Identity |
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
Atlas_Id | 2900 |
Note | Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to How to contribute |
Clinics and Pathology |
Disease | Refractory anemia with ringed sideroblasts |
Genes involved and Proteins |
Gene Name | KMT2A |
Location | 11q23.3 |
Gene Name | TCF12 |
Location | 15q21.3 |
Bibliography |
A complex MLL rearrangement identified five years after initial MDS diagnosis results in out-of-frame fusions without progression to acute leukemia |
Meyer C, Kowarz E, Yip SF, Wan TS, Chan TK, Dingermann T, Chan LC, Marschalek R |
Cancer Genet 2011 Oct;204(10):557-62 |
PMID 22137486 |
Translocations implicated (Data extracted from papers in the Atlas) |
t(11;15)(q23;q21) KMT2A/TCF12 | |
External links |
Mitelman database | t(11;15)(q23;q21) |
COSMIC | Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC) |
arrayMap (UZH-SIB Zurich) | [select an item] |
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:28:42 CET 2020 |
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