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t(9;22)(q34;q11) PRRC2B/BCR

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3118

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NamePRRC2B
Location 9q34.13
Gene NameBCR
Location 17p13.3

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Acute lymphoblastic leukemia
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Poor treatment outcome of Philadelphia chromosome-positive pediatric acute lymphoblastic leukemia despite intensive chemotherapy
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Clinical significance of cytogenetic findings at diagnosis and in remission in childhood and adult acute lymphoblastic leukemia: experience from India
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Cancer Genet Cytogenet 1999 Apr;110(1):44-53
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Prospective karyotype analysis in adult acute lymphoblastic leukemia: the cancer and leukemia Group B experience
Wetzler M, Dodge RK, Mrózek K, Carroll AJ, Tantravahi R, Block AW, Pettenati MJ, Le Beau MM, Frankel SR, Stewart CC, Szatrowski TP, Schiffer CA, Larson RA, Bloomfield CD
Blood 1999 Jun 1;93(11):3983-93
PMID 10339508
 
Clinical sensitivity to anthracyclines in PH/BCR+ acute lymphoblastic leukemia
Bassan R, Rohatiner AZ, Rambaldi A, Lerede T, Di Bona E, Carter M, Rossi G, Pogliani E, Lambertenghi-Deliliers G, Fabris P, Porcellini A, Lister TA, Barbui T
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PMID 10500826
 
Long-term follow-up of 23 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with allogeneic bone marrow transplant in first complete remission
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Leukemia 1999 Dec;13(12):2053-8
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Prognostic impact of karyotypic findings in childhood acute lymphoblastic leukaemia: a Nordic series comparing two treatment periods
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Prognostic factors in childhood acute lymphoblastic leukemia in Japan
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Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) acute lymphoblastic leukemia studies, 1982-1995
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Leukemia 2000 Dec;14(12):2196-204
PMID 11187911
 
Long-term follow-up of the United Kingdom Medical Research Council protocols for childhood acute lymphoblastic leukaemia, 1980-1997
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Medical Research Council Childhood Leukaemia Working Party Leukemia
PMID 11187922
 
Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol
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Br J Haematol 2001 Apr;113(1):103-14
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Acute lymphoblastic leukemia in the elderly: The Edouard Herriot Hospital experience
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Am J Hematol 2001 Jun;67(2):73-83
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Allogeneic bone marrow transplantation in first remission rescues children with Philadelphia chromosome-positive acute lymphoblastic leukemia: Tokyo Children's Cancer Study Group (TCCSG) studies L89-12 and L92-13
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Med Pediatr Oncol 2001 Nov;37(5):426-31
PMID 11745870
 
Prognostic value of karyotypic analysis in children and adults with high-risk acute lymphoblastic leukemia included in the PETHEMA ALL-93 trial
Ribera JM, Ortega JJ, Oriol A, Granada I, Hernández-Rivas JM, Parody R, Bethencourt C, Rivas C, Bastida P, del Potro E, González-Valentín ME, Moreno MJ, Besalduch J, Fernández-Calvo J, Tormo M, Arias J, Molinés A, Sanz MA, Maldonado J, Millá F, Feliu E, San Miguel JF; PETHEMA Group, Spanish Society of Hematology
Haematologica 2002 Feb;87(2):154-66
PMID 11836166
 
Influence of karyotype on outcome of allogeneic bone marrow transplantation for adults with precursor B-lineage acute lymphoblastic leukaemia in first or second remission
Lee S, Kim DW, Kim YJ, Park YH, Min CK, Lee JW, Min WS, Kim CC
Br J Haematol 2002 Apr;117(1):109-18
PMID 11918540
 
Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and acute leukemia: report from an international workshop
Block AW, Carroll AJ, Hagemeijer A, Michaux L, van Lom K, Olney HJ, Baer MR
Genes Chromosomes Cancer 2002 Apr;33(4):401-12
PMID 11921274
 
Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia
Linker C, Damon L, Ries C, Navarro W
J Clin Oncol 2002 May 15;20(10):2464-71
PMID 12011123
 
Acute lymphoblastic leukemia in elderly patients the Philadelphia chromosome may not be a significant adverse prognostic factor
Onciu M, Bueso-Ramos C, Medeiros LJ, Ball G, Smith T, Lai R
Am J Clin Pathol 2002 May;117(5):716-20
PMID 12090419
 
Improved outcome in high-risk childhood acute lymphoblastic leukemia defined by prednisone-poor response treated with double Berlin-Frankfurt-Muenster protocol II
Aricò M, Valsecchi MG, Conter V, Rizzari C, Pession A, Messina C, Barisone E, Poggi V, De Rossi G, Locatelli F, Micalizzi MC, Basso G, Masera G
Blood 2002 Jul 15;100(2):420-6
PMID 12091331
 
Induction therapy by frequent administration of doxorubicin with four other drugs, followed by intensive consolidation and maintenance therapy for adult acute lymphoblastic leukemia: the JALSG-ALL93 study
Takeuchi J, Kyo T, Naito K, Sao H, Takahashi M, Miyawaki S, Kuriyama K, Ohtake S, Yagasaki F, Murakami H, Asou N, Ino T, Okamoto T, Usui N, Nishimura M, Shinagawa K, Fukushima T, Taguchi H, Morii T, Mizuta S, Akiyama H, Nakamura Y, Ohshima T, Ohno R
Leukemia 2002 Jul;16(7):1259-66
PMID 12094249
 
Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia--results of the prospective multicenter LALA-94 trial
Dombret H, Gabert J, Boiron JM, Rigal-Huguet F, Blaise D, Thomas X, Delannoy A, Buzyn A, Bilhou-Nabera C, Cayuela JM, Fenaux P, Bourhis JH, Fegueux N, Charrin C, Boucheix C, Lhéritier V, Espérou H, MacIntyre E, Vernant JP, Fière D; Groupe d'Etude et de Traitement de la Leucémie Aiguë Lymphoblastique de l'Adulte (GET-LALA Group)
Blood 2002 Oct 1;100(7):2357-66
PMID 12239143
 
Additional chromosomal abnormalities and variability of BCR breakpoints in Philadelphia chromosome/BCR-ABL-positive acute lymphoblastic leukemia in Taiwan
Ko BS, Tang JL, Lee FY, Liu MC, Tsai W, Chen YC, Wang CH, Sheng MC, Lin DT, Lin KH, Tien HF
Am J Hematol 2002 Dec;71(4):291-9
PMID 12447959
 
Clinico-biologic features and treatment outcome of adult pro-B-ALL patients enrolled in the GIMEMA 0496 study: absence of the ALL1/AF4 and of the BCR/ABL fusion genes correlates with a significantly better clinical outcome
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Blood 2003 Sep 15;102(6):2014-20
PMID 12791662
 
Allogeneic hematopoietic cell transplantation for patients with high-risk acute lymphoblastic leukemia in first or second complete remission using fractionated total-body irradiation and high-dose etoposide: a 15-year experience
Jamieson CH, Amylon MD, Wong RM, Blume KG
Exp Hematol 2003 Oct;31(10):981-6
PMID 14550815
 
Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762)
Westbrook CA, Hooberman AL, Spino C, Dodge RK, Larson RA, Davey F, Wurster-Hill DH, Sobol RE, Schiffer C, Bloomfield CD
Blood 1992 Dec 15;80(12):2983-90
PMID 1467514
 
The role of allogeneic bone marrow transplantation in adult patients below the age of 55 years with acute lymphoblastic leukemia in first complete remission: a donor vs no donor comparison
Gupta V, Yi QL, Brandwein J, Minden MD, Schuh AC, Wells RA, Chun K, Kamel-Reid S, Tsang R, Daly A, Kiss T, Lipton JH, Messner HA
Bone Marrow Transplant 2004 Feb;33(4):397-404
PMID 14688816
 
Additional cytogenetic abnormalities in adults with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a study of the Cancer and Leukaemia Group B
Wetzler M, Dodge RK, Mrózek K, Stewart CC, Carroll AJ, Tantravahi R, Vardiman JW, Larson RA, Bloomfield CD
Br J Haematol 2004 Feb;124(3):275-88
PMID 14717774
 
Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome
Heerema NA, Harbott J, Galimberti S, Camitta BM, Gaynon PS, Janka-Schaub G, Kamps W, Basso G, Pui CH, Schrappe M, Auclerc MF, Carroll AJ, Conter V, Harrison CJ, Pullen J, Raimondi SC, Richards S, Riehm H, Sather HN, Shuster JJ, Silverman LB, Valsecchi MG, Aricò M; Acute Lymphoblastic Leukemia Study Groups; ALL-BFM; CoALL; AIEOP; DCLSG; FRALLE; CCG; DFCI; POG; St Jude; UKALL
Leukemia 2004 Apr;18(4):693-702
PMID 15044926
 
Clinical and prognostic significance of the Philadelphia chromosome in adult patients with acute lymphoblastic leukemia
Götz G, Weh HJ, Walter TA, Kuse R, Kolbe K, Dölken G, Hellriegel KP, Hoelzer D, Hossfeld DK
Ann Hematol 1992 Feb;64(2):97-100
PMID 1554802
 
A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): analysis of the GIMEMA 0496 protocol
Mancini M, Scappaticci D, Cimino G, Nanni M, Derme V, Elia L, Tafuri A, Vignetti M, Vitale A, Cuneo A, Castoldi G, Saglio G, Pane F, Mecucci C, Camera A, Specchia G, Tedeschi A, Di Raimondo F, Fioritoni G, Fabbiano F, Marmont F, Ferrara F, Cascavilla N, Todeschini G, Nobile F, Kropp MG, Leoni P, Tabilio A, Luppi M, Annino L, Mandelli F, Foà R
Blood 2005 May 1;105(9):3434-41
PMID 15650057
 
Genetic heterogeneity of BCR/ABL+ adult B-cell precursor acute lymphoblastic leukemia: impact on the clinical, biological and immunophenotypical disease characteristics
Primo D, Tabernero MD, Perez JJ, Rasillo A, Sayagués JM, Espinosa AB, Lopez-Berges MC, García-Sanz R, Gutierrez NC, Hernandez JM, Romero M, Osuna CS, Giralt M, Barbon M, San Miguel JF, Orfao A
Leukemia 2005 May;19(5):713-20
PMID 15789066
 
Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: results of the Medical Research Council ALL 97 trial
Roy A, Bradburn M, Moorman AV, Burrett J, Love S, Kinsey SE, Mitchell C, Vora A, Eden T, Lilleyman JS, Hann I, Saha V; Medical Research Council Childhood Leukaemia Working Party
Br J Haematol 2005 Apr;129(1):35-44
PMID 15801953
 
Autologous and allogeneic stem cell transplantation in adult ALL: the Swedish Adult ALL Group experience
Hallböök H, Hägglund H, Stockelberg D, Nilsson PG, Karlsson K, Björkholm M, Linderholm M, Wahlin A, Linder O, Smedmyr B; Swedish Adult ALL Group
Bone Marrow Transplant 2005 Jun;35(12):1141-8
PMID 15834433
 
