Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(12;21)(p13;q22) RUNX1/DDX47

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3162

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameRUNX1
Location 21q22.12
Gene NameDDX47
Location 12p13.1

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Low frequency of TEL-AML1 in relapsed acute lymphoblastic leukemia supports a favorable prognosis for this genetic subgroup
Rubnitz JE, Behm FG, Wichlan D, Ryan C, Sandlund JT, Ribeiro RC, Rivera GK, Hancock ML, Relling MV, Evans WE, Pui CH, Downing JR
Leukemia 1999 Jan;13(1):19-21
PMID 10049054
 
TEL/AML1 positivity in childhood ALL: average or better prognosis? Czech Paediatric Haematology Working Group
Zuna J, Hrusák O, Kalinová M, Muzíková K, Starý J, Trka J
Leukemia 1999 Jan;13(1):22-4
PMID 10049055
 
TEL-AML1 fusion transcript designates a favorable outcome with an intensified protocol in childhood acute lymphoblastic leukemia
Avigad S, Kuperstein G, Zilberstein J, Liberzon E, Stark B, Gelernter I, Kodman Y, Luria D, Ash S, Stein J, Goshen Y, Yaniv I, Cohen IJ, Zaizov R
Leukemia 1999 Mar;13(3):481-3
PMID 10086740
 
An investigation of the t(12;21) rearrangement in children with B-precursor acute lymphoblastic leukaemia using cytogenetic and molecular methods
Kempski H, Chalker J, Chessells J, Sturt N, Brickell P, Webb J, Clink JM, Reeves B
Br J Haematol 1999 Jun;105(3):684-9
PMID 10354132
 
TEL-AML1 positivity in relapsed B cell precursor acute lymphoblastic leukemia in childhood
Seeger K, Buchwald D, Taube T, Peter A, von Stackelberg A, Schmitt G, Köchling J, Henze G
Berlin-Frankfurt-Münster Study Group Leukemia
PMID 10483004
 
TEL-AML1 fusion identifies a subset of children with standard risk acute lymphoblastic leukemia who have an excellent prognosis when treated with therapy that includes a single delayed intensification
Maloney K, McGavran L, Murphy J, Odom L, Stork L, Wei Q, Hunger S
Leukemia 1999 Nov;13(11):1708-12
PMID 10557042
 
TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia
Ramakers-van Woerden NL, Pieters R, Loonen AH, Hubeek I, van Drunen E, Beverloo HB, Slater RM, Harbott J, Seyfarth J, van Wering ER, Hählen K, Schmiegelow K, Janka-Schaub GE, Veerman AJ
Blood 2000 Aug 1;96(3):1094-9
PMID 10910927
 
Cytogenetic and FISH studies of a single center consecutive series of 152 childhood acute lymphoblastic leukemias
Andreasson P, Höglund M, Békássy AN, Garwicz S, Heldrup J, Mitelman F, Johansson B
Eur J Haematol 2000 Jul;65(1):40-51
PMID 10914938
 
TEL-AML1 fusion gene frequency in paediatric acute lymphoblastic leukaemia in Brazil
Magalhães IQ, Pombo-de-Oliveira MS, Bennett CA, Cordoba JC, Dobbin J, Ford AM, Greaves MF
Br J Haematol 2000 Oct;111(1):204-7
PMID 11091202
 
TEL/AML-1 fusion gene
Jamil A, Theil KS, Kahwash S, Ruymann FB, Klopfenstein KJ
its frequency and prognostic significance in childhood acute lymphoblastic leukemia Cancer Genet Cytogenet
PMID 11106814
 
Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol
Hann I, Vora A, Harrison G, Harrison C, Eden O, Hill F, Gibson B, Richards S; UK Medical Research Council's Working Party on Childhood Leukaemia
Br J Haematol 2001 Apr;113(1):103-14
PMID 11328289
 
TEL/AML1 fusion is not a prognostic factor in Dutch childhood acute lymphoblastic leukaemia
Hubeek I, Ramakers-van Woerden NL, Pieters R, Slater R, Beverloo HB, van Wering ER, Kamps W, Hählen K, Veerman AJ
Br J Haematol 2001 Apr;113(1):254-5
PMID 11328310
 
