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t(10;14)(q24;q11) TRD/TLX1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3467
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Mature T- and NK-cell neoplasm, NOS

Genes involved and Proteins

Gene NameTRD
Location 10p13
Gene NameTLX1
Location 10q24.31

Bibliography

Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951
Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N; EORTC-CLG
Blood 2004 Jan 15;103(2):442-50
PMID 14504110
 
The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24
Zutter M, Hockett RD, Roberts CW, McGuire EA, Bloomstone J, Morton CC, Deaven LL, Crist WM, Carroll AJ, Korsmeyer SJ
Proc Natl Acad Sci U S A 1990 Apr;87(8):3161-5
PMID 2326274
 
Detection of minimal residual disease in leukemic patients with the t(10;14)(q24;q11) chromosomal translocation
Kagan J, Finger LR, Besa E, Croce CM
Cancer Res 1990 Sep 1;50(17):5240-4
PMID 2386934
 
Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation
Kagan J, Finger LR, Letofsky J, Finan J, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1989 Jun;86(11):4161-5
PMID 2542965
 
Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation
Kagan J, Finger LR, Letofsky J, Finan J, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1989 Jun;86(11):4161-5
PMID 2542965
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(10;14)(q24;q11) TRD/TLX1

External links

TRD (10p13) TLX1 (10q24.31)

Mitelman databaset(10;14)(q24;q11) [Case List]    t(10;14)(q24;q11) [Transloc-MCList] TRD/TLX1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Jul 9 10:15:14 CEST 2018


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