Having a higher blast percentage in circulation than bone marrow: clinical implications in myelodysplastic syndrome and acute lymphoid and myeloid leukemias
Amin HM, Yang Y, Shen Y, Estey EH, Giles FJ, Pierce SA, Kantarjian HM, O'Brien SM, Jilani I, Albitar M
Leukemia 2005 Sep;19(9):1567-72
PMID 16049515
 
Outcome of treatment in adults with Philadelphia chromosome-positive and/or BCR-ABL--positive acute lymphoblastic leukemia-retrospective analysis of Polish Adult Leukemia Group (PALG)
Wrzesień-Kuś A, Robak T, Pluta A, Zwolińska M, Wawrzyniak E, Wierzbowska A, Skotnicki A, Jakubas B, Hołowiecki J, Nowak K, Kuliczkowski K, Mazur G, Haus O, Dmoszyńska A, Adamczyk-Cioch M, Jedrzejczak WW, Paluszewska M, Konopka L, Pałynyczko G
Ann Hematol 2006 Jun;85(6):366-73
PMID 16523310
 
Initial and late prognostic factors to predict survival in adult acute lymphoblastic leukaemia
Le QH, Thomas X, Ecochard R, Iwaz J, Lhéritier V, Michallet M, Fiere D
Eur J Haematol 2006 Dec;77(6):471-9
PMID 16978239
 
Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG)
Schultz KR, Pullen DJ, Sather HN, Shuster JJ, Devidas M, Borowitz MJ, Carroll AJ, Heerema NA, Rubnitz JE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Gaynon PS, Camitta BM
Blood 2007 Feb 1;109(3):926-35
PMID 17003380
 
Prospective multicentric molecular study for poor prognosis fusion transcripts at diagnosis in adult B-lineage ALL patients: the LALA 94 experience
Picard C, Hayette S, Bilhou-Nabera C, Cayuela JM, Delabesse E, Frenoy N, Preudhomme C, Dupont M, Bastard C, Bories D, Vaerman JL, Davi F, Dastugue N, Raynaud S, Lafage M, Deschaseaux F, Fest T, Gaub MP, Lhéritier V, Thomas X, Charrin C, Boucheix C, Dombret H, Macintyre E, Fière D, Gabert J
Leukemia 2006 Dec;20(12):2178-81
PMID 17039237
 
Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
Moorman AV, Harrison CJ, Buck GA, Richards SM, Secker-Walker LM, Martineau M, Vance GH, Cherry AM, Higgins RR, Fielding AK, Foroni L, Paietta E, Tallman MS, Litzow MR, Wiernik PH, Rowe JM, Goldstone AH, Dewald GW; Adult Leukaemia Working Party, Medical Research Council/National Cancer Research Institute
Blood 2007 Apr 15;109(8):3189-97
PMID 17170120
 
Allogeneic bone marrow transplantation in first remission for children with ultra-high-risk features of acute lymphoblastic leukemia: A children's oncology group study report
Satwani P, Sather H, Ozkaynak F, Heerema NA, Schultz KR, Sanders J, Kersey J, Davenport V, Trigg M, Cairo MS
Biol Blood Marrow Transplant 2007 Feb;13(2):218-27
PMID 17241927
 
Proportion of long-term event-free survivors and lifetime of adult patients not cured after a standard acute lymphoblastic leukemia therapeutic program: adult acute lymphoblastic leukemia-94 trial
Le QH, Thomas X, Ecochard R, Iwaz J, Lhéritier V, Michallet M, Fiere D
Cancer 2007 May 15;109(10):2058-67
PMID 17407135
 
Long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: favorable outcome with BMT at first remission and HLA-matched unrelated donor
Chim CS, Lie AK, Liang R, Au WY, Kwong YL
Bone Marrow Transplant 2007 Aug;40(4):339-47
PMID 17572712
 
Impact of cytogenetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group 9400 study
Pullarkat V, Slovak ML, Kopecky KJ, Forman SJ, Appelbaum FR
Blood 2008 Mar 1;111(5):2563-72
PMID 18156492
 
Karyotype at diagnosis is the major prognostic factor predicting relapse-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy
Yanada M, Takeuchi J, Sugiura I, Akiyama H, Usui N, Yagasaki F, Nishii K, Ueda Y, Takeuchi M, Miyawaki S, Maruta A, Narimatsu H, Miyazaki Y, Ohtake S, Jinnai I, Matsuo K, Naoe T, Ohno R; Japan Adult Leukemia Study Group
Haematologica 2008 Feb;93(2):287-90
PMID 18223280
 
[Chromosome aberrations in acute leukemia in childhood: analysis of 1009 patients]
Lampert F, Harbott J, Ritterbach J
Klin Padiatr 1991 Jul-Aug;203(4):311-8
PMID 1834889
 
Prognostic factors for leukemic induction failure in children with acute lymphoblastic leukemia and outcome after salvage therapy: the FRALLE 93 study
Oudot C, Auclerc MF, Levy V, Porcher R, Piguet C, Perel Y, Gandemer V, Debre M, Vermylen C, Pautard B, Berger C, Schmitt C, Leblanc T, Cayuela JM, Socie G, Michel G, Leverger G, Baruchel A
J Clin Oncol 2008 Mar 20;26(9):1496-503
PMID 18349402
 
Acute lymphoblastic leukemia in adolescents and young adults in Finland
Usvasalo A, Räty R, Knuutila S, Vettenranta K, Harila-Saari A, Jantunen E, Kauppila M, Koistinen P, Parto K, Riikonen P, Salmi TT, Silvennoinen R, Elonen E, Saarinen-Pihkala UM
Haematologica 2008 Aug;93(8):1161-8
PMID 18556413
 
