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t(11;16)(q23;p13) KMT2A/CREBBP

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3477
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Acute monoblastic leukemia without differentiation (FAB type M5a)|Acute myeloblastic leukemia with maturation (FAB type M2)|Acute myeloid leukemia, NOS|Acute myelomonocytic leukemia (FAB type M4)|Chronic myelomonocytic leukemia|Myelodysplastic syndrome, NOS

Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameCREBBP
Location 16p13.3

Bibliography

MLL-CBP fusion transcript in a therapy-related acute myeloid leukemia with the t(11;16)(q23;p13) which developed in an acute lymphoblastic leukemia patient with Fanconi anemia
Sugita K, Taki T, Hayashi Y, Shimaoka H, Kumazaki H, Inoue H, Konno Y, Taniwaki M, Kurosawa H, Eguchi M
Genes Chromosomes Cancer 2000 Mar;27(3):264-9
PMID 10679915
 
The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene
Taki T, Sako M, Tsuchida M, Hayashi Y
Blood 1997 Jun 1;89(11):3945-50
PMID 9166831
 
MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13
Sobulo OM, Borrow J, Tomek R, Reshmi S, Harden A, Schlegelberger B, Housman D, Doggett NA, Rowley JD, Zeleznik-Le NJ
3) Proc Natl Acad Sci U S A
PMID 9238046
 
The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene
Taki T, Sako M, Tsuchida M, Hayashi Y
Blood 1997 Jun 1;89(11):3945-50
PMID 9166831
 
All patients with the T(11;16)(q23;p13
Rowley JD, Reshmi S, Sobulo O, Musvee T, Anastasi J, Raimondi S, Schneider NR, Barredo JC, Cantu ES, Schlegelberger B, Behm F, Doggett NA, Borrow J, Zeleznik-Le N
3) that involves MLL and CBP have treatment-related hematologic disorders Blood
PMID 9226152
 
All patients with the T(11;16)(q23;p13
Rowley JD, Reshmi S, Sobulo O, Musvee T, Anastasi J, Raimondi S, Schneider NR, Barredo JC, Cantu ES, Schlegelberger B, Behm F, Doggett NA, Borrow J, Zeleznik-Le N
3) that involves MLL and CBP have treatment-related hematologic disorders Blood
PMID 9226152
 
All patients with the T(11;16)(q23;p13
Rowley JD, Reshmi S, Sobulo O, Musvee T, Anastasi J, Raimondi S, Schneider NR, Barredo JC, Cantu ES, Schlegelberger B, Behm F, Doggett NA, Borrow J, Zeleznik-Le N
3) that involves MLL and CBP have treatment-related hematologic disorders Blood
PMID 9226152
 
Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16)(q23;p13) chromosome translocation
Satake N, Ishida Y, Otoh Y, Hinohara S, Kobayashi H, Sakashita A, Maseki N, Kaneko Y
Genes Chromosomes Cancer 1997 Sep;20(1):60-3
PMID 9290955
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;16)(q23;p13) KMT2A/CREBBP

External links

KMT2A (11q23.3) CREBBP (16p13.3)

Mitelman databaset(11;16)(q23;p13) [Case List]    t(11;16)(q23;p13) [Transloc-MCList] KMT2A/CREBBP [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Jul 9 10:15:31 CEST 2018


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