t(10;12)(p12;q21) NAP1L1/MLLT10

Identity

ICD-Topo	C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id	2995
Note	Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene Name	NAP1L1
Location	12q21.2

Gene Name	MLLT10
Location	10p12.31

Bibliography

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG

Nature 2012 Jan 11;481(7380):157-63

PMID 22237106

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, McCastlain K, Edmonson M, Pounds SB, Shi L, Zhou X, Ma X, Sioson E, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Auvil JG, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino BP, Downing JR, Loh ML, Hunger SP, Zhang J, Mullighan CG

Nat Genet 2017 Aug;49(8):1211-1218

PMID 28671688

Translocations implicated (Data extracted from papers in the Atlas)

	t(10;12)(p12;q21) NAP1L1/MLLT10

External links

NAP1L1 (12q21.2) MLLT10 (10p12.31)

Mitelman database	t(10;12)(p12;q21) [Case List]    t(10;12)(p12;q21) [Transloc-MCList] NAP1L1/MLLT10 [Fusion-MCList]
COSMIC	Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)	[select an item]

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
All articles	automatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Nov 28 16:22:56 CET 2018

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