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t(10;11)(p12;q14)|t(10;11)(p12;q23) PICALM/MLLT10

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3465
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute eosinophilic leukemia|Acute lymphoblastic leukemia/lymphoblastic lymphoma|Acute megakaryoblastic leukemia (FAB type M7)|Acute monoblastic leukemia (FAB type M5)|Acute monoblastic leukemia without differentiation (FAB type M5a)|Acute myeloblastic leukemia with maturation (FAB type M2)|Acute myeloblastic leukemia with minimal differentiation (FAB type M0)|Acute myeloblastic leukemia without maturation (FAB type M1)|Acute myeloid leukemia, NOS|Acute myelomonocytic leukemia (FAB type M4)

Genes involved and Proteins

Gene NamePICALM
Gene NameMLLT10
Location 10p12.31

Bibliography

Mixed-lineage leukemia with t(10;11)(p13;q21): an analysis of AF10-CALM and CALM-AF10 fusion mRNAs and clinical features
Kumon K, Kobayashi H, Maseki N, Sakashita A, Sakurai M, Tanizawa A, Imashuku S, Kaneko Y
Genes Chromosomes Cancer 1999 May;25(1):33-9
PMID 10221337
 
Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts
Narita M, Shimizu K, Hayashi Y, Taki T, Taniwaki M, Hosoda F, Kobayashi H, Nakamura H, Sadamori N, Ohnishi H, Bessho F, Yanagisawa M, Ohki M
Br J Haematol 1999 Jun;105(4):928-37
PMID 10554802
 
Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients
Bohlander SK, Muschinsky V, Schrader K, Siebert R, Schlegelberger B, Harder L, Schemmel V, Fonatsch C, Ludwig WD, Hiddemann W, Dreyling MH
Leukemia 2000 Jan;14(1):93-9
PMID 10637482
 
Identification and molecular characterization of CALM/AF10fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia
Carlson KM, Vignon C, Bohlander S, Martinez-Climent JA, Le Beau MM, Rowley JD
Leukemia 2000 Jan;14(1):100-4
PMID 10637483
 
CALM-AF10 fusion gene in leukemias: simple and inversion-associated translocation (10;11)
Salmon-Nguyen F, Busson M, Daniel M, Leblanc T, Bernard OA, Berger R
Cancer Genet Cytogenet 2000 Oct 15;122(2):137-40
PMID 11106826
 
CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage
Asnafi V, Radford-Weiss I, Dastugue N, Bayle C, Leboeuf D, Charrin C, Garand R, Lafage-Pochitaloff M, Delabesse E, Buzyn A, Troussard X, Macintyre E
Blood 2003 Aug 1;102(3):1000-6
PMID 12676784
 
Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences
van Grotel M, Meijerink JP, van Wering ER, Langerak AW, Beverloo HB, Buijs-Gladdines JG, Burger NB, Passier M, van Lieshout EM, Kamps WA, Veerman AJ, van Noesel MM, Pieters R
Leukemia 2008 Jan;22(1):124-31
PMID 17928886
 
The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest
Ben Abdelali R, Asnafi V, Petit A, Micol JB, Callens C, Villarese P, Delabesse E, Reman O, Lepretre S, Cahn JY, Guillerm G, Berthon C, Gardin C, Corront B, Leguay T, Béné MC, Ifrah N, Leverger G, Dombret H, Macintyre E
Haematologica 2013 Nov;98(11):1711-7
PMID 23831922
 
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey RC, McCastlain K, Reshmi SC, Payne-Turner D, Iacobucci I, Shao Y, Chen IM, Valentine M, Pei D, Mungall KL, Mungall AJ, Ma Y, Moore R, Marra M, Stonerock E, Gastier-Foster JM, Devidas M, Dai Y, Wood B, Borowitz M, Larsen EE, Maloney K, Mattano LA Jr, Angiolillo A, Salzer WL, Burke MJ, Gianni F, Spinelli O, Radich JP, Minden MD, Moorman AV, Patel B, Fielding AK, Rowe JM, Luger SM, Bhatia R, Aldoss I, Forman SJ, Kohlschmidt J, Mrózek K, Marcucci G, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Paietta E, Willman CL, Loh ML, Hunger SP, Mullighan CG
Nat Commun 2016 Nov 8;7:13331
PMID 27824051
 
Hematologic malignancies with the t(10;11) (p13;q21) have the same molecular event and a variety of morphologic or immunologic phenotypes
Kobayashi H, Hosoda F, Maseki N, Sakurai M, Imashuku S, Ohki M, Kaneko Y
Genes Chromosomes Cancer 1997 Nov;20(3):253-9
PMID 9365832
 
Mixed-lineage leukemia with t(10;11)(p13;q21): an analysis of AF10-CALM and CALM-AF10 fusion mRNAs and clinical features
Kumon K, Kobayashi H, Maseki N, Sakashita A, Sakurai M, Tanizawa A, Imashuku S, Kaneko Y
Genes Chromosomes Cancer 1999 May;25(1):33-9
PMID 10221337
 
Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts
Narita M, Shimizu K, Hayashi Y, Taki T, Taniwaki M, Hosoda F, Kobayashi H, Nakamura H, Sadamori N, Ohnishi H, Bessho F, Yanagisawa M, Ohki M
Br J Haematol 1999 Jun;105(4):928-37
PMID 10554802
 
Hematologic malignancies with the t(10;11) (p13;q21) have the same molecular event and a variety of morphologic or immunologic phenotypes
Kobayashi H, Hosoda F, Maseki N, Sakurai M, Imashuku S, Ohki M, Kaneko Y
Genes Chromosomes Cancer 1997 Nov;20(3):253-9
PMID 9365832
 