The application of conventional cytogenetics, FISH, and RT-PCR to detect genetic changes in 70 children with ALL
Soszynska K, Mucha B, Debski R, Skonieczka K, Duszenko E, Koltan A, Wysocki M, Haus O
Ann Hematol 2008 Dec;87(12):991-1002
PMID 18633615
 
Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival
Kumar P, Defor TE, Brunstein C, Barker JN, Wagner JE, Weisdorf DJ, Burns LJ
Biol Blood Marrow Transplant 2008 Dec;14(12):1394-400
PMID 19041062
 
Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL)
Bassan R, Spinelli O, Oldani E, Intermesoli T, Tosi M, Peruta B, Rossi G, Borlenghi E, Pogliani EM, Terruzzi E, Fabris P, Cassibba V, Lambertenghi-Deliliers G, Cortelezzi A, Bosi A, Gianfaldoni G, Ciceri F, Bernardi M, Gallamini A, Mattei D, Di Bona E, Romani C, Scattolin AM, Barbui T, Rambaldi A
Blood 2009 Apr 30;113(18):4153-62
PMID 19141862
 
Additional chromosomal abnormalities and their prognostic significance in adult Philadelphia-positive acute lymphoblastic leukemia: with or without imatinib in chemotherapy
Li Y, Qiu L, Zou D, Zhao Y, Mi Y, Wang J
Ann Hematol 2009 Nov;88(11):1069-77
PMID 19277658
 
Significance of the P210 versus P190 molecular abnormalities in adults with Philadelphia chromosome-positive acute leukemia
Kantarjian HM, Talpaz M, Dhingra K, Estey E, Keating MJ, Ku S, Trujillo J, Huh Y, Stass S, Kurzrock R
Blood 1991 Nov 1;78(9):2411-8
PMID 1932753
 
Impact of chromosomal translocations on prognosis in childhood acute lymphoblastic leukemia
Rubin CM, Le Beau MM, Mick R, Bitter MA, Nachman J, Rudinsky R, Appel HJ, Morgan E, Suarez CR, Schumacher HR, et al
J Clin Oncol 1991 Dec;9(12):2183-92
PMID 1960559
 
Outcome of childhood acute lymphoblastic leukemia with induction failure treated by the Japan Association of Childhood Leukemia study (JACLS) ALL F-protocol
Suzuki N, Yumura-Yagi K, Yoshida M, Hara J, Nishimura S, Kudoh T, Tawa A, Usami I, Tanizawa A, Hori H, Ito Y, Miyaji R, Oda M, Kato K, Hamamoto K, Osugi Y, Hashii Y, Nakahata T, Horibe K; Japan Association of Childhood Leukemia Study (JACLS)
Pediatr Blood Cancer 2010 Jan;54(1):71-8
PMID 19813250
 
Detection and clinical relevance of BCR-ABL fusion gene in childhood T-lineage acute lymphoblastic leukemia: a report on 4 cases
Sazawal S, Bakhshi S, Raina V, Swaroop C, Saxena R
J Pediatr Hematol Oncol 2009 Nov;31(11):850-2
PMID 19816207
 
A population-based cytogenetic study of adults with acute lymphoblastic leukemia
Moorman AV, Chilton L, Wilkinson J, Ensor HM, Bown N, Proctor SJ
Blood 2010 Jan 14;115(2):206-14
PMID 19897583
 
Translocation (9;22) is associated with extremely poor prognosis in intensively treated children with acute lymphoblastic leukemia
Fletcher JA, Lynch EA, Kimball VM, Donnelly M, Tantravahi R, Sallan SE
Blood 1991 Feb 1;77(3):435-9
PMID 1991160
 
Philadelphia chromosome and monosomy 7 in childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study
Russo C, Carroll A, Kohler S, Borowitz M, Amylon M, Homans A, Kedar A, Shuster J, Land V, Crist W, et al
Blood 1991 Mar 1;77(5):1050-6
PMID 1995090
 
Chromosomes in childhood acute lymphoblastic leukaemia: karyotypic patterns in disease subtypes
Wodzinski MA, Watmore AE, Lilleyman JS, Potter AM
J Clin Pathol 1991 Jan;44(1):48-51
PMID 1997533
 
Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia
Pui CH, Pei D, Sandlund JT, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Campana D, Kun LE, Jeha S, Cheng C, Howard SC, Metzger ML, Bhojwani D, Downing JR, Evans WE, Relling MV
Leukemia 2010 Feb;24(2):371-82
PMID 20010620
 
Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001
Mitchell C, Richards S, Harrison CJ, Eden T
Leukemia 2010 Feb;24(2):406-18
PMID 20010621
 
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia
Schmiegelow K, Forestier E, Hellebostad M, Heyman M, Kristinsson J, Söderhäll S, Taskinen M; Nordic Society of Paediatric Haematology and Oncology
Leukemia 2010 Feb;24(2):345-54
PMID 20010622
 
Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the children's oncology group
Salzer WL, Devidas M, Carroll WL, Winick N, Pullen J, Hunger SP, Camitta BA
Leukemia 2010 Feb;24(2):355-70
PMID 20016527
 
Long-term results of the Israeli National Studies in childhood acute lymphoblastic leukemia: INS 84, 89 and 98
Stark B, Nirel R, Avrahami G, Abramov A, Attias D, Ballin A, Bielorai B, Burstein Y, Gavriel H, Elhasid R, Kapelushnik J, Sthoeger D, Toren A, Wientraub M, Yaniv I, Izraeli S
Leukemia 2010 Feb;24(2):419-24
PMID 20016534
 
