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ins(10;11)(p12;q23q23)|ins(11;10)(q23;p12p12)|t(10;11)(p12;q23) KMT2A/MLLT10

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3464
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Acute megakaryoblastic leukemia (FAB type M7)|Acute monoblastic leukemia (FAB type M5)|Acute monoblastic leukemia with differentiation (FAB type M5b)|Acute monoblastic leukemia without differentiation (FAB type M5a)|Acute myeloblastic leukemia with maturation (FAB type M2)|Acute myeloblastic leukemia with minimal differentiation (FAB type M0)|Acute myeloblastic leukemia without maturation (FAB type M1)|Acute myeloid leukemia, NOS|Acute myelomonocytic leukemia (FAB type M4)|Bilineage or biphenotypic leukemia

Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameMLLT10
Location 10p12.31

Bibliography

Protean clinical manifestations in children with leukemias containing MLL-AF10 fusion
Gore L, Ess J, Bitter MA, McGavran L, Meltesen L, Wei Q, Hunger SP
Leukemia 2000 Dec;14(12):2070-5
PMID 11187895
 
t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines
Shibuya N, Taki T, Mugishima H, Chin M, Tsuchida M, Sako M, Kawa K, Ishii E, Miura I, Yanagisawa M, Hayashi Y
Genes Chromosomes Cancer 2001 Sep;32(1):1-10
PMID 11477655
 
Cytogenetics, fluorescence in situ hybridization, and reverse transcriptase polymerase chain reaction are necessary to clarify the various mechanisms leading to an MLL-AF10 fusion in acute myelocytic leukemia with 10;11 rearrangement
Klaus M, Schnittger S, Haferlach T, Dreyling M, Hiddemann W, Schoch C
Cancer Genet Cytogenet 2003 Jul 1;144(1):36-43
PMID 12810254
 
A novel type of MLL/AF10 fusion transcript in a child with acute megakaryocytic leukemia (AML-M7)
Borkhardt A, Haas OA, Strobl W, Repp R, Mann G, Gadner H, Lampert F
Leukemia 1995 Oct;9(10):1796-7
PMID 7564531
 
The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene
Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD
Blood 1995 Sep 15;86(6):2073-6
PMID 7662954
 
The t(10;11)(p12;q23) translocation in acute leukaemia: a cytogenetic and clinical study of 20 patients
Lillington DM, Young BD, Berger R, Martineau M, Moorman AV, Secker-Walker LM
European 11q23 Workshop participants Leukemia
PMID 9593284
 
MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis
Dreyling MH, Schrader K, Fonatsch C, Schlegelberger B, Haase D, Schoch C, Ludwig W, Löffler H, Büchner T, Wörmann B, Hiddemann W, Bohlander SK
Blood 1998 Jun 15;91(12):4662-7
PMID 9616163
 
Protean clinical manifestations in children with leukemias containing MLL-AF10 fusion
Gore L, Ess J, Bitter MA, McGavran L, Meltesen L, Wei Q, Hunger SP
Leukemia 2000 Dec;14(12):2070-5
PMID 11187895
 
Cytogenetics, fluorescence in situ hybridization, and reverse transcriptase polymerase chain reaction are necessary to clarify the various mechanisms leading to an MLL-AF10 fusion in acute myelocytic leukemia with 10;11 rearrangement
Klaus M, Schnittger S, Haferlach T, Dreyling M, Hiddemann W, Schoch C
Cancer Genet Cytogenet 2003 Jul 1;144(1):36-43
PMID 12810254
 
Protean clinical manifestations in children with leukemias containing MLL-AF10 fusion
Gore L, Ess J, Bitter MA, McGavran L, Meltesen L, Wei Q, Hunger SP
Leukemia 2000 Dec;14(12):2070-5
PMID 11187895
 
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, McCastlain K, Edmonson M, Pounds SB, Shi L, Zhou X, Ma X, Sioson E, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Auvil JG, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino BP, Downing JR, Loh ML, Hunger SP, Zhang J, Mullighan CG
Nat Genet 2017 Aug;49(8):1211-1218
PMID 28671688
 
Multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 29 translocations and chromosomal aberrations in acute leukemia
Pallisgaard N, Hokland P, Riishøj DC, Pedersen B, Jørgensen P
Blood 1998 Jul 15;92(2):574-88
PMID 9657758
 
t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines
Shibuya N, Taki T, Mugishima H, Chin M, Tsuchida M, Sako M, Kawa K, Ishii E, Miura I, Yanagisawa M, Hayashi Y
Genes Chromosomes Cancer 2001 Sep;32(1):1-10
PMID 11477655
 
Cryptic rearrangement involving MLL and AF10 occurring in utero
Jones LK, Neat MJ, van Delft FW, Mitchell MP, Adamaki M, Stoneham SJ, Patel N, Saha V
Leukemia 2003 Aug;17(8):1667-9
PMID 12886258
 
MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity
Morerio C, Rapella A, Rosanda C, Lanino E, Lo Nigro L, Di Cataldo A, Maserati E, Pasquali F, Panarello C
Cancer Genet Cytogenet 2004 Jul 15;152(2):108-12
PMID 15262427
 
Cryptic MLL-AF10 fusion caused by insertion of duplicated 5' part of MLL into 10p12 in acute leukemia: a case report
Jarosova M, Takacova S, Holzerova M, Priwitzerova M, Divoka M, Lakoma I, Mihal V, Indrak K, Divoky V
Cancer Genet Cytogenet 2005 Oct 15;162(2):179-82
PMID 16213369
 
