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t(11;19)(q23;p13) KMT2A/SUGP2

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2899

Clinics and Pathology

Disease Acute monoblastic leukemia with differentiation (FAB type M5b)

Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameSUGP2
Location 19p13

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

A dual-color FISH assay distinguishes between ELL and MLLT1 (ENL) gene rearrangements in t(11;19)-positive acute leukemia
Biggerstaff JS, Liu W, Slovak ML, Bobadilla D, Bryant E, Glotzbach C, Shaffer LG
Leukemia 2006 Nov;20(11):2046-50
PMID 16990786
 
Targeted next-generation sequencing detects point mutations, insertions, deletions and balanced chromosomal rearrangements as well as identifies novel leukemia-specific fusion genes in a single procedure
Grossmann V, Kohlmann A, Klein HU, Schindela S, Schnittger S, Dicker F, Dugas M, Kern W, Haferlach T, Haferlach C
Leukemia 2011 Apr;25(4):671-80
PMID 21252984
 
Identification of MLL partner genes in 27 patients with acute leukemia from a single cytogenetic laboratory
De Braekeleer E, Meyer C, Douet-Guilbert N, Basinko A, Le Bris MJ, Morel F, Berthou C, Marschalek R, Férec C, De Braekeleer M
Mol Oncol 2011 Dec;5(6):555-63
PMID 21900057
 
A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities
Yamamoto K, Seto M, Iida S, Komatsu H, Kamada N, Kojima S, Kodera Y, Nakazawa S, Saito H, Takahashi T, et al
Blood 1994 May 15;83(10):2912-21
PMID 8180386
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;19)(q23;p13) KMT2A/SUGP2

External links

KMT2A (11q23.3) SUGP2 (19p13)

Mitelman databaset(11;19)(q23;p13) [Case List]    t(11;19)(q23;p13) [Transloc-MCList] KMT2A/SUGP2 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:22:42 CET 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.