Long-term results of treatment of childhood acute lymphoblastic leukemia in the Czech Republic
Stary J, Jabali Y, Trka J, Hrusak O, Gajdos P, Hrstkova H, Sterba J, Blazek B, Hak J, Prochazkova D, Cerna Z, Smisek P, Sedlacek P, Vavra V, Mihal V, Hrodek O; Czech Pediatric Hematology working group
Leukemia 2010 Feb;24(2):425-8
PMID 20016535
 
Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia
Liang DC, Yang CP, Lin DT, Hung IJ, Lin KH, Chen JS, Hsiao CC, Chang TT, Peng CT, Lin MT, Chang TK, Jaing TH, Liu HC, Wang LY, Yeh TC, Jou ST, Lu MY, Cheng CN, Sheen JM, Chiou SS, Wu KH, Hung GY, Chen RL, Chen SH, Cheng SN, Chang YH, Chen BW, Ho WL, Wang JL, Lin ST, Hsieh YL, Wang SC, Chang HH, Yang YL, Huang FL, Chang CY, Chang WH, Lin KS
Leukemia 2010 Feb;24(2):397-405
PMID 20016538
 
Long-term results of Tokyo Children's Cancer Study Group trials for childhood acute lymphoblastic leukemia, 1984-1999
Tsuchida M, Ohara A, Manabe A, Kumagai M, Shimada H, Kikuchi A, Mori T, Saito M, Akiyama M, Fukushima T, Koike K, Shiobara M, Ogawa C, Kanazawa T, Noguchi Y, Oota S, Okimoto Y, Yabe H, Kajiwara M, Tomizawa D, Ko K, Sugita K, Kaneko T, Maeda M, Inukai T, Goto H, Takahashi H, Isoyama K, Hayashi Y, Hosoya R, Hanada R; Tokyo Children's Cancer Study Group
Leukemia 2010 Feb;24(2):383-96
PMID 20033052
 
Philadelphia positive acute lymphoblastic leukemia in adults: age distribution, BCR breakpoint and prognostic significance
Secker-Walker LM, Craig JM, Hawkins JM, Hoffbrand AV
Leukemia 1991 Mar;5(3):196-9
PMID 2013979
 
Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial
Moorman AV, Ensor HM, Richards SM, Chilton L, Schwab C, Kinsey SE, Vora A, Mitchell CD, Harrison CJ
Lancet Oncol 2010 May;11(5):429-38
PMID 20409752
 
Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: a report from the Children's Oncology Group
Maloney KW, Carroll WL, Carroll AJ, Devidas M, Borowitz MJ, Martin PL, Pullen J, Whitlock JA, Willman CL, Winick NJ, Camitta BM, Hunger SP
Blood 2010 Aug 19;116(7):1045-50
PMID 20442364
 
Chimeric BCR-abl messenger RNA as a marker for minimal residual disease in patients transplanted for Philadelphia chromosome-positive acute lymphoblastic leukemia
Gehly GB, Bryant EM, Lee AM, Kidd PG, Thomas ED
Blood 1991 Jul 15;78(2):458-65
PMID 2070081
 
Prognostic significance of immunophenotypic and karyotypic features of Philadelphia positive B-lymphoblastic leukemia in the era of tyrosine kinase inhibitors
Jaso J, Thomas DA, Cunningham K, Jorgensen JL, Kantarjian HM, Medeiros LJ, Wang SA
Cancer 2011 Sep 1;117(17):4009-17
PMID 21365622
 
Allogeneic hematopoietic stem cell transplantation for Philadelphia-positive acute lymphoblastic leukemia in children and adolescents: a retrospective multicenter study of the Italian Association of Pediatric Hematology and Oncology (AIEOP)
Fagioli F, Zecca M, Rognoni C, Lanino E, Balduzzi A, Berger M, Messina C, Favre C, Rabusin M, Lo Nigro L, Masetti R, Prete A, Locatelli F; AIEOP-HSCT Group
Biol Blood Marrow Transplant 2012 Jun;18(6):852-60
PMID 22019726
 
The importance of cytogenetic studies in adult acute lymphocytic leukemia
Walters R, Kantarjian HM, Keating MJ, Estey EH, Trujillo J, Cork A, McCredie KB, Freireich EJ
Am J Med 1990 Nov;89(5):579-87
PMID 2239977
 
Outcomes after induction failure in childhood acute lymphoblastic leukemia
Schrappe M, Hunger SP, Pui CH, Saha V, Gaynon PS, Baruchel A, Conter V, Otten J, Ohara A, Versluys AB, Escherich G, Heyman M, Silverman LB, Horibe K, Mann G, Camitta BM, Harbott J, Riehm H, Richards S, Devidas M, Zimmermann M
N Engl J Med 2012 Apr 12;366(15):1371-81
PMID 22494120
 
Clinical features, early treatment responses, and outcomes of pediatric acute lymphoblastic leukemia in China with or without specific fusion transcripts: a single institutional study of 1,004 patients
Gao C, Zhao XX, Li WJ, Cui L, Zhao W, Liu SG, Yue ZX, Jiao Y, Wu MY, Li ZG
Am J Hematol 2012 Nov;87(11):1022-7
PMID 22911440
 
Lack of negative impact of Philadelphia chromosome in older patients with acute lymphoblastic leukaemia in the thyrosine kinase inhibitor era: comparison of two prospective parallel protocols
Ribera JM, García O, Fernández-Abellán P, Lavilla E, Bernal MT, González-Campos J, Brunet S, Monteserín MC, Montesinos P, Sarrá J, Calbacho M, Alvarez-Larrán A, Tormo M, Oriol A; PETHEMA Group
Br J Haematol 2012 Nov;159(4):485-8
PMID 22966847
 
