8
PMID 6316501
Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas
Dalla-Favera R, Martinotti S, Gallo RC, Erikson J, Croce CM
Science 1983 Feb 25;219(4587):963-7
PMID 6401867
Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt
Croce CM, Thierfelder W, Erikson J, Nishikura K, Finan J, Lenoir GM, Nowell PC
Proc Natl Acad Sci U S A 1983 Nov;80(22):6922-6
PMID 6417658
A variant translocation places the lambda immunoglobulin genes 3' to the c-myc oncogene in Burkitt's lymphoma
Hollis GF, Mitchell KF, Battey J, Potter H, Taub R, Lenoir GM, Leder P
Nature 1984 Feb 23-29;307(5953):752-5
PMID 6422306

Translocations implicated (Data extracted from papers in the Atlas)

 t(8;22)(q24;q11) IGL/PVT1

External links

IGL (19q13.41) PVT1 (8q24.21)

Mitelman databaset(8;22)(q24;q11) [Case List]    t(8;22)(q24;q11) [Transloc-MCList] IGL/PVT1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Jan 10 17:22:04 CET 2018

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