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t(11;19)(q23;p13) KMT2A/ELL

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3479
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Acute monoblastic leukemia with differentiation (FAB type M5b)|Acute myeloblastic leukemia with maturation (FAB type M2)|Acute myeloid leukemia, NOS|Acute myelomonocytic leukemia (FAB type M4)|Bilineage or biphenotypic leukemia|Chronic myelomonocytic leukemia|Chronic myeloproliferative disorder, NOS|Myelodysplastic syndrome, NOS|Refractory anemia with excess of blasts (FAB)

Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameELL
Location 19p13.11

Bibliography

Multiplex reverse transcriptase-polymerase chain reaction screening in childhood acute myeloblastic leukemia
Strehl S, König M, Mann G, Haas OA
Blood 2001 Feb 1;97(3):805-8
PMID 11157501
 
The translocations, t(11;19)(q23;p13
Moorman AV, Hagemeijer A, Charrin C, Rieder H, Secker-Walker LM
1) and t(11;19)(q23;p13 3): a cytogenetic and clinical profile of 53 patients
PMID 9593285
 
Translocation (8;12)(q13;p13) during disease progression in acute myelomonocytic leukemia with t(11;19)(q23;p13
Yamamoto K, Nagata K, Tsurukubo Y, Inagaki K, Ono R, Taki T, Hayashi Y, Hamaguchi H
1) Cancer Genet Cytogenet
PMID 12377416
 
Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13
Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD
1) in acute myeloid leukemia Proc Natl Acad Sci U S A
PMID 7991593
 
A dual-color FISH assay distinguishes between ELL and MLLT1 (ENL) gene rearrangements in t(11;19)-positive acute leukemia
Biggerstaff JS, Liu W, Slovak ML, Bobadilla D, Bryant E, Glotzbach C, Shaffer LG
Leukemia 2006 Nov;20(11):2046-50
PMID 16990786
 
A dual-color FISH assay distinguishes between ELL and MLLT1 (ENL) gene rearrangements in t(11;19)-positive acute leukemia
Biggerstaff JS, Liu W, Slovak ML, Bobadilla D, Bryant E, Glotzbach C, Shaffer LG
Leukemia 2006 Nov;20(11):2046-50
PMID 16990786
 
Identification of MLL partner genes in 27 patients with acute leukemia from a single cytogenetic laboratory
De Braekeleer E, Meyer C, Douet-Guilbert N, Basinko A, Le Bris MJ, Morel F, Berthou C, Marschalek R, Férec C, De Braekeleer M
Mol Oncol 2011 Dec;5(6):555-63
PMID 21900057
 
A novel variant form of MLL-ELL fusion transcript with t(11;19)(q23;p13
Kakihana K, Kubo F, Wakabayashi S, Kurosu T, Miki T, Murakami N, Miura O
1) in chronic myelomonocytic leukemia transforming to acute myeloid leukemia Cancer Genet Cytogenet
PMID 18617060
 
Involvement of the MLL gene in adult T-lymphoblastic leukemia
Türkmen S, Timmermann B, Bartels G, Gröger D, Meyer C, Schwartz S, Haferlach C, Rieder H, Gökbuget N, Hoelzer D, Marschalek R, Burmeister T
Genes Chromosomes Cancer 2012 Dec;51(12):1114-24
PMID 22927255
 
The MLL recombinome of acute leukemias in 2013
Meyer C, Hofmann J, Burmeister T, Gröger D, Park TS, Emerenciano M, Pombo de Oliveira M, Renneville A, Villarese P, Macintyre E, Cavé H, Clappier E, Mass-Malo K, Zuna J, Trka J, De Braekeleer E, De Braekeleer M, Oh SH, Tsaur G, Fechina L, van der Velden VH, van Dongen JJ, Delabesse E, Binato R, Silva ML, Kustanovich A, Aleinikova O, Harris MH, Lund-Aho T, Juvonen V, Heidenreich O, Vormoor J, Choi WW, Jarosova M, Kolenova A, Bueno C, Menendez P, Wehner S, Eckert C, Talmant P, Tondeur S, Lippert E, Launay E, Henry C, Ballerini P, Lapillone H, Callanan MB, Cayuela JM, Herbaux C, Cazzaniga G, Kakadiya PM, Bohlander S, Ahlmann M, Choi JR, Gameiro P, Lee DS, Krauter J, Cornillet-Lefebvre P, Te Kronnie G, Schäfer BW, Kubetzko S, Alonso CN, zur Stadt U, Sutton R, Venn NC, Izraeli S, Trakhtenbrot L, Madsen HO, Archer P, Hancock J, Cerveira N, Teixeira MR, Lo Nigro L, Möricke A, Stanulla M, Schrappe M, Sedék L, Szczepański T, Zwaan CM, Coenen EA, van den Heuvel-Eibrink MM, Strehl S, Dworzak M, Panzer-Grümayer R, Dingermann T, Klingebiel T, Marschalek R
Leukemia 2013 Nov;27(11):2165-76
PMID 23628958
 
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, McCastlain K, Edmonson M, Pounds SB, Shi L, Zhou X, Ma X, Sioson E, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Auvil JG, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino BP, Downing JR, Loh ML, Hunger SP, Zhang J, Mullighan CG
Nat Genet 2017 Aug;49(8):1211-1218
PMID 28671688
 
The landscape and therapeutic relevance of cancer-associated transcript fusions
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG
Oncogene 2015 Sep 10;34(37):4845-54
PMID 25500544
 
Cloning of several species of MLL/MEN chimeric cDNAs in myeloid leukemia with t(11;19)(q23;p13
Mitani K, Kanda Y, Ogawa S, Tanaka T, Inazawa J, Yazaki Y, Hirai H
1) translocation Blood
PMID 7718874
 
Subcellular localization of the MEN, MLL/MEN and truncated MLL proteins expressed in leukemic cells carrying the t(11;19)(q23;p13
Kanda Y, Mitani K, Tanaka T, Tanaka K, Ogawa S, Yazaki Y, Hirai H
1) translocation Int J Hematol
PMID 9277049
 
The translocations, t(11;19)(q23;p13
Moorman AV, Hagemeijer A, Charrin C, Rieder H, Secker-Walker LM
1) and t(11;19)(q23;p13 3): a cytogenetic and clinical profile of 53 patients
PMID 9593285
 
The translocations, t(11;19)(q23;p13
Moorman AV, Hagemeijer A, Charrin C, Rieder H, Secker-Walker LM
1) and t(11;19)(q23;p13 3): a cytogenetic and clinical profile of 53 patients
PMID 9593285
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;19)(q23;p13) KMT2A/ELL

External links

KMT2A (11q23.3) ELL (19p13.11)

Mitelman databaset(11;19)(q23;p13) [Case List]    t(11;19)(q23;p13) [Transloc-MCList] KMT2A/ELL [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Aug 28 18:21:56 CEST 2018


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jlhuret@AtlasGeneticsOncology.org.