Philadelphia chromosome positive childhood acute lymphoblastic leukemia: clinical and cytogenetic characteristics and treatment outcome
Crist W, Carroll A, Shuster J, Jackson J, Head D, Borowitz M, Behm F, Link M, Steuber P, Ragab A, et al
A Pediatric Oncology Group study Blood
PMID 2378982
 
Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: impact of tyrosine kinase inhibitor and minimal residual disease
Bachanova V, Marks DI, Zhang MJ, Wang H, de Lima M, Aljurf MD, Arellano M, Artz AS, Bacher U, Cahn JY, Chen YB, Copelan EA, Drobyski WR, Gale RP, Greer JP, Gupta V, Hale GA, Kebriaei P, Lazarus HM, Lewis ID, Lewis VA, Liesveld JL, Litzow MR, Loren AW, Miller AM, Norkin M, Oran B, Pidala J, Rowe JM, Savani BN, Saber W, Vij R, Waller EK, Wiernik PH, Weisdorf DJ
Leukemia 2014 Mar;28(3):658-65
PMID 23989431
 
Autologous transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia achieves outcomes similar to allogeneic transplantation: results of CALGB Study 10001 (Alliance)
Wetzler M, Watson D, Stock W, Koval G, Mulkey FA, Hoke EE, McCarty JM, Blum WG, Powell BL, Marcucci G, Bloomfield CD, Linker CA, Larson RA
Haematologica 2014 Jan;99(1):111-5
PMID 24077846
 
Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease
Roberts KG, Pei D, Campana D, Payne-Turner D, Li Y, Cheng C, Sandlund JT, Jeha S, Easton J, Becksfort J, Zhang J, Coustan-Smith E, Raimondi SC, Leung WH, Relling MV, Evans WE, Downing JR, Mullighan CG, Pui CH
J Clin Oncol 2014 Sep 20;32(27):3012-20
PMID 25049327
 
Long-term outcome of a pediatric-inspired regimen used for adults aged 18-50 years with newly diagnosed acute lymphoblastic leukemia
DeAngelo DJ, Stevenson KE, Dahlberg SE, Silverman LB, Couban S, Supko JG, Amrein PC, Ballen KK, Seftel MD, Turner AR, Leber B, Howson-Jan K, Kelly K, Cohen S, Matthews JH, Savoie L, Wadleigh M, Sirulnik LA, Galinsky I, Neuberg DS, Sallan SE, Stone RM
Leukemia 2015 Mar;29(3):526-34
 
Prognostic factors for outcome in patients with refractory and relapsed acute lymphocytic leukemia treated with inotuzumab ozogamicin, a CD22 monoclonal antibody
Jabbour E, O'Brien S, Huang X, Thomas D, Rytting M, Sasaki K, Cortes J, Garcia-Manero G, Kadia T, Ravandi F, Pierce S, Kantarjian H
Am J Hematol 2015 Mar;90(3):193-6
PMID 25407953
 
Therapy-related ALL: cytogenetic features and hematopoietic cell transplantation outcome
Aldoss I, Dagis A, Palmer J, Forman S, Pullarkat V
Bone Marrow Transplant 2015 May;50(5):746-8
PMID 25730188
 
Impact of Additional Cytogenetic Abnormalities in Adults with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation
Aldoss I, Stiller T, Cao TM, Palmer JM, Thomas SH, Forman SJ, Pullarkat V
Biol Blood Marrow Transplant 2015 Jul;21(7):1326-9
 
Long-term follow-up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
Ravandi F, O'Brien SM, Cortes JE, Thomas DM, Garris R, Faderl S, Burger JA, Rytting ME, Ferrajoli A, Wierda WG, Verstovsek S, Champlin R, Kebriaei P, McCue DA, Huang X, Jabbour E, Garcia-Manero G, Estrov Z, Kantarjian HM
Cancer 2015 Dec 1;121(23):4158-64
PMID 26308885
 
The Philadelphia chromosome (Ph1) in adults presenting with acute leukaemia: a comparison of Ph1+ and Ph1-patients
Bloomfield CD, Peterson LC, Yunis JJ, Brunning RD
Br J Haematol 1977 Jul;36(3):347-58
PMID 268208
 
Cytogenetics and their prognostic value in childhood and adult acute lymphoblastic leukemia (ALL) excluding L3
Fenaux P, Lai JL, Morel P, Nelken B, Taboureau O, Deminatti M, Bauters F
Hematol Oncol 1989 Jul-Aug;7(4):307-17
PMID 2737611
 
Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia
Liu YF, Wang BY, Zhang WN, Huang JY, Li BS, Zhang M, Jiang L, Li JF, Wang MJ, Dai YJ, Zhang ZG, Wang Q, Kong J, Chen B, Zhu YM, Weng XQ, Shen ZX, Li JM, Wang J, Yan XJ, Li Y, Liang YM, Liu L, Chen XQ, Zhang WG, Yan JS, Hu JD, Shen SH, Chen J, Gu LJ, Pei D, Li Y, Wu G, Zhou X, Ren RB, Cheng C, Yang JJ, Wang KK, Wang SY, Zhang J, Mi JQ, Pui CH, Tang JY, Chen Z, Chen SJ
EBioMedicine 2016 Jun;8:173-183
PMID 27428428
 
Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia
Bloomfield CD, Secker-Walker LM, Goldman AI, Van Den Berghe H, de la Chapelle A, Ruutu T, Alimena G, Garson OM, Golomb HM, Rowley JD, et al
Cancer Genet Cytogenet 1989 Jul 15;40(2):171-85
PMID 2766242
 
