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t(9;14)(p13;q32) IGH/PAX5

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2808

Clinics and Pathology

Disease Diffuse large B-cell lymphoma:Lymphoplasmacytic lymphoma:Mature B-cell neoplasm, NOS:Primary effusion lymphoma:Splenic marginal zone B-cell lymphoma:Waldenstràm macroglobulinemia

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NamePAX5
Location 9p13.2

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32)
Iida S, Rao PH, Ueda R, Chaganti RS, Dalla-Favera R
Leuk Lymphoma 1999 Jun;34(1-2):25-33
PMID 10350329
 
Lack of PAX5 rearrangements in lymphoplasmacytic lymphomas: reassessing the reported association with t(9;14)
Cook JR, Aguilera NI, Reshmi-Skarja S, Huang X, Yu Z, Gollin SM, Abbondanzo SL, Swerdlow SH
Hum Pathol 2004 Apr;35(4):447-54
PMID 15116325
 
The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene
Iida S, Rao PH, Nallasivam P, Hibshoosh H, Butler M, Louie DC, Dyomin V, Ohno H, Chaganti RS, Dalla-Favera R
Blood 1996 Dec 1;88(11):4110-7
PMID 8943844
 
t(9;14)(p13;q32) denotes a subset of low-grade non-Hodgkin's lymphoma with plasmacytoid differentiation
Offit K, Parsa NZ, Filippa D, Jhanwar SC, Chaganti RS
Blood 1992 Nov 15;80(10):2594-9
PMID 1384792
 
Molecular analysis of a chromosomal translocation, t(9;14)(p13;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1 antigen
Ohno H, Furukawa T, Fukuhara S, Zong SQ, Kamesaki H, Shows TB, Le Beau MM, McKeithan TW, Kawakami T, Honjo T
Proc Natl Acad Sci U S A 1990 Jan;87(2):628-32
PMID 2153959
 
A case of primary splenic large cell lymphoma with a t(9;14)(p13;q32)
Kawakami K, Amakawa R, Miyanishi S, Okumura A, Hayashi T, Kurata M, Ohno H, Ohno Y, Fukuhara S
Int J Hematol 1998 Feb;67(2):191-8
PMID 9631587
 
Expression of the PAX5/BSAP transcription factor in haematological tumour cells and further molecular characterization of the t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma
Hamada T, Yonetani N, Ueda C, Maesako Y, Akasaka H, Akasaka T, Ohno H, Kawakami K, Amakawa R, Okuma M
Br J Haematol 1998 Aug;102(3):691-700
PMID 9722295
 
PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements
Poppe B, De Paepe P, Michaux L, Dastugue N, Bastard C, Herens C, Moreau E, Cavazzini F, Yigit N, Van Limbergen H, De Paepe A, Praet M, De Wolf-Peeters C, Wlodarska I, Speleman F
Genes Chromosomes Cancer 2005 Oct;44(2):218-23
PMID 15942942
 
Translocation t(9;14)(p13;q32) in cases of splenic marginal zone lymphoma
Baró C, Salido M, Domingo A, Granada I, Colomo L, Serrano S, Solé F
Haematologica 2006 Sep;91(9):1289-91
PMID 16956840
 
Deregulated PAX-5 transcription from a translocated IgH promoter in marginal zone lymphoma
Morrison AM, Jäger U, Chott A, Schebesta M, Haas OA, Busslinger M
Blood 1998 Nov 15;92(10):3865-78
PMID 9808580
 
Herpes virus type 8-negative primary effusion lymphoma associated with PAX-5 gene rearrangement and hepatitis C virus: a case report and review of the literature
Ichinohasama R, Miura I, Kobayashi N, Saitoh Y, DeCoteau JF, Saiki Y, Mori S, Kadin ME, Ooya K
Am J Surg Pathol 1998 Dec;22(12):1528-37
PMID 9850179
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(9;14)(p13;q32) IGH/PAX5

External links

IGH (14q32.33) PAX5 (9p13.2)

Mitelman databaset(9;14)(p13;q32) [Case List]    t(9;14)(p13;q32) [Transloc-MCList] IGH/PAX5 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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