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t(10;14)(q24;q11) TRA/TLX1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3283

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameTRA
Location 10q26.13
Gene NameTLX1
Location 10q24.31

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases
Schneider NR, Carroll AJ, Shuster JJ, Pullen DJ, Link MP, Borowitz MJ, Camitta BM, Katz JA, Amylon MD
Blood 2000 Oct 1;96(7):2543-9
PMID 11001909
 
Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951
Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N; EORTC-CLG
Blood 2004 Jan 15;103(2):442-50
PMID 14504110
 
Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
Moorman AV, Harrison CJ, Buck GA, Richards SM, Secker-Walker LM, Martineau M, Vance GH, Cherry AM, Higgins RR, Fielding AK, Foroni L, Paietta E, Tallman MS, Litzow MR, Wiernik PH, Rowe JM, Goldstone AH, Dewald GW; Adult Leukaemia Working Party, Medical Research Council/National Cancer Research Institute
Blood 2007 Apr 15;109(8):3189-97
PMID 17170120
 
Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: rare T-cell receptor gene rearrangements are associated with poor outcome
Karrman K, Forestier E, Heyman M, Andersen MK, Autio K, Blennow E, Borgström G, Ehrencrona H, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Palmqvist L, Johansson B; Nordic Society of Pediatric Hematology, Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG)
Genes Chromosomes Cancer 2009 Sep;48(9):795-805
PMID 19530250
 
The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24
Zutter M, Hockett RD, Roberts CW, McGuire EA, Bloomstone J, Morton CC, Deaven LL, Crist WM, Carroll AJ, Korsmeyer SJ
Proc Natl Acad Sci U S A 1990 Apr;87(8):3161-5
PMID 2326274
 
Detection of minimal residual disease in leukemic patients with the t(10;14)(q24;q11) chromosomal translocation
Kagan J, Finger LR, Besa E, Croce CM
Cancer Res 1990 Sep 1;50(17):5240-4
PMID 2386934
 
Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia
Atak ZK, Gianfelici V, Hulselmans G, De Keersmaecker K, Devasia AG, Geerdens E, Mentens N, Chiaretti S, Durinck K, Uyttebroeck A, Vandenberghe P, Wlodarska I, Cloos J, Foà R, Speleman F, Cools J, Aerts S
PLoS Genet 2013;9(12):e1003997
PMID 24367274
 
Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation
Kagan J, Finger LR, Letofsky J, Finan J, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1989 Jun;86(11):4161-5
PMID 2542965
 
Recurrent SPI1 (PU
Seki M, Kimura S, Isobe T, Yoshida K, Ueno H, Nakajima-Takagi Y, Wang C, Lin L, Kon A, Suzuki H, Shiozawa Y, Kataoka K, Fujii Y, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Masuda K, Kawamoto H, Ohki K, Kato M, Arakawa Y, Koh K, Hanada R, Moritake H, Akiyama M, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Oka A, Hayashi Y, Takagi M, Manabe A, Ohara A, Horibe K, Sanada M, Iwama A, Mano H, Miyano S, Ogawa S, Takita J
1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia Nat Genet
PMID 28671687
 
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, McCastlain K, Edmonson M, Pounds SB, Shi L, Zhou X, Ma X, Sioson E, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Auvil JG, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino BP, Downing JR, Loh ML, Hunger SP, Zhang J, Mullighan CG
Nat Genet 2017 Aug;49(8):1211-1218
PMID 28671688
 
Alpha-chain locus of the T-cell antigen receptor is involved in the t(10;14) chromosome translocation of T-cell acute lymphocytic leukemia
Kagan J, Finan J, Letofsky J, Besa EC, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1987 Jul;84(13):4543-6
PMID 2885838
 
A Collaborative Study of the Group Français de Cytogénétique Hématologique
Cytogenetic abnormalities in adult acute lymphoblastic leukemia: correlations with hematologic findings outcome
Blood 1996 Apr 15;87(8):3135-42
PMID 8605327
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(10;14)(q24;q11) TRA/TLX1

External links

TRA (10q26.13) TLX1 (10q24.31)

Mitelman databaset(10;14)(q24;q11) [Case List]    t(10;14)(q24;q11) [Transloc-MCList] TRA/TLX1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Fri Feb 23 20:24:42 CET 2018


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