Prognostic implications of cytogenetic studies in an intensively treated group of children with acute lymphoblastic leukemia
Fletcher JA, Kimball VM, Lynch E, Donnelly M, Pavelka K, Gelber RD, Tantravahi R, Sallan SE
Blood 1989 Nov 1;74(6):2130-5
PMID 2804351
 
Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia
Hermans A, Heisterkamp N, von Linden M, van Baal S, Meijer D, van der Plas D, Wiedemann LM, Groffen J, Bootsma D, Grosveld G
Cell 1987 Oct 9;51(1):33-40
PMID 2820585
 
Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia
Pui CH, Williams DL, Roberson PK, Raimondi SC, Behm FG, Lewis SH, Rivera GK, Kalwinsky DK, Abromowitch M, Crist WM, et al
J Clin Oncol 1988 Jan;6(1):56-61
PMID 2961852
 
A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia
Chan LC, Karhi KK, Rayter SI, Heisterkamp N, Eridani S, Powles R, Lawler SD, Groffen J, Foulkes JG, Greaves MF, Wiedemann LM
Nature 1987 Feb 12-18;325(6105):635-7
PMID 3027581
 
Nonrandom chromosomal abnormalities in acute lymphoblastic leukemia of childhood
Prigogina EL, Puchkova GP, Mayakova SA
Cancer Genet Cytogenet 1988 Jun;32(2):183-203
PMID 3163259
 
Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia
Ribeiro RC, Abromowitch M, Raimondi SC, Murphy SB, Behm F, Williams DL
Blood 1987 Oct;70(4):948-53
PMID 3307953
 
Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia
Bloomfield CD, Goldman AI, Alimena G, Berger R, Borgström GH, Brandt L, Catovsky D, de la Chapelle A, Dewald GW, Garson OM, et al
Blood 1986 Feb;67(2):415-20
PMID 3455828
 
Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukemia
Williams DL, Harber J, Murphy SB, Look AT, Kalwinsky DK, Rivera G, Melvin SL, Stass S, Dahl GV
Blood 1986 Jul;68(1):205-12
PMID 3459555
 
bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia
De Klein A, Hagemeijer A, Bartram CR, Houwen R, Hoefsloot L, Carbonell F, Chan L, Barnett M, Greaves M, Kleihauer E, et al
Blood 1986 Dec;68(6):1369-75
PMID 3465378
 
Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia
Walker LC, Ganesan TS, Dhut S, Gibbons B, Lister TA, Rothbard J, Young BD
Nature 1987 Oct 29-Nov 4;329(6142):851-3
PMID 3478595
 
Multiple molecular abnormalities in Ph1 chromosome positive acute lymphoblastic leukaemia
Dreazen O, Klisak I, Jones G, Ho WG, Sparkes RS, Gale RP
Br J Haematol 1987 Nov;67(3):319-24
PMID 3479997
 
Monosomy 7 and Ph-positive acute lymphoblastic leukaemia: cytogenetic and molecular aspects
Eridani S, Gorman P, Sheer D, Duncombe AS, Glass UH, Shivji MK
Leuk Res 1987;11(11):965-9
PMID 3480400
 
Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia
Erikson J, Griffin CA, ar-Rushdi A, Valtieri M, Hoxie J, Finan J, Emanuel BS, Rovera G, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1986 Mar;83(6):1807-11
PMID 3513189
 
Philadelphia chromosome-positive adult acute leukemia with monosomy of chromosome number seven: a subgroup with poor response to therapy
Maddox AM, Keating MJ, Trujillo J, Cork A, Youness E, Ahearn MJ, McCredie KB, Freireich EJ
Leuk Res 1983;7(4):509-22
PMID 6578392
 
Philadelphia chromosome positive childhood acute lymphoblastic leukemia
Priest JR, Robison LL, McKenna RW, Lindquist LL, Warkentin PI, LeBien TW, Woods WG, Kersey JH, Coccia PF, Nesbit ME Jr
Blood 1980 Jul;56(1):15-22
PMID 6930307
 
Chromosomal abnormalities in acute lymphoblastic leukemia
Bloomfield CD, Lindquist LL, Arthur D, McKenna RW, LeBien TW, Nesbit ME, Peterson BA
Cancer Res 1981 Nov;41(11 Pt 2):4838-43
PMID 7028252
 
Cytogenetic correlation with disease status and treatment outcome in advanced stage leukemia post bone marrow transplantation: a Southwest Oncology Group study (SWOG-8612)
Slovak ML, Kopecky KJ, Wolman SR, Henslee-Downey JP, Appelbaum FR, Forman SJ, Blume KG
Leuk Res 1995 Jun;19(6):381-8
PMID 7596150
 
Clinical significance of chromosome abnormalities in childhood acute lymphoblastic leukemia in Japan
Kobayashi H, Maseki N, Homma C, Sakurai M, Kaneko Y
Leukemia 1994 Nov;8(11):1944-50
PMID 7967740
 
Minor myeloid component in Ph chromosome-positive acute lymphoblastic leukaemia: correlation with cytogenetic pattern and implication for poor response to therapy
Cuneo A, Demuynck H, Ferrant A, Louwagie A, Doyen C, Stul M, Cassiman JJ, Dal Cin P, Negrini M, Carli MG, et al
Br J Haematol 1994 Jul;87(3):515-22
PMID 7993791
 
Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients
Preti HA, O'Brien S, Giralt S, Beran M, Pierce S, Kantarjian HM
Am J Med 1994 Jul;97(1):60-5
PMID 8030658
 
