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t(11;14)(p15;q11) LMO1/TRA

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2927

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameLMO1
Location 11p15.4
Gene NameTRA
Location 10q26.13

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells
McGuire EA, Davis AR, Korsmeyer SJ
Blood 1991 Feb 1;77(3):599-606
PMID 1703797
 
The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein
McGuire EA, Hockett RD, Pollock KM, Bartholdi MF, O'Brien SJ, Korsmeyer SJ
Mol Cell Biol 1989 May;9(5):2124-32
PMID 2501659
 
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, McCastlain K, Edmonson M, Pounds SB, Shi L, Zhou X, Ma X, Sioson E, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Auvil JG, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino BP, Downing JR, Loh ML, Hunger SP, Zhang J, Mullighan CG
Nat Genet 2017 Aug;49(8):1211-1218
PMID 28671688
 
The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15
Boehm T, Baer R, Lavenir I, Forster A, Waters JJ, Nacheva E, Rabbitts TH
EMBO J 1988 Feb;7(2):385-94
PMID 3259177
 
T-cell receptor alpha-chain gene is split in a human T-cell leukemia cell line with a t(11;14)(p15;q11)
Le Beau MM, McKeithan TW, Shima EA, Goldman-Leikin RE, Chan SJ, Bell GI, Rowley JD, Diaz MO
Proc Natl Acad Sci U S A 1986 Dec;83(24):9744-8
PMID 3540949
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;14)(p15;q11) LMO1/TRA

External links

LMO1 (11p15.4) TRA (10q26.13)

Mitelman databaset(11;14)(p15;q11) [Case List]    t(11;14)(p15;q11) [Transloc-MCList] LMO1/TRA [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:22:36 CET 2018


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