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t(11;22)(q23;q11) KMT2A/SEPT5

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3484
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Acute monoblastic leukemia (FAB type M5)|Acute myeloblastic leukemia with maturation (FAB type M2)|Acute myeloblastic leukemia without maturation (FAB type M1)|Acute myeloid leukemia, NOS

Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameSEPT5
Location 22q11.21

Bibliography

The CDCREL1 gene fused to MLL in de novo acute myeloid leukemia with t(11;22)(q23;q11
Tatsumi K, Taki T, Taniwaki M, Nakamura H, Taguchi J, Chen YZ, Bessho F, Yanagisawa M, Hayashi Y
2) and its frequent expression in myeloid leukemia cell lines Genes Chromosomes Cancer
PMID 11170279
 
t(11;22)(q23;q11
Megonigal MD, Rappaport EF, Jones DH, Williams TM, Lovett BD, Kelly KM, Lerou PH, Moulton T, Budarf ML, Felix CA
2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes Proc Natl Acad Sci U S A
PMID 9600980
 
The MLL recombinome of acute leukemias in 2013
Meyer C, Hofmann J, Burmeister T, Gröger D, Park TS, Emerenciano M, Pombo de Oliveira M, Renneville A, Villarese P, Macintyre E, Cavé H, Clappier E, Mass-Malo K, Zuna J, Trka J, De Braekeleer E, De Braekeleer M, Oh SH, Tsaur G, Fechina L, van der Velden VH, van Dongen JJ, Delabesse E, Binato R, Silva ML, Kustanovich A, Aleinikova O, Harris MH, Lund-Aho T, Juvonen V, Heidenreich O, Vormoor J, Choi WW, Jarosova M, Kolenova A, Bueno C, Menendez P, Wehner S, Eckert C, Talmant P, Tondeur S, Lippert E, Launay E, Henry C, Ballerini P, Lapillone H, Callanan MB, Cayuela JM, Herbaux C, Cazzaniga G, Kakadiya PM, Bohlander S, Ahlmann M, Choi JR, Gameiro P, Lee DS, Krauter J, Cornillet-Lefebvre P, Te Kronnie G, Schäfer BW, Kubetzko S, Alonso CN, zur Stadt U, Sutton R, Venn NC, Izraeli S, Trakhtenbrot L, Madsen HO, Archer P, Hancock J, Cerveira N, Teixeira MR, Lo Nigro L, Möricke A, Stanulla M, Schrappe M, Sedék L, Szczepański T, Zwaan CM, Coenen EA, van den Heuvel-Eibrink MM, Strehl S, Dworzak M, Panzer-Grümayer R, Dingermann T, Klingebiel T, Marschalek R
Leukemia 2013 Nov;27(11):2165-76
PMID 23628958
 
MLL-SEPT5 fusion transcript in infant acute myeloid leukemia with t(11;22)(q23;q11)
Launay E, Henry C, Meyer C, Chappé C, Taque S, Boulland ML, Ben Abdelali R, Dugay F, Marschalek R, Bastard C, Fest T, Gandemer V, Belaud-Rotureau MA
Leuk Lymphoma 2014 Mar;55(3):662-7
PMID 23725386
 
t(11;22)(q23;q11
Megonigal MD, Rappaport EF, Jones DH, Williams TM, Lovett BD, Kelly KM, Lerou PH, Moulton T, Budarf ML, Felix CA
2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes Proc Natl Acad Sci U S A
PMID 9600980
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;22)(q23;q11) KMT2A/SEPT5

External links

KMT2A (11q23.3) SEPT5 (22q11.21)

Mitelman databaset(11;22)(q23;q11) [Case List]    t(11;22)(q23;q11) [Transloc-MCList] KMT2A/SEPT5 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Aug 28 18:22:00 CEST 2018


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