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t(11;14)(p13;q11) TRA/LMO2

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3277

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameTRA
Location 10q26.13
Gene NameLMO2
Location 11p13

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases
Schneider NR, Carroll AJ, Shuster JJ, Pullen DJ, Link MP, Borowitz MJ, Camitta BM, Katz JA, Amylon MD
Blood 2000 Oct 1;96(7):2543-9
PMID 11001909
TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)
Royer-Pokora B, Loos U, Ludwig WD
Oncogene 1991 Oct;6(10):1887-93
PMID 1923511
Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: rare T-cell receptor gene rearrangements are associated with poor outcome
Karrman K, Forestier E, Heyman M, Andersen MK, Autio K, Blennow E, Borgström G, Ehrencrona H, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Palmqvist L, Johansson B; Nordic Society of Pediatric Hematology, Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG)
Genes Chromosomes Cancer 2009 Sep;48(9):795-805
PMID 19530250
The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13
Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH
Proc Natl Acad Sci U S A 1991 May 15;88(10):4367-71
PMID 2034676
Clinical and biologic features of childhood T-cell leukemia with the t(11;14)
Ribeiro RC, Raimondi SC, Behm FG, Cherrie J, Crist WM, Pui CH
Blood 1991 Jul 15;78(2):466-70
PMID 2070082
Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2 by juxtaposition with MBNL1 and STAG2
Chen S, Nagel S, Schneider B, Kaufmann M, Meyer C, Zaborski M, Kees UR, Drexler HG, MacLeod RA
Leukemia 2011 Oct;25(10):1632-5
PMID 21647158
Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL
Le Noir S, Ben Abdelali R, Lelorch M, Bergeron J, Sungalee S, Payet-Bornet D, Villarèse P, Petit A, Callens C, Lhermitte L, Baranger L, Radford-Weiss I, Grégoire MJ, Dombret H, Ifrah N, Spicuglia S, Romana S, Soulier J, Nadel B, Macintyre E, Asnafi V
Blood 2012 Oct 18;120(16):3298-309
PMID 22948044
Translocations and rearrangements in T-cell acute leukemias with the t(11;14) (p13;q11) chromosomal translocations
Harvey RC, Martinerie C, Sun LH, Williams D, Showe LC
Oncogene 1989 Mar;4(3):341-9
PMID 2523031
The T-cell receptor delta chain locus is disrupted in the T-ALL associated t(11;14)(p13;q11) translocation
Champagne E, Takihara Y, Sagman U, de Sousa J, Burrow S, Lewis WH, Mak TW, Minden MD
Blood 1989 May 1;73(6):1672-6
PMID 2523742
The chromosome translocation (11;14)(p13;q11) associated with T-cell acute lymphocytic leukemia: an 11p13 breakpoint cluster region
Yoffe G, Schneider N, Van Dyk L, Yang CY, Siciliano M, Buchanan G, Capra JD, Baer R
Blood 1989 Jul;74(1):374-9
PMID 2526665
Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours
Boehm T, Mengle-Gaw L, Kees UR, Spurr N, Lavenir I, Forster A, Rabbitts TH
EMBO J 1989 Sep;8(9):2621-31
PMID 2531086
The chromosome 11 region flanking the t(11;14) breakpoint in human T-ALL is deleted in Wilms' tumor hybrids
Finver SN, Martiniere C, Kagan J, Cavenee W, Croce CM
Oncogene Res 1989;5(2):143-8
PMID 2558334
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, McCastlain K, Edmonson M, Pounds SB, Shi L, Zhou X, Ma X, Sioson E, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Auvil JG, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino BP, Downing JR, Loh ML, Hunger SP, Zhang J, Mullighan CG
Nat Genet 2017 Aug;49(8):1211-1218
PMID 28671688
Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia
Pui CH, Williams DL, Roberson PK, Raimondi SC, Behm FG, Lewis SH, Rivera GK, Kalwinsky DK, Abromowitch M, Crist WM, et al
J Clin Oncol 1988 Jan;6(1):56-61
PMID 2961852
A cluster of chromosome 11p13 translocations found via distinct D-D and D-D-J rearrangements of the human T cell receptor delta chain gene
Boehm T, Buluwela L, Williams D, White L, Rabbitts TH
EMBO J 1988 Jul;7(7):2011-7
PMID 3416831
Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukemia
Williams DL, Harber J, Murphy SB, Look AT, Kalwinsky DK, Rivera G, Melvin SL, Stass S, Dahl GV
Blood 1986 Jul;68(1):205-12
PMID 3459555
T-cell acute lymphoblastic leukemias with a t(8;14) possibly involving a c-myc locus and T-cell-receptor alpha-chain genes
Hayashi Y, Yamamoto K, Kojima S
N Engl J Med 1986 Mar 6;314(10):650-1
PMID 3484803
Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias
Erikson J, Williams DL, Finan J, Nowell PC, Croce CM
Science 1985 Aug 23;229(4715):784-6
PMID 3875152
Breakpoints in the human T-cell antigen receptor alpha-chain locus in two T-cell leukaemia patients with chromosomal translocations
Lewis WH, Michalopoulos EE, Williams DL, Minden MD, Mak TW
Nature 1985 Oct 10-16;317(6037):544-6
PMID 3876514
New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia
Williams DL, Look AT, Melvin SL, Roberson PK, Dahl G, Flake T, Stass S
Cell 1984 Jan;36(1):101-9
PMID 6607116

Translocations implicated (Data extracted from papers in the Atlas)

 t(11;14)(p13;q11) TRA/LMO2

External links

TRA (10q26.13) LMO2 (11p13)

Mitelman databaset(11;14)(p13;q11) [Case List]    t(11;14)(p13;q11) [Transloc-MCList] TRA/LMO2 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Fri Feb 23 20:24:53 CET 2018

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