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t(10;11)(p12;q23) MLLT10/CEP164

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2962

Clinics and Pathology

Disease Acute monoblastic leukemia (FAB type M5)

Genes involved and Proteins

Gene NameMLLT10
Location 10p12.31
Gene NameCEP164
Location 11q23.3

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
Cancer Genome Atlas Research Network, Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G
N Engl J Med 2013 May 30;368(22):2059-74
PMID 23634996
 
The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene
Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD
Blood 1995 Sep 15;86(6):2073-6
PMID 7662954
 
A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia
Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD
Blood 1995 Mar 15;85(6):1435-41
PMID 7888665
 
Prevalence and clinical correlations of MLL gene rearrangements in AML-M4/5
Bower M, Parry P, Carter M, Lillington DM, Amess J, Lister TA, Evans G, Young BD
Blood 1994 Dec 1;84(11):3776-80
PMID 7949133
 
Structure and expression of the human trithorax-like gene 1 involved in acute leukemias
Parry P, Djabali M, Bower M, Khristich J, Waterman M, Gibbons B, Young BD, Evans G
Proc Natl Acad Sci U S A 1993 May 15;90(10):4738-42
PMID 8506328
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(10;11)(p12;q23) MLLT10/CEP164

External links

MLLT10 (10p12.31) CEP164 (11q23.3)

Mitelman databaset(10;11)(p12;q23) [Case List]    t(10;11)(p12;q23) [Transloc-MCList] MLLT10/CEP164 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Fri Feb 23 20:24:39 CET 2018


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