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t(11;21)(q12;q22) RUNX1/LPXN

Written2018-01Jean-Loup Huret, Philippe Dessen

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Atlas_Id 3483
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute myeloid leukemia, NOS

Genes involved and Proteins

Gene NameRUNX1
Location 21q22.12
Gene NameLPXN
Location 11q12.1


LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation
Dai HP, Xue YQ, Zhou JW, Li AP, Wu YF, Pan JL, Wang Y, Zhang J
Genes Chromosomes Cancer 2009 Dec;48(12):1027-36
PMID 19760607

Translocations implicated (Data extracted from papers in the Atlas)

 t(11;21)(q12;q22) RUNX1/LPXN

External links

RUNX1 (21q22.12) LPXN (11q12.1)

Mitelman databaset(11;21)(q12;q22) [Case List]    t(11;21)(q12;q22) [Transloc-MCList] RUNX1/LPXN [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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