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t(11;12)(p15;q13) NUP98/HOXC11

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3038

Clinics and Pathology

Disease Acute monoblastic leukemia with differentiation (FAB type M5b):Acute myeloblastic leukemia with maturation (FAB type M2):Acute myeloblastic leukemia without maturation (FAB type M1)

Genes involved and Proteins

Gene NameNUP98
Location 11p15.4
Gene NameHOXC11
Location 12q13.13

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Novel NUP98-HOXC11 fusion gene resulted from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13)
Taketani T, Taki T, Shibuya N, Kikuchi A, Hanada R, Hayashi Y
Cancer Res 2002 Aug 15;62(16):4571-4
PMID 12183408
 
Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13)
Panagopoulos I, Isaksson M, Billström R, Strömbeck B, Mitelman F, Johansson B
Genes Chromosomes Cancer 2003 Jan;36(1):107-12
PMID 12461755
 
Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)
La Starza R, Trubia M, Crescenzi B, Matteucci C, Negrini M, Martelli MF, Pelicci PG, Mecucci C
Genes Chromosomes Cancer 2003 Apr;36(4):420-3
PMID 12619167
 
Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity
Gu BW, Wang Q, Wang JM, Xue YQ, Fang J, Wong KF, Chen B, Shi ZZ, Shi JY, Bai XT, Wu DH, Chen Z, Chen SJ
Leukemia 2003 Sep;17(9):1858-64
PMID 12970787
 
Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity
Gu BW, Wang Q, Wang JM, Xue YQ, Fang J, Wong KF, Chen B, Shi ZZ, Shi JY, Bai XT, Wu DH, Chen Z, Chen SJ
Leukemia 2003 Sep;17(9):1858-64
PMID 12970787
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;12)(p15;q13) NUP98/HOXC11

External links

NUP98 (11p15.4) HOXC11 (12q13.13)

Mitelman databaset(11;12)(p15;q13) [Case List]    t(11;12)(p15;q13) [Transloc-MCList] NUP98/HOXC11 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Fri Feb 23 20:24:51 CET 2018


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