t(12;21)(p11;q22) RUNX1/PTHLH

Identity

ICD-Topo	C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id	3176
Note	Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene Name	RUNX1
Location	21q22.12

Gene Name	PTHLH
Location	12p11.22

Bibliography

Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia

Lilljebjörn H, Henningsson R, Hyrenius-Wittsten A, Olsson L, Orsmark-Pietras C, von Palffy S, Askmyr M, Rissler M, Schrappe M, Cario G, Castor A, Pronk CJ, Behrendtz M, Mitelman F, Johansson B, Paulsson K, Andersson AK, Fontes M, Fioretos T

Nat Commun 2016 Jun 6;7:11790

PMID 27265895

Translocations implicated (Data extracted from papers in the Atlas)

	t(12;21)(p11;q22) RUNX1/PTHLH

External links

RUNX1 (21q22.12) PTHLH (12p11.22)

Mitelman database	t(12;21)(p11;q22) [Case List]    t(12;21)(p11;q22) [Transloc-MCList] RUNX1/PTHLH [Fusion-MCList]
COSMIC	Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)	[select an item]

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
All articles	automatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Tue Aug 28 18:22:10 CEST 2018

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