Simultaneous expression of RBTN-2 and BCR-ABL oncogenes in a T-ALL with a t(11;14)(p13;q11) and a late-appearing Philadelphia chromosome
Fizzotti M, Chen EY, Link MP, Carroll AJ, Foroni L, Rabbitts TH, Crist WM, Clark SS
Leukemia 1994 Jul;8(7):1124-30
PMID 8035604
 
Detection and significance of bcr-abl mRNA transcripts and fusion proteins in Philadelphia-positive adult acute lymphoblastic leukemia
Tuszynski A, Dhut S, Young BD, Lister TA, Rohatiner AZ, Amess JA, Chaplin T, Dorey E, Gibbons B
Leukemia 1993 Oct;7(10):1504-8
PMID 8412311
 
Groupe Français de Cytogénétique Hématologique
Collaborative study of karyotypes in childhood acute lymphoblastic leukemias
Leukemia 1993 Jan;7(1):10-9
PMID 8418369
 
Prognostic implications of breakpoint and lineage heterogeneity in Philadelphia-positive acute lymphoblastic leukemia: a review
Secker-Walker LM, Craig JM
Leukemia 1993 Feb;7(2):147-51
PMID 8426467
 
A Collaborative Study of the Group Français de Cytogénétique Hématologique
Cytogenetic abnormalities in adult acute lymphoblastic leukemia: correlations with hematologic findings outcome
Blood 1996 Apr 15;87(8):3135-42
PMID 8605327
 
Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL)
Schlieben S, Borkhardt A, Reinisch I, Ritterbach J, Janssen JW, Ratei R, Schrappe M, Repp R, Zimmermann M, Kabisch H, Janka-Schaub G, Bartram CR, Ludwig WD, Riehm H, Lampert F, Harbott J
A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92 Leukemia
 
Prognostic significance of additional chromosome abnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukaemia
Rieder H, Ludwig WD, Gassmann W, Maurer J, Janssen JW, Gökbuget N, Schwartz S, Thiel E, Löffler H, Bartram CR, Hoelzer D, Fonatsch C
Br J Haematol 1996 Dec;95(4):678-91
PMID 8982045
 
Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA
Secker-Walker LM, Prentice HG, Durrant J, Richards S, Hall E, Harrison G
MRC Adult Leukaemia Working Party Br J Haematol
PMID 9054669
 
Philadelphia chromosome in relapsed childhood acute lymphoblastic leukemia: a matched-pair analysis
Beyermann B, Adams HP, Henze G
Berlin-Frankfurt-Münster Study Group J Clin Oncol
PMID 9196135
 
Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: a Children's Cancer Group initiative
Gaynon PS, Crotty ML, Sather HN, Bostrom BC, Nachman JB, Steinherz PG, Heerema NA, Sarquis M, Tuel-Ahlgren L, Uckun FM
Leuk Lymphoma 1997 Jun;26(1-2):57-65
PMID 9250788
 
Genetic studies of childhood acute lymphoblastic leukemia with emphasis on p16, MLL, and ETV6 gene abnormalities: results of St Jude Total Therapy Study XII
Rubnitz JE, Behm FG, Pui CH, Evans WE, Relling MV, Raimondi SC, Harrison PL, Sandlund JT, Ribeiro RC, Grosveld G, Downing JR
Leukemia 1997 Aug;11(8):1201-6
PMID 9264370
 
Philadelphia chromosome-positive acute lymphoblastic leukemia in children: durable responses to chemotherapy associated with low initial white blood cell counts
Ribeiro RC, Broniscer A, Rivera GK, Hancock ML, Raimondi SC, Sandlund JT, Crist W, Evans WE, Pui CH
Leukemia 1997 Sep;11(9):1493-6
PMID 9305603
 
Cytogenetics and prognosis in childhood lymphoblastic leukaemia: results of MRC UKALL X
Chessels JM, Swansbury GJ, Reeves B, Bailey CC, Richards SM
Medical Research Council Working Party in Childhood Leukaemia Br J Haematol
PMID 9359508
 
Philadelphia chromosome positive adult acute lymphoblastic leukemia: characteristics, prognostic factors and treatment outcome
Thomas X, Thiebaut A, Olteanu N, Danaïla C, Charrin C, Archimbaud E, Fiere D
Hematol Cell Ther 1998 Jun;40(3):119-28
PMID 9698220
 
Critical study of prognostic factors in childhood acute lymphoblastic leukaemia: differences in outcome are poorly explained by the most significant prognostic variables
Donadieu J, Auclerc MF, Baruchel A, Leblanc T, Landman-Parker J, Perel Y, Michel G, Cornu G, Bordigoni P, Sommelet D, Leverger G, Hill C, Schaison G
Fralle group French Acute Lymphoblastic Leukaemia study group
PMID 9722300
 
Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: good initial steroid response allows early prediction of a favorable treatment outcome
Schrappe M, Aricò M, Harbott J, Biondi A, Zimmermann M, Conter V, Reiter A, Valsecchi MG, Gadner H, Basso G, Bartram CR, Lampert F, Riehm H, Masera G
Blood 1998 Oct 15;92(8):2730-41
PMID 9763557
 
Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies: a report from the Children's Cancer Group
Uckun FM, Nachman JB, Sather HN, Sensel MG, Kraft P, Steinherz PG, Lange B, Hutchinson R, Reaman GH, Gaynon PS, Heerema NA
Cancer 1998 Nov 1;83(9):2030-9
PMID 9806664
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(9;22)(q34;q11) PRRC2B/BCR

External links

PRRC2B (9q34.13) BCR (17p13.3)

Mitelman databaset(9;22)(q34;q11) [Case List]    t(9;22)(q34;q11) [Transloc-MCList] PRRC2B/BCR [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
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