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t(11;20)(p15;q12) NUP98/TOP1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3481
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute monoblastic leukemia (FAB type M5)|Acute monoblastic leukemia with differentiation (FAB type M5b)|Acute myeloblastic leukemia with maturation (FAB type M2)|Acute myeloblastic leukemia without maturation (FAB type M1)|Acute myeloid leukemia, NOS|Acute myelomonocytic leukemia (FAB type M4)|Refractory anemia with excess of blasts (FAB)

Genes involved and Proteins

Gene NameNUP98
Location 11p15.4
Gene NameTOP1
Location 20q12

Bibliography

The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion
Ahuja HG, Felix CA, Aplan PD
Blood 1999 Nov 1;94(9):3258-61
PMID 10556215
 
The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion
Ahuja HG, Felix CA, Aplan PD
Blood 1999 Nov 1;94(9):3258-61
PMID 10556215
 
Screening for NUP98 rearrangements in hematopoietic malignancies by fluorescence in situ hybridization
Nebral K, König M, Schmidt HH, Lutz D, Sperr WR, Kalwak K, Brugger S, Dworzak MN, Haas OA, Strehl S
Haematologica 2005 Jun;90(6):746-52
PMID 15951287
 
Generation of the NUP98-TOP1 fusion transcript by the t(11;20) (p15;q11) in a case of acute monocytic leukemia
Chen S, Xue Y, Chen Z, Guo Y, Wu Y, Pan J
Cancer Genet Cytogenet 2003 Jan 15;140(2):153-6
PMID 12645654
 
Both NUP98/TOP1 and TOP1/NUP98 transcripts are detected in a de novo AML with t(11;20)(p15;q11)
Iwase S, Akiyama N, Sekikawa T, Saito S, Arakawa Y, Horiguchi-Yamada J, Yamada H
Genes Chromosomes Cancer 2003 Sep;38(1):102-5
PMID 12874791
 
A t(11;20)(p15;q11) may identify a subset of nontherapy-related acute myelocytic leukemia
Potenza L, Sinigaglia B, Luppi M, Morselli M, Saviola A, Ferrari A, Riva G, Zucchini P, Giacobbi F, Emilia G, Temperani P, Torelli G
Cancer Genet Cytogenet 2004 Mar;149(2):164-8
PMID 15036893
 
Analysis of translocations that involve the NUP98 gene in patients with 11p15 chromosomal rearrangements
Kobzev YN, Martinez-Climent J, Lee S, Chen J, Rowley JD
Genes Chromosomes Cancer 2004 Dec;41(4):339-52
PMID 15390187
 
NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique
Romana SP, Radford-Weiss I, Ben Abdelali R, Schluth C, Petit A, Dastugue N, Talmant P, Bilhou-Nabera C, Mugneret F, Lafage-Pochitaloff M, Mozziconacci MJ, Andrieu J, Lai JL, Terre C, Rack K, Cornillet-Lefebvre P, Luquet I, Nadal N, Nguyen-Khac F, Perot C, Van den Akker J, Fert-Ferrer S, Cabrol C, Charrin C, Tigaud I, Poirel H, Vekemans M, Bernard OA, Berger R; Groupe Francophone de Cytogénétique Hématologique
Leukemia 2006 Apr;20(4):696-706
PMID 16467868
 
NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern
Hollink IH, van den Heuvel-Eibrink MM, Arentsen-Peters ST, Pratcorona M, Abbas S, Kuipers JE, van Galen JF, Beverloo HB, Sonneveld E, Kaspers GJ, Trka J, Baruchel A, Zimmermann M, Creutzig U, Reinhardt D, Pieters R, Valk PJ, Zwaan CM
Blood 2011 Sep 29;118(13):3645-56
PMID 21813447
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;20)(p15;q12) NUP98/TOP1

External links

NUP98 (11p15.4) TOP1 (20q12)

Mitelman databaset(11;20)(p15;q12) [Case List]    t(11;20)(p15;q12) [Transloc-MCList] NUP98/TOP1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Jul 9 10:15:36 CEST 2018


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