t(9;17)(p24;q21) SPAG9/JAK2

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
Location
17q21.33
Gene name
Location
9p24.1

Highly cited references

Pubmed IDYearTitleCitations
259518112015Identification of SPAG9 as a novel JAK2 fusion partner gene in pediatric acute lymphoblastic leukemia with t(9;17)(p24;q21).6
358794052022The combination of ruxolitinib and Bcl-2/Mcl-1 inhibitors has a synergistic effect on leukemic cells carrying a SPAG9::JAK2 fusion.0

Bibliography

Pubmed IDLast YearTitleAuthors
259518112015Identification of SPAG9 as a novel JAK2 fusion partner gene in pediatric acute lymphoblastic leukemia with t(9;17)(p24;q21).Kawamura M et al

Summary

Fusion gene

SPAG9/JAK2 SPAG9 (17q21.33) JAK2 (9p24.1)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

t(9;17)(p24;q21) SPAG9/JAK2

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/3224/t(9;17)(p24;q21)-spag9-jak2