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t(9;22)(q34;q11) NUP214/XKR3

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3033

Clinics and Pathology

Disease Chronic myeloid leukemia, t(9;22)

Genes involved and Proteins

Gene NameNUP214
Location 9q34.13
Gene NameXKR3
Location 22q11.1

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


Chimeric transcript discovery by paired-end transcriptome sequencing
Maher CA, Palanisamy N, Brenner JC, Cao X, Kalyana-Sundaram S, Luo S, Khrebtukova I, Barrette TR, Grasso C, Yu J, Lonigro RJ, Schroth G, Kumar-Sinha C, Chinnaiyan AM
Proc Natl Acad Sci U S A 2009 Jul 28;106(30):12353-8
PMID 19592507
Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts
Levin JZ, Berger MF, Adiconis X, Rogov P, Melnikov A, Fennell T, Nusbaum C, Garraway LA, Gnirke A
Genome Biol 2009;10(10):R115
PMID 19835606
Impact of unbalanced minor route versus major route karyotypes at diagnosis on prognosis of CML
Fabarius A, Kalmanti L, Dietz CT, Lauseker M, Rinaldetti S, Haferlach C, Göhring G, Schlegelberger B, Jotterand M, Hanfstein B, Seifarth W, Hänel M, Köhne CH, Lindemann HW, Berdel WE, Staib P, Müller MC, Proetel U, Balleisen L, Goebeler ME, Dengler J, Falge C, Kanz L, Burchert A, Kneba M, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Brümmendorf TH, Edinger M, Hofmann WK, Pfirrmann M, Hasford J, Krause S, Hochhaus A, Saußele S, Hehlmann R; SAKK and the German CML Study Group
Ann Hematol 2015 Dec;94(12):2015-24
PMID 26385387
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
Shtivelman E, Lifshitz B, Gale RP, Canaani E
Nature 1985 Jun 13-19;315(6020):550-4
PMID 2989692
Structural organization of the bcr gene and its role in the Ph' translocation
Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G
Nature 1985 Jun 27-Jul 3;315(6022):758-61
PMID 2989703
Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome
Stam K, Heisterkamp N, Grosveld G, de Klein A, Verma RS, Coleman M, Dosik H, Groffen J
N Engl J Med 1985 Dec 5;313(23):1429-33
PMID 3864009
Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
Heisterkamp N, Stephenson JR, Groffen J, Hansen PF, de Klein A, Bartram CR, Grosveld G
Nature 1983 Nov 17-23;306(5940):239-42
PMID 6316147
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G
Cell 1984 Jan;36(1):93-9
PMID 6319012
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
de Klein A, van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, Spurr NK, Heisterkamp N, Groffen J, Stephenson JR
Nature 1982 Dec 23;300(5894):765-7
PMID 6960256

Translocations implicated (Data extracted from papers in the Atlas)

 t(9;22)(q34;q11) NUP214/XKR3

External links

NUP214 (9q34.13) XKR3 (22q11.1)

Mitelman databaset(9;22)(q34;q11) [Case List]    t(9;22)(q34;q11) [Transloc-MCList] NUP214/XKR3 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Jan 10 17:22:19 CET 2018

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