| Written | 2018-01 | Jean-Loup Huret, Philippe Dessen |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| Atlas_Id | 2900 |
| Note | Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to How to contribute |
| Clinics and Pathology |
| Disease | Refractory anemia with ringed sideroblasts |
| Genes involved and Proteins |
| Gene Name | KMT2A |
| Location | 11q23.3 |
| Gene Name | TCF12 |
| Location | 15q21.3 |
| Bibliography |
| A complex MLL rearrangement identified five years after initial MDS diagnosis results in out-of-frame fusions without progression to acute leukemia |
| Meyer C, Kowarz E, Yip SF, Wan TS, Chan TK, Dingermann T, Chan LC, Marschalek R |
| Cancer Genet 2011 Oct;204(10):557-62 |
| PMID 22137486 |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(11;15)(q23;q21) KMT2A/TCF12 | |
| External links |
| Mitelman database | t(11;15)(q23;q21) |
| COSMIC | Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC) |
| arrayMap (UZH-SIB Zurich) | [select an item] |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sun Jul 12 19:48:38 CEST 2020 |
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