Relapse of TEL-AML1--positive acute lymphoblastic leukemia in childhood: a matched-pair analysis
Seeger K, von Stackelberg A, Taube T, Buchwald D, Körner G, Suttorp M, Dörffel W, Tausch W, Henze G
J Clin Oncol 2001 Jul 1;19(13):3188-93
PMID 11432885
 
TEL/AML1 rearrangement and the prognostic significance in childhood acute lymphoblastic leukemia in Hong Kong
Tsang KS, Li CK, Chik KW, Shing MM, Tsoi WC, Ng MH, Lau TT, Leung Y, Yuen PM
Am J Hematol 2001 Oct;68(2):91-8
PMID 11559948
 
Fluorescence in situ hybridization study of TEL/AML1 fusion and other abnormalities involving TEL and AML1 genes
Martínez-Ramírez A, Urioste M, Contra T, Cantalejo A, Tavares A, Portero JA, López-Ibor B, Bernacer M, Soto C, Cigudosa JC, Benítez J
Correlation with cytogenetic findings and prognostic value in children with acute lymphocytic leukemia Haematologica
PMID 11726315
 
Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey
Ozbek U, Sirma S, Agaoglu L, Yuksel L, Anak S, Yildiz I, Devecioglu O, Timur C, Meral A, Gedikoglu G
J Pediatr Hematol Oncol 2003 Mar;25(3):204-8
PMID 12621238
 
Favorable outcome in 20-year follow-up of children with very-low-risk ALL and minimal standard therapy, with special reference to TEL-AML1 fusion
Kanerva J, Saarinen-Pihkala UM, Niini T, Riikonen P, Möttönen M, Mäkipernaa A, Salmi TT, Vettenranta K, Knuutila S
Pediatr Blood Cancer 2004 Jan;42(1):30-5
PMID 14752791
 
Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia
Frost BM, Forestier E, Gustafsson G, Nygren P, Hellebostad M, Jonsson OG, Kanerva J, Schmiegelow K, Larsson R, Lönnerholm G
Blood 2004 Oct 15;104(8):2452-7
PMID 15217836
 
High frequency of t(12;21)(p13;q22) in children with acute lymphoblastic leukemia and known clinical outcome in southern Brazil
Veiga LB, Cóser VM, Cavalli LR, Cavalli IJ, Rodrigues JN, Pereira WV, Pereira DV, Lafayette TC, Villalba BT, Moreira ME, Haddad BR, de Souza Fonseca Ribeiro EM
Leuk Res 2004 Oct;28(10):1033-8
PMID 15289014
 
Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis
Attarbaschi A, Mann G, König M, Dworzak MN, Trebo MM, Mühlegger N, Gadner H, Haas OA; Austrian Berlin-Frankfurt-Münster cooperative study group
Leukemia 2004 Oct;18(10):1611-6
PMID 15356655
 
Equal frequency of TEL/AML1 rearrangements in children with acute lymphoblastic leukemia with and without Down syndrome
Steiner M, Attarbaschi A, König M, Nebral K, Gadner H, Haas OA, Mann G; Austrian Berlin-Frankfurt-Münster Group
Pediatr Hematol Oncol 2005 Apr-May;22(3):229-34
PMID 16020107
 
Genetic abnormalities associated with the t(12;21) and their impact in the outcome of 56 patients with B-precursor acute lymphoblastic leukemia
Alvarez Y, Coll MD, Ortega JJ, Bastida P, Dastugue N, Robert A, Cervera J, Verdeguer A, Tasso M, Aventín A, Guitart M, Caballín MR
Cancer Genet Cytogenet 2005 Oct 1;162(1):21-9
PMID 16157196
 
Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome
Stams WA, Beverloo HB, den Boer ML, de Menezes RX, Stigter RL, van Drunen E, Ramakers-van-Woerden NL, Loonen AH, van Wering ER, Janka-Schaub GE, Pieters R
Leukemia 2006 Mar;20(3):410-6
PMID 16424874
 
Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01
Loh ML, Goldwasser MA, Silverman LB, Poon WM, Vattikuti S, Cardoso A, Neuberg DS, Shannon KM, Sallan SE, Gilliland DG
Blood 2006 Jun 1;107(11):4508-13
PMID 16493009
 
