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t(11;19)(q23;p13) KMT2A/MLLT1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3480
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Acute megakaryoblastic leukemia (FAB type M7)|Acute monoblastic leukemia (FAB type M5)|Acute monoblastic leukemia with differentiation (FAB type M5b)|Acute monoblastic leukemia without differentiation (FAB type M5a)|Acute myeloblastic leukemia with maturation (FAB type M2)|Acute myeloblastic leukemia with minimal differentiation (FAB type M0)|Acute myeloid leukemia, NOS|Acute myelomonocytic leukemia (FAB type M4)|Bilineage or biphenotypic leukemia|Dendritic cell neoplasm|Plasma cell neoplasm, special type

Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameMLLT1
Location 19p13.3

Bibliography

Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13
Rubnitz JE, Camitta BM, Mahmoud H, Raimondi SC, Carroll AJ, Borowitz MJ, Shuster JJ, Link MP, Pullen DJ, Downing JR, Behm FG, Pui CH
3) translocation J Clin Oncol
PMID 10458233
 
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
Tkachuk DC, Kohler S, Cleary ML
Cell 1992 Nov 13;71(4):691-700
PMID 1423624
 
A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities
Yamamoto K, Seto M, Iida S, Komatsu H, Kamada N, Kojima S, Kodera Y, Nakazawa S, Saito H, Takahashi T, et al
Blood 1994 May 15;83(10):2912-21
PMID 8180386
 
Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia
Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T, et al
Oncogene 1993 Oct;8(10):2617-25
PMID 8378076
 
Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation
Corral J, Forster A, Thompson S, Lampert F, Kaneko Y, Slater R, Kroes WG, van der Schoot CE, Ludwig WD, Karpas A, et al
Proc Natl Acad Sci U S A 1993 Sep 15;90(18):8538-42
PMID 8378328
 
Detection of chimeric mRNAs by reverse transcriptase-polymerase chain reaction for diagnosis and monitoring of acute leukemias with 11q23 abnormalities
Ida K, Taki T, Bessho F, Kobayashi M, Taira F, Hanada R, Yamamoto K, Okimoto Y, Seto M, Ueda R, Hayashi Y
Med Pediatr Oncol 1997 May;28(5):325-32
PMID 9121396
 
The translocations, t(11;19)(q23;p13
Moorman AV, Hagemeijer A, Charrin C, Rieder H, Secker-Walker LM
1) and t(11;19)(q23;p13 3): a cytogenetic and clinical profile of 53 patients
PMID 9593285
 
A DNA probe combination for improved detection of MLL/11q23 breakpoints by double-color interphase-FISH in acute leukemias
von Bergh A, Emanuel B, van Zelderen-Bhola S, Smetsers T, van Soest R, Stul M, Vranckx H, Schuuring E, Hagemeijer A, Kluin P
Genes Chromosomes Cancer 2000 May;28(1):14-22
PMID 10738298
 
Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement
Shih LY, Liang DC, Fu JF, Wu JH, Wang PN, Lin TL, Dunn P, Kuo MC, Tang TC, Lin TH, Lai CL
Leukemia 2006 Feb;20(2):218-23
PMID 16341046
 
Panhandle PCR for cDNA: a rapid method for isolation of MLL fusion transcripts involving unknown partner genes
Megonigal MD, Rappaport EF, Wilson RB, Jones DH, Whitlock JA, Ortega JA, Slater DJ, Nowell PC, Felix CA
Proc Natl Acad Sci U S A 2000 Aug 15;97(17):9597-602
PMID 10920186
 
Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia
Blanco JG, Dervieux T, Edick MJ, Mehta PK, Rubnitz JE, Shurtleff S, Raimondi SC, Behm FG, Pui CH, Relling MV
Proc Natl Acad Sci U S A 2001 Aug 28;98(18):10338-43
PMID 11526240
 
Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement
Shih LY, Liang DC, Fu JF, Wu JH, Wang PN, Lin TL, Dunn P, Kuo MC, Tang TC, Lin TH, Lai CL
Leukemia 2006 Feb;20(2):218-23
PMID 16341046
 
Analysis of acute leukemias with MLL/ENL fusion transcripts: identification of two novel breakpoints in ENL
Fu JF, Liang DC, Shih LY
Am J Clin Pathol 2007 Jan;127(1):24-30
PMID 17145626
 
Analysis of acute leukemias with MLL/ENL fusion transcripts: identification of two novel breakpoints in ENL
Fu JF, Liang DC, Shih LY
Am J Clin Pathol 2007 Jan;127(1):24-30
PMID 17145626
 
Mixed phenotype acute leukemia with t(11;19)(q23;p13
Naghashpour M, Lancet J, Moscinski L, Zhang L
3)/ MLL-MLLT1(ENL), B/T-lymphoid type: A first case report Am J Hematol
PMID 20513125
 
The first case of blastic plasmacytoid dendritic cell neoplasm with MLL-ENL rearrangement
Toya T, Nishimoto N, Koya J, Nakagawa M, Nakamura F, Kandabashi K, Yamamoto G, Nannya Y, Ichikawa M, Kurokawa M
Leuk Res 2012 Jan;36(1):117-8
PMID 21831428
 
Genetic and clinical characterization of 45 acute leukemia patients with MLL gene rearrangements from a single institution
Cerveira N, Lisboa S, Correia C, Bizarro S, Santos J, Torres L, Vieira J, Barros-Silva JD, Pereira D, Moreira C, Meyer C, Oliva T, Moreira I, Martins Â, Viterbo L, Costa V, Marschalek R, Pinto A, Mariz JM, Teixeira MR
Mol Oncol 2012 Oct;6(5):553-64
PMID 22846743
 
KMT2A (MLL)-MLLT1 rearrangement in blastic plasmacytoid dendritic cell neoplasm
Yang N, Huh J, Chung WS, Cho MS, Ryu KH, Chung HS
Cancer Genet 2015 Sep;208(9):464-7
PMID 26164398
 
A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities
Yamamoto K, Seto M, Iida S, Komatsu H, Kamada N, Kojima S, Kodera Y, Nakazawa S, Saito H, Takahashi T, et al
Blood 1994 May 15;83(10):2912-21
PMID 8180386
 
Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia
Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T, et al
Oncogene 1993 Oct;8(10):2617-25
PMID 8378076
 
Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL
Lavau C, Szilvassy SJ, Slany R, Cleary ML
EMBO J 1997 Jul 16;16(14):4226-37
PMID 9250666
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;19)(q23;p13) KMT2A/MLLT1

External links

KMT2A (11q23.3) MLLT1 (19p13.3)

Mitelman databaset(11;19)(q23;p13) [Case List]    t(11;19)(q23;p13) [Transloc-MCList] KMT2A/MLLT1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Nov 6 14:08:07 CET 2018


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