Identity |
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
Atlas_Id | 3176 |
Note | Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to How to contribute |
Clinics and Pathology |
Disease | Acute lymphoblastic leukemia/lymphoblastic lymphoma |
Genes involved and Proteins |
Gene Name | RUNX1 |
Location | 21q22.12 |
Gene Name | PTHLH |
Location | 12p11.22 |
Bibliography |
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia |
Lilljebjörn H, Henningsson R, Hyrenius-Wittsten A, Olsson L, Orsmark-Pietras C, von Palffy S, Askmyr M, Rissler M, Schrappe M, Cario G, Castor A, Pronk CJ, Behrendtz M, Mitelman F, Johansson B, Paulsson K, Andersson AK, Fontes M, Fioretos T |
Nat Commun 2016 Jun 6;7:11790 |
PMID 27265895 |
Translocations implicated (Data extracted from papers in the Atlas) |
t(12;21)(p11;q22) RUNX1/PTHLH | |
External links |
Mitelman database | t(12;21)(p11;q22) |
COSMIC | Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC) |
arrayMap (UZH-SIB Zurich) | [select an item] |
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:28:52 CET 2020 |
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