t(11;15)(q23;q21) KMT2A/TCF12

Identity

ICD-Topo	C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id	2900
Note	Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease

Refractory anemia with ringed sideroblasts

Genes involved and Proteins

Gene Name	KMT2A
Location	11q23.3

Gene Name	TCF12
Location	15q21.3

Bibliography

A complex MLL rearrangement identified five years after initial MDS diagnosis results in out-of-frame fusions without progression to acute leukemia

Meyer C, Kowarz E, Yip SF, Wan TS, Chan TK, Dingermann T, Chan LC, Marschalek R

Cancer Genet 2011 Oct;204(10):557-62

PMID 22137486

Translocations implicated (Data extracted from papers in the Atlas)

	t(11;15)(q23;q21) KMT2A/TCF12

External links

KMT2A (11q23.3) TCF12 (15q21.3)

Mitelman database	t(11;15)(q23;q21) [Case List]    t(11;15)(q23;q21) [Transloc-MCList] KMT2A/TCF12 [Fusion-MCList]
COSMIC	Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)	[select an item]

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
All articles	automatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Tue Aug 28 18:21:50 CEST 2018

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