Characteristics of patients with TEL-AML1-positive acute lymphoblastic leukemia with single or multiple fusions
Al-Sweedan SA, Neglia JP, Steiner ME, Bostrom BC, Casey T, Hirsch BA
Pediatr Blood Cancer 2007 May;48(5):510-4
PMID 16763978
 
High incidence of the ETV6/RUNX1 fusion gene in paediatric precursor B-cell acute lymphoblastic leukaemias with trisomy 21 as the sole cytogenetic change: a Nordic series of cases diagnosed 1989-2005
Karrman K, Forestier E, Andersen MK, Autio K, Borgström G, Heim S, Heinonen K, Hovland R, Kerndrup G, Johansson B; Nordic Society of Paediatric Haematology and Oncology (NOPHO) and the NOPHO Leukaemia Cytogenetic Study Group (NLCSG)
Br J Haematol 2006 Nov;135(3):352-4
PMID 16965388
 
Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG)
Schultz KR, Pullen DJ, Sather HN, Shuster JJ, Devidas M, Borowitz MJ, Carroll AJ, Heerema NA, Rubnitz JE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Gaynon PS, Camitta BM
Blood 2007 Feb 1;109(3):926-35
PMID 17003380
 
Deletion of 11q23 is a highly specific nonrandom secondary genetic abnormality of ETV6/RUNX1-rearranged childhood acute lymphoblastic leukemia
Attarbaschi A, Mann G, Strehl S, König M, Steiner M, Jeitler V, Lion T, Dworzak MN, Gadner H, Haas OA
Leukemia 2007 Mar;21(3):584-6
PMID 17215856
 
Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival
Forestier E, Heyman M, Andersen MK, Autio K, Blennow E, Borgström G, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Rosenquist R, Swolin B, Johansson B; Nordic Society of Paediatric Haematology, Oncology (NOPHO); Swedish Cytogenetic Leukaemia Study Group (SCLSG); NOPHO Leukaemia Cytogenetic Study Group (NLCSG)
Br J Haematol 2008 Mar;140(6):665-72
PMID 18241254
 
Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study
Borowitz MJ, Devidas M, Hunger SP, Bowman WP, Carroll AJ, Carroll WL, Linda S, Martin PL, Pullen DJ, Viswanatha D, Willman CL, Winick N, Camitta BM; Children's Oncology Group
Blood 2008 Jun 15;111(12):5477-85
PMID 18388178
 
Acute lymphoblastic leukemia in adolescents and young adults in Finland
Usvasalo A, Räty R, Knuutila S, Vettenranta K, Harila-Saari A, Jantunen E, Kauppila M, Koistinen P, Parto K, Riikonen P, Salmi TT, Silvennoinen R, Elonen E, Saarinen-Pihkala UM
Haematologica 2008 Aug;93(8):1161-8
PMID 18556413
 
The application of conventional cytogenetics, FISH, and RT-PCR to detect genetic changes in 70 children with ALL
Soszynska K, Mucha B, Debski R, Skonieczka K, Duszenko E, Koltan A, Wysocki M, Haus O
Ann Hematol 2008 Dec;87(12):991-1002
PMID 18633615
 
Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia
Burmeister T, Gökbuget N, Schwartz S, Fischer L, Hubert D, Sindram A, Hoelzer D, Thiel E
Haematologica 2010 Feb;95(2):241-6
PMID 19713226
 
Cytogenetics of long-term survivors of ETV6-RUNX1 fusion positive acute lymphoblastic leukemia
Konn ZJ, Martineau M, Bown N, Richards S, Swansbury J, Talley P, Wright SL, Harrison CJ
Genes Chromosomes Cancer 2010 Mar;49(3):253-9
PMID 19998443
 
Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia
Pui CH, Pei D, Sandlund JT, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Campana D, Kun LE, Jeha S, Cheng C, Howard SC, Metzger ML, Bhojwani D, Downing JR, Evans WE, Relling MV
Leukemia 2010 Feb;24(2):371-82
PMID 20010620
 
Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001
Mitchell C, Richards S, Harrison CJ, Eden T
Leukemia 2010 Feb;24(2):406-18
PMID 20010621
 