The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene
Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD
Blood 1995 Sep 15;86(6):2073-6
PMID 7662954
 
A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia
Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD
Blood 1995 Mar 15;85(6):1435-41
PMID 7888665
 
AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12)
Tanabe S, Bohlander SK, Vignon CV, Espinosa R 3rd, Zhao N, Strissel PL, Zeleznik-Le NJ, Rowley JD
Blood 1996 Nov 1;88(9):3535-45
PMID 8896421
 
t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines
Shibuya N, Taki T, Mugishima H, Chin M, Tsuchida M, Sako M, Kawa K, Ishii E, Miura I, Yanagisawa M, Hayashi Y
Genes Chromosomes Cancer 2001 Sep;32(1):1-10
PMID 11477655
 
Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia
Matsuda K, Tanaka M, Araki S, Yanagisawa R, Yamauchi K, Koike K
Cancer Genet Cytogenet 2009 Apr 15;190(2):113-20
PMID 19380030
 
Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies
Andersson A, Höglund M, Johansson B, Lassen C, Billström R, Garwicz S, Nilsson PG, Mitelman F, Fioretos T
Leukemia 2001 Aug;15(8):1293-300
PMID 11480574
 
A case of infantile acute myelogenous leukemia with MLL-MLL10 fusion caused by insertion of 11q into 10p
Christiansen L, Allen RA, Dunn ST, Wolff DJ
Cancer Genet Cytogenet 2005 Jun;159(2):181-3
PMID 15899395
 
The landscape and therapeutic relevance of cancer-associated transcript fusions
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG
Oncogene 2015 Sep 10;34(37):4845-54
PMID 25500544
 
The t(10;11)(p12;q23) translocation in acute leukaemia: a cytogenetic and clinical study of 20 patients
Lillington DM, Young BD, Berger R, Martineau M, Moorman AV, Secker-Walker LM
European 11q23 Workshop participants Leukemia
PMID 9593284
 
MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis
Dreyling MH, Schrader K, Fonatsch C, Schlegelberger B, Haase D, Schoch C, Ludwig W, Löffler H, Büchner T, Wörmann B, Hiddemann W, Bohlander SK
Blood 1998 Jun 15;91(12):4662-7
PMID 9616163
 
Multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 29 translocations and chromosomal aberrations in acute leukemia
Pallisgaard N, Hokland P, Riishøj DC, Pedersen B, Jørgensen P
Blood 1998 Jul 15;92(2):574-88
PMID 9657758
 
Molecular cytogenetic analysis of 10;11 rearrangements in acute myeloid leukemia
Van Limbergen H, Poppe B, Janssens A, De Bock R, De Paepe A, Noens L, Speleman F
Leukemia 2002 Mar;16(3):344-51
PMID 11896537
 
A new rearrangement giving rise to a very rare MLL-MLLT10 fusion mRNA in an infant acute myeloid leukemia
Burillo-Sanz S, Morales-Camacho R, Vargas MT, Carrillo E, Pérez-Soto I, García-Lozano JR
Cancer Genet 2015 Mar;208(3):101-2
PMID 25475940
 
MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia
Morerio C, Rapella A, Tassano E, Rosanda C, Panarello C
Leuk Res 2005 Oct;29(10):1223-6
PMID 16111539
 
A novel type of MLL/AF10 fusion transcript in a child with acute megakaryocytic leukemia (AML-M7)
Borkhardt A, Haas OA, Strobl W, Repp R, Mann G, Gadner H, Lampert F
Leukemia 1995 Oct;9(10):1796-7
PMID 7564531
 
Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement
Shih LY, Liang DC, Fu JF, Wu JH, Wang PN, Lin TL, Dunn P, Kuo MC, Tang TC, Lin TH, Lai CL
Leukemia 2006 Feb;20(2):218-23
PMID 16341046
 
A case of acute myelogenous leukemia with MLL-AF10 fusion caused by insertion of 5' MLL into 10p12, with concurrent 3' MLL deletion
Matsuda K, Hidaka E, Ishida F, Yamauchi K, Makishima H, Ito T, Suzuki T, Imagawa E, Sano K, Katsuyama T, Ota H
Cancer Genet Cytogenet 2006 Nov;171(1):24-30
PMID 17074587
 
The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene
Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD
Blood 1995 Sep 15;86(6):2073-6
PMID 7662954
 
The t(10;11)(p12;q23) translocation in acute leukaemia: a cytogenetic and clinical study of 20 patients
Lillington DM, Young BD, Berger R, Martineau M, Moorman AV, Secker-Walker LM
European 11q23 Workshop participants Leukemia
PMID 9593284
 


Translocations implicated (Data extracted from papers in the Atlas)

 ins(10;11)(p12;q23q23)|ins(11;10)(q23;p12p12)|t(10;11)(p12;q23) KMT2A/MLLT10

External links

KMT2A (11q23.3) MLLT10 (10p12.31)

Mitelman databaseins(10;11)(p12;q23q23)|ins(11;10)(q23;p12p12)|t(10;11)(p12;q23) [Case List]    ins(10;11)(p12;q23q23)|ins(11;10)(q23;p12p12)|t(10;11)(p12;q23) [Transloc-MCList] KMT2A/MLLT10 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 28 18:21:27 CEST 2018


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