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t(11;14)(q23;q23) KMT2A/GPHN

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3474
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute monoblastic leukemia (FAB type M5)|Acute undifferentiated leukemia

Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameGPHN

Bibliography

t(11;14)(q23;q24) generates an MLL-human gephyrin fusion gene along with a de facto truncated MLL in acute monoblastic leukemia
Kuwada N, Kimura F, Matsumura T, Yamashita T, Nakamura Y, Wakimoto N, Ikeda T, Sato K, Motoyoshi K
Cancer Res 2001 Mar 15;61(6):2665-9
PMID 11289145
 
GPHN, a novel partner gene fused to MLL in a leukemia with t(11;14)(q23;q24)
Eguchi M, Eguchi-Ishimae M, Seto M, Morishita K, Suzuki K, Ueda R, Ueda K, Kamada N, Greaves M
Genes Chromosomes Cancer 2001 Nov;32(3):212-21
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;14)(q23;q23) KMT2A/GPHN

External links

KMT2A (11q23.3) GPHN ()

Mitelman databaset(11;14)(q23;q23) [Case List]    t(11;14)(q23;q23) [Transloc-MCList] KMT2A/GPHN [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Jul 9 10:15:28 CEST 2018


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