Mixed-lineage leukemia with t(10;11)(p13;q21): an analysis of AF10-CALM and CALM-AF10 fusion mRNAs and clinical features
Kumon K, Kobayashi H, Maseki N, Sakashita A, Sakurai M, Tanizawa A, Imashuku S, Kaneko Y
Genes Chromosomes Cancer 1999 May;25(1):33-9
PMID 10221337
 
MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis
Dreyling MH, Schrader K, Fonatsch C, Schlegelberger B, Haase D, Schoch C, Ludwig W, Löffler H, Büchner T, Wörmann B, Hiddemann W, Bohlander SK
Blood 1998 Jun 15;91(12):4662-7
PMID 9616163
 
Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts
Narita M, Shimizu K, Hayashi Y, Taki T, Taniwaki M, Hosoda F, Kobayashi H, Nakamura H, Sadamori N, Ohnishi H, Bessho F, Yanagisawa M, Ohki M
Br J Haematol 1999 Jun;105(4):928-37
PMID 10554802
 
Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts
Narita M, Shimizu K, Hayashi Y, Taki T, Taniwaki M, Hosoda F, Kobayashi H, Nakamura H, Sadamori N, Ohnishi H, Bessho F, Yanagisawa M, Ohki M
Br J Haematol 1999 Jun;105(4):928-37
PMID 10554802
 
MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis
Dreyling MH, Schrader K, Fonatsch C, Schlegelberger B, Haase D, Schoch C, Ludwig W, Löffler H, Büchner T, Wörmann B, Hiddemann W, Bohlander SK
Blood 1998 Jun 15;91(12):4662-7
PMID 9616163
 
Identification and molecular characterization of CALM/AF10fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia
Carlson KM, Vignon C, Bohlander S, Martinez-Climent JA, Le Beau MM, Rowley JD
Leukemia 2000 Jan;14(1):100-4
PMID 10637483
 
PICALM-MLLT10 acute myeloid leukemia: a French cohort of 18 patients
Borel C, Dastugue N, Cances-Lauwers V, Mozziconacci MJ, Prebet T, Vey N, Pigneux A, Lippert E, Visanica S, Legrand F, Rault JP, Taviaux S, Bastard C, Mugneret F, Collonges Rames MA, Gachard N, Talmant P, Delabesse E, Récher C
Leuk Res 2012 Nov;36(11):1365-9
PMID 22871473
 
The landscape and therapeutic relevance of cancer-associated transcript fusions
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG
Oncogene 2015 Sep 10;34(37):4845-54
PMID 25500544
 
Hematologic malignancies with the t(10;11) (p13;q21) have the same molecular event and a variety of morphologic or immunologic phenotypes
Kobayashi H, Hosoda F, Maseki N, Sakurai M, Imashuku S, Ohki M, Kaneko Y
Genes Chromosomes Cancer 1997 Nov;20(3):253-9
PMID 9365832
 
MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis
Dreyling MH, Schrader K, Fonatsch C, Schlegelberger B, Haase D, Schoch C, Ludwig W, Löffler H, Büchner T, Wörmann B, Hiddemann W, Bohlander SK
Blood 1998 Jun 15;91(12):4662-7
PMID 9616163
 
CALM-AF10 fusion gene in leukemias: simple and inversion-associated translocation (10;11)
Salmon-Nguyen F, Busson M, Daniel M, Leblanc T, Bernard OA, Berger R
Cancer Genet Cytogenet 2000 Oct 15;122(2):137-40
PMID 11106826
 
Identification and molecular characterisation of a CALM-AF10 fusion in acute megakaryoblastic leukaemia
Jones LK, Chaplin T, Shankar A, Neat M, Patel N, Samuel DP, Hill AS, Debernardi S, Bassini A, Young BD, Saha V
Leukemia 2001 Jun;15(6):910-4
PMID 11417476
 
High incidence of CALM-AF10 fusion and the identification of a novel fusion transcript in acute megakaryoblastic leukemia in children without Down's syndrome
Abdelhaleem M, Beimnet K, Kirby-Allen M, Naqvi A, Hitzler J, Shago M
Leukemia 2007 Feb;21(2):352-3
PMID 17170719
 
Incidence of MLL rearrangement in acute myeloid leukemia, and a CALM-AF10 fusion in M4 type acute myeloblastic leukemia
Abdou SM, Jadayel DM, Min T, Swansbury GJ, Dainton MG, Jafer O, Powles RL, Catovsky D
Leuk Lymphoma 2002 Jan;43(1):89-95
PMID 11911106
 
Monocytic leukemia with CALM/AF10 rearrangement showing mediastinal emphysema
Nakamura F, Maki K, Arai Y, Nakamura Y, Mitani K
Am J Hematol 2003 Feb;72(2):138-42
PMID 12555219
 
Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9
Sindt A, Deau B, Brahim W, Staal A, Visanica S, Villarese P, Rault JP, Macintyre E, Delabesse E
Genes Chromosomes Cancer 2006 Jun;45(6):575-82
PMID 16518848
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(10;11)(p12;q14)|t(10;11)(p12;q23) PICALM/MLLT10

External links

PICALM () MLLT10 (10p12.31)

Mitelman databaset(10;11)(p12;q14)|t(10;11)(p12;q23) [Case List]    t(10;11)(p12;q14)|t(10;11)(p12;q23) [Transloc-MCList] PICALM/MLLT10 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 9 10:15:11 CEST 2018


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jlhuret@AtlasGeneticsOncology.org.