t(9;12)(p24;p13) ATF7IP/JAK2

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
ATF7IP
Location
12p13.1
Gene name
JAK2
Location
9p24.1

Highly cited references

Pubmed IDYearTitleCitations
294877122018Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome-like acute B-cell lymphoblastic leukemia.16
343767822021Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia.3

Bibliography

Pubmed IDLast YearTitleAuthors
278240512016Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.Gu Z et al

Summary

Fusion gene

ATF7IP/JAK2 ATF7IP (12p13.1) JAK2 (9p24.1)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Citation

Philippe Dessen ; Jean-Loup Huret

t(9;12)(p24;p13) ATF7IP/JAK2

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2531/t(9;12)(p24;p13)-atf7ip-jak2