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t(9;11)(p21;q23) KMT2A/MLLT3

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3448
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Acute megakaryoblastic leukemia (FAB type M7)|Acute monoblastic leukemia (FAB type M5)|Acute monoblastic leukemia with differentiation (FAB type M5b)|Acute monoblastic leukemia without differentiation (FAB type M5a)|Acute myeloblastic leukemia with minimal differentiation (FAB type M0)|Acute myeloblastic leukemia without maturation (FAB type M1)|Acute myeloid leukemia, NOS|Acute myelomonocytic leukemia (FAB type M4)|Myelodysplastic syndrome, NOS|Nonneoplastic hematologic disorder/lesion

Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameMLLT3
Location 9p21.3

Bibliography

Cryptic insertion of MLL gene into 9p22 leads to MLL-MLLT3 (AF9) fusion in a case of acute myelogenous leukemia
Shago M, Bouman D, Kamel-Reid S, Minden M, Chun K
Genes Chromosomes Cancer 2004 Aug;40(4):349-54
PMID 15188459
 
Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia
Negrini M, Felix CA, Martin C, Lange BJ, Nakamura T, Canaani E, Croce CM
Cancer Res 1993 Oct 1;53(19):4489-92
PMID 8402620
 
MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13
Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R
Oncogene 1993 Nov;8(11):3085-92
PMID 8414510
 
Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia
Super HG, Strissel PL, Sobulo OM, Burian D, Reshmi SC, Roe B, Zeleznik-Le NJ, Diaz MO, Rowley JD
Genes Chromosomes Cancer 1997 Oct;20(2):185-95
PMID 9331569
 
Stability of leukemia-associated aberrant immunophenotypes in patients with acute myeloid leukemia between diagnosis and relapse: comparison with cytomorphologic, cytogenetic, and molecular genetic findings
Voskova D, Schoch C, Schnittger S, Hiddemann W, Haferlach T, Kern W
Cytometry B Clin Cytom 2004 Nov;62(1):25-38
PMID 15468339
 
Three-way translocation involves MLL, MLLT3, and a novel cell cycle control gene, FLJ10374, in the pathogenesis of acute myeloid leukemia with t(9;11;19)(p22;q23;p13
Vieira L, Sousa AC, Matos P, Marques B, Alaiz H, Ribeiro MJ, Braga P, da Silva MG, Jordan P
3) Genes Chromosomes Cancer
PMID 16450356
 
Acute myelomonocytic leukemia after treatment with chronic oral etoposide: are MLL and LTG9 genes targets for etoposide? Int J Hematol
Goto H, Shimazaki C, Tatsumi T, Yamagata N, Inaba T, Fujita N, Moriguchi T, Yamamoto K, Seto M, Ueda R, et al
1994 Aug;60(2):145-9 PubMed PMID: 7948964
PMID 7948964
 
A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities
Yamamoto K, Seto M, Iida S, Komatsu H, Kamada N, Kojima S, Kodera Y, Nakazawa S, Saito H, Takahashi T, et al
Blood 1994 May 15;83(10):2912-21
PMID 8180386
 
MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13
Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R
Oncogene 1993 Nov;8(11):3085-92
PMID 8414510
 
MLL insertion with MLL-MLLT3 gene fusion in acute leukemia: case report and review of the literature
Soler G, Radford I, Meyer C, Marschalek R, Brouzes C, Ghez D, Romana S, Berger R
Cancer Genet Cytogenet 2008 May;183(1):53-9
PMID 18474298
 
A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities
Yamamoto K, Seto M, Iida S, Komatsu H, Kamada N, Kojima S, Kodera Y, Nakazawa S, Saito H, Takahashi T, et al
Blood 1994 May 15;83(10):2912-21
PMID 8180386
 
Incidence and characterization of MLL gene (11q23) rearrangements in acute myeloid leukemia M1 and M5
Poirel H, Rack K, Delabesse E, Radford-Weiss I, Troussard X, Debert C, Leboeuf D, Bastard C, Picard F, Veil-Buzyn A, Flandrin G, Bernard O, Macintyre E
Blood 1996 Mar 15;87(6):2496-505
PMID 8630416
 
Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial
Rubnitz JE, Inaba H, Dahl G, Ribeiro RC, Bowman WP, Taub J, Pounds S, Razzouk BI, Lacayo NJ, Cao X, Meshinchi S, Degar B, Airewele G, Raimondi SC, Onciu M, Coustan-Smith E, Downing JR, Leung W, Pui CH, Campana D
Lancet Oncol 2010 Jun;11(6):543-52
PMID 20451454
 
Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: a study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group
Gröschel S, Schlenk RF, Engelmann J, Rockova V, Teleanu V, Kühn MW, Eiwen K, Erpelinck C, Havermans M, Lübbert M, Germing U, Schmidt-Wolf IG, Beverloo HB, Schuurhuis GJ, Ossenkoppele GJ, Schlegelberger B, Verdonck LF, Vellenga E, Verhoef G, Vandenberghe P, Pabst T, Bargetzi M, Krauter J, Ganser A, Valk PJ, Löwenberg B, Döhner K, Döhner H, Delwel R
J Clin Oncol 2013 Jan 1;31(1):95-103
PMID 23008312
 
The landscape and therapeutic relevance of cancer-associated transcript fusions
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG
Oncogene 2015 Sep 10;34(37):4845-54
PMID 25500544
 
Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs
Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al
Proc Natl Acad Sci U S A 1993 May 15;90(10):4631-5
PMID 8506309
 
Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation
Joh T, Kagami Y, Yamamoto K, Segawa T, Takizawa J, Takahashi T, Ueda R, Seto M
Oncogene 1996 Nov 7;13(9):1945-53
PMID 8934541
 
Identification of MLL partner genes in 27 patients with acute leukemia from a single cytogenetic laboratory
De Braekeleer E, Meyer C, Douet-Guilbert N, Basinko A, Le Bris MJ, Morel F, Berthou C, Marschalek R, Férec C, De Braekeleer M
Mol Oncol 2011 Dec;5(6):555-63
PMID 21900057
 
Multiple clonal MLL fusions in a patient receiving CHOP-based chemotherapy
Shih SJ, Fass J, Buffalo V, Lin D, Singh SP, Diaz MO, Vaughan AT
Br J Haematol 2012 Oct;159(1):50-7
PMID 22845170
 
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models
Thiollier C, Lopez CK, Gerby B, Ignacimouttou C, Poglio S, Duffourd Y, Guégan J, Rivera-Munoz P, Bluteau O, Mabialah V, Diop M, Wen Q, Petit A, Bauchet AL, Reinhardt D, Bornhauser B, Gautheret D, Lecluse Y, Landman-Parker J, Radford I, Vainchenker W, Dastugue N, de Botton S, Dessen P, Bourquin JP, Crispino JD, Ballerini P, Bernard OA, Pflumio F, Mercher T
J Exp Med 2012 Oct 22;209(11):2017-31
PMID 23045605
 
NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern
de Rooij JD, Hollink IH, Arentsen-Peters ST, van Galen JF, Berna Beverloo H, Baruchel A, Trka J, Reinhardt D, Sonneveld E, Zimmermann M, Alonzo TA, Pieters R, Meshinchi S, van den Heuvel-Eibrink MM, Zwaan CM
Leukemia 2013 Dec;27(12):2280-8
PMID 23531517
 
Acute lymphoblastic leukemia with mature B-cell phenotype and t(9;11;11)(p22;q23;p11
Kim B, Lee ST, Kim HJ, Lee SH, Yoo KH, Koo HH, Kim SH
2): a case study and literature review Ann Lab Med
PMID 24624357
 
A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities
Yamamoto K, Seto M, Iida S, Komatsu H, Kamada N, Kojima S, Kodera Y, Nakazawa S, Saito H, Takahashi T, et al
Blood 1994 May 15;83(10):2912-21
PMID 8180386
 
Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs
Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al
Proc Natl Acad Sci U S A 1993 May 15;90(10):4631-5
PMID 8506309
 
A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities
Yamamoto K, Seto M, Iida S, Komatsu H, Kamada N, Kojima S, Kodera Y, Nakazawa S, Saito H, Takahashi T, et al
Blood 1994 May 15;83(10):2912-21
PMID 8180386
 
MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13
Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R
Oncogene 1993 Nov;8(11):3085-92
PMID 8414510
 
Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23)
Matsuo Y, MacLeod RA, Uphoff CC, Drexler HG, Nishizaki C, Katayama Y, Kimura G, Fujii N, Omoto E, Harada M, Orita K
Leukemia 1997 Sep;11(9):1469-77
PMID 9305600
 
Myelodysplastic syndromes associated with 11q23 abnormalities
Bain BJ, Moorman AV, Johansson B, Mehta AB, Secker-Walker LM
European 11q23 Workshop participants Leukemia
PMID 9593289
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(9;11)(p21;q23) KMT2A/MLLT3

External links

KMT2A (11q23.3) MLLT3 (9p21.3)

Mitelman databaset(9;11)(p21;q23) [Case List]    t(9;11)(p21;q23) [Transloc-MCList] KMT2A/MLLT3 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 28 18:21:07 CEST 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.