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t(11;11)(q23;q23) KMT2A/BCL9L

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2867

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameBCL9L
Location 11q23.3

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements
Pui CH, Chessells JM, Camitta B, Baruchel A, Biondi A, Boyett JM, Carroll A, Eden OB, Evans WE, Gadner H, Harbott J, Harms DO, Harrison CJ, Harrison PL, Heerema N, Janka-Schaub G, Kamps W, Masera G, Pullen J, Raimondi SC, Richards S, Riehm H, Sallan S, Sather H, Shuster J, Silverman LB, Valsecchi MG, Vilmer E, Zhou Y, Gaynon PS, Schrappe M
Leukemia 2003 Apr;17(4):700-6
PMID 12682627
 
No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities
Moorman AV, Raimondi SC, Pui CH, Baruchel A, Biondi A, Carroll AJ, Forestier E, Gaynon PS, Harbott J, Harms DO, Heerema N, Pieters R, Schrappe M, Silverman LB, Vilmer E, Harrison CJ; Ponte di Legno Working Group
Leukemia 2005 Apr;19(4):557-63
PMID 15744345
 
The MLL recombinome of acute leukemias
Meyer C, Schneider B, Jakob S, Strehl S, Attarbaschi A, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, den Boer ML, Pieters R, Ennas MG, Angelucci E, Koehl U, Greil J, Griesinger F, Zur Stadt U, Eckert C, Szczepański T, Niggli FK, Schäfer BW, Kempski H, Brady HJ, Zuna J, Trka J, Nigro LL, Biondi A, Delabesse E, Macintyre E, Stanulla M, Schrappe M, Haas OA, Burmeister T, Dingermann T, Klingebiel T, Marschalek R
Leukemia 2006 May;20(5):777-84
PMID 16511515
 
Pediatric T-cell acute lymphoblastic leukemia with aberrations of both MLL loci
Quigley DI, Wolff DJ
Cancer Genet Cytogenet 2006 Jul 1;168(1):77-9
PMID 16772125
 
Deletion of 11q23 is a highly specific nonrandom secondary genetic abnormality of ETV6/RUNX1-rearranged childhood acute lymphoblastic leukemia
Attarbaschi A, Mann G, Strehl S, König M, Steiner M, Jeitler V, Lion T, Dworzak MN, Gadner H, Haas OA
Leukemia 2007 Mar;21(3):584-6
PMID 17215856
 
The MLL recombinome of acute leukemias in 2013
Meyer C, Hofmann J, Burmeister T, Gröger D, Park TS, Emerenciano M, Pombo de Oliveira M, Renneville A, Villarese P, Macintyre E, Cavé H, Clappier E, Mass-Malo K, Zuna J, Trka J, De Braekeleer E, De Braekeleer M, Oh SH, Tsaur G, Fechina L, van der Velden VH, van Dongen JJ, Delabesse E, Binato R, Silva ML, Kustanovich A, Aleinikova O, Harris MH, Lund-Aho T, Juvonen V, Heidenreich O, Vormoor J, Choi WW, Jarosova M, Kolenova A, Bueno C, Menendez P, Wehner S, Eckert C, Talmant P, Tondeur S, Lippert E, Launay E, Henry C, Ballerini P, Lapillone H, Callanan MB, Cayuela JM, Herbaux C, Cazzaniga G, Kakadiya PM, Bohlander S, Ahlmann M, Choi JR, Gameiro P, Lee DS, Krauter J, Cornillet-Lefebvre P, Te Kronnie G, Schäfer BW, Kubetzko S, Alonso CN, zur Stadt U, Sutton R, Venn NC, Izraeli S, Trakhtenbrot L, Madsen HO, Archer P, Hancock J, Cerveira N, Teixeira MR, Lo Nigro L, Möricke A, Stanulla M, Schrappe M, Sedék L, Szczepański T, Zwaan CM, Coenen EA, van den Heuvel-Eibrink MM, Strehl S, Dworzak M, Panzer-Grümayer R, Dingermann T, Klingebiel T, Marschalek R
Leukemia 2013 Nov;27(11):2165-76
PMID 23628958
 
ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children
Felix CA, Hosler MR, Winick NJ, Masterson M, Wilson AE, Lange BJ
Blood 1995 Jun 1;85(11):3250-6
PMID 7756657
 
HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities
Hunger SP, Tkachuk DC, Amylon MD, Link MP, Carroll AJ, Welborn JL, Willman CL, Cleary ML
Blood 1993 Jun 15;81(12):3197-203
 
Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia
Taki T, Ida K, Bessho F, Hanada R, Kikuchi A, Yamamoto K, Sako M, Tsuchida M, Seto M, Ueda R, Hayashi Y
Leukemia 1996 Aug;10(8):1303-7
PMID 8709635
 
Hematological malignancies with a deletion of 11q23: cytogenetic and clinical aspects
Harbott J, Mancini M, Verellen-Dumoulin C, Moorman AV, Secker-Walker LM
European 11q23 Workshop participants Leukemia
PMID 9593287
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;11)(q23;q23) KMT2A/BCL9L

External links

KMT2A (11q23.3) BCL9L (11q23.3)

Mitelman databaset(11;11)(q23;q23) [Case List]    t(11;11)(q23;q23) [Transloc-MCList] KMT2A/BCL9L [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:22:32 CET 2018


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jlhuret@AtlasGeneticsOncology.org.