Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(11;12)(p15;q13) NUP98/HOXC13

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3039

Clinics and Pathology

Disease Acute myeloblastic leukemia with maturation (FAB type M2):Acute myelomonocytic leukemia (FAB type M4)

Genes involved and Proteins

Gene NameNUP98
Location 11p15.4
Gene NameHOXC13
Location 12q13.13

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13)
Panagopoulos I, Isaksson M, Billström R, Strömbeck B, Mitelman F, Johansson B
Genes Chromosomes Cancer 2003 Jan;36(1):107-12
PMID 12461755
 
Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)
La Starza R, Trubia M, Crescenzi B, Matteucci C, Negrini M, Martelli MF, Pelicci PG, Mecucci C
Genes Chromosomes Cancer 2003 Apr;36(4):420-3
PMID 12619167
 
Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity
Gu BW, Wang Q, Wang JM, Xue YQ, Fang J, Wong KF, Chen B, Shi ZZ, Shi JY, Bai XT, Wu DH, Chen Z, Chen SJ
Leukemia 2003 Sep;17(9):1858-64
PMID 12970787
 
Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review
Tosić N, Stojiljković M, Colović N, Colović M, Pavlović S
Cancer Genet Cytogenet 2009 Sep;193(2):98-103
PMID 19665070
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;12)(p15;q13) NUP98/HOXC13

External links

NUP98 (11p15.4) HOXC13 (12q13.13)

Mitelman databaset(11;12)(p15;q13) [Case List]    t(11;12)(p15;q13) [Transloc-MCList] NUP98/HOXC13 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jan 10 17:22:35 CET 2018


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.