Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(11;12)(p15;q13) NUP98/HOXC13

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Atlas_Id 1363
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute myeloblastic leukemia with maturation (FAB type M2)|Acute myelomonocytic leukemia (FAB type M4)

Genes involved and Proteins

Gene NameNUP98
Location 11p15.4
Gene NameHOXC13
Location 12q13.13


Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13)
Panagopoulos I, Isaksson M, Billström R, Strömbeck B, Mitelman F, Johansson B
Genes Chromosomes Cancer 2003 Jan;36(1):107-12
PMID 12461755
Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)
La Starza R, Trubia M, Crescenzi B, Matteucci C, Negrini M, Martelli MF, Pelicci PG, Mecucci C
Genes Chromosomes Cancer 2003 Apr;36(4):420-3
PMID 12619167
Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review
Tosić N, Stojiljković M, Colović N, Colović M, Pavlović S
Cancer Genet Cytogenet 2009 Sep;193(2):98-103
PMID 19665070

Other genes implicated (Data extracted from papers in the Atlas) [ 1 ]

Genes HOXC13

Translocations implicated (Data extracted from papers in the Atlas)

 t(11;12)(p15;q13) NUP98/HOXC13

External links

NUP98 (11p15.4) HOXC13 (12q13.13)

Mitelman databaset(11;12)(p15;q13)
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
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indexed on : Mon Sep 7 15:10:05 CEST 2020

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