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia
Schmiegelow K, Forestier E, Hellebostad M, Heyman M, Kristinsson J, Söderhäll S, Taskinen M; Nordic Society of Paediatric Haematology and Oncology
Leukemia 2010 Feb;24(2):345-54
PMID 20010622
 
Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the children's oncology group
Salzer WL, Devidas M, Carroll WL, Winick N, Pullen J, Hunger SP, Camitta BA
Leukemia 2010 Feb;24(2):355-70
PMID 20016527
 
Long-term results of the Israeli National Studies in childhood acute lymphoblastic leukemia: INS 84, 89 and 98
Stark B, Nirel R, Avrahami G, Abramov A, Attias D, Ballin A, Bielorai B, Burstein Y, Gavriel H, Elhasid R, Kapelushnik J, Sthoeger D, Toren A, Wientraub M, Yaniv I, Izraeli S
Leukemia 2010 Feb;24(2):419-24
PMID 20016534
 
Long-term results of treatment of childhood acute lymphoblastic leukemia in the Czech Republic
Stary J, Jabali Y, Trka J, Hrusak O, Gajdos P, Hrstkova H, Sterba J, Blazek B, Hak J, Prochazkova D, Cerna Z, Smisek P, Sedlacek P, Vavra V, Mihal V, Hrodek O; Czech Pediatric Hematology working group
Leukemia 2010 Feb;24(2):425-8
PMID 20016535
 
Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia
Liang DC, Yang CP, Lin DT, Hung IJ, Lin KH, Chen JS, Hsiao CC, Chang TT, Peng CT, Lin MT, Chang TK, Jaing TH, Liu HC, Wang LY, Yeh TC, Jou ST, Lu MY, Cheng CN, Sheen JM, Chiou SS, Wu KH, Hung GY, Chen RL, Chen SH, Cheng SN, Chang YH, Chen BW, Ho WL, Wang JL, Lin ST, Hsieh YL, Wang SC, Chang HH, Yang YL, Huang FL, Chang CY, Chang WH, Lin KS
Leukemia 2010 Feb;24(2):397-405
PMID 20016538
 
Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial
Moorman AV, Ensor HM, Richards SM, Chilton L, Schwab C, Kinsey SE, Vora A, Mitchell CD, Harrison CJ
Lancet Oncol 2010 May;11(5):429-38
PMID 20409752
 
Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: a report from the Children's Oncology Group
Maloney KW, Carroll WL, Carroll AJ, Devidas M, Borowitz MJ, Martin PL, Pullen J, Whitlock JA, Willman CL, Winick NJ, Camitta BM, Hunger SP
Blood 2010 Aug 19;116(7):1045-50
PMID 20442364
 
Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy
Sinclair PB, Parker H, An Q, Rand V, Ensor H, Harrison CJ, Strefford JC
Hum Mol Genet 2011 Jul 1;20(13):2591-602
PMID 21487021
 
ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy
Bhojwani D, Pei D, Sandlund JT, Jeha S, Ribeiro RC, Rubnitz JE, Raimondi SC, Shurtleff S, Onciu M, Cheng C, Coustan-Smith E, Bowman WP, Howard SC, Metzger ML, Inaba H, Leung W, Evans WE, Campana D, Relling MV, Pui CH
Leukemia 2012 Feb;26(2):265-70
PMID 21869842
 
Additional aberrations of the ETV6 and RUNX1 genes have no prognostic impact in 229 t(12;21)(p13;q22)-positive B-cell precursor acute lymphoblastic leukaemias treated according to the NOPHO-ALL-2000 protocol
Barbany G, Andersen MK, Autio K, Borgström G, Franco LC, Golovleva I, Heim S, Heinonen K, Hovland R, Johansson B, Johannsson JH, Kjeldsen E, Nordgren A, Palmqvist L, Forestier E; Nordic Society of Paediatric Haematology and Oncology; Swedish Cytogenetic Leukaemia Study Group; NOPHO Leukaemia Cytogenetic Study Group
Leuk Res 2012 Jul;36(7):936-8
PMID 22521551
 
Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia
Krentz S, Hof J, Mendioroz A, Vaggopoulou R, Dörge P, Lottaz C, Engelmann JC, Groeneveld TW, Körner G, Seeger K, Hagemeier C, Henze G, Eckert C, von Stackelberg A, Kirschner-Schwabe R
Leukemia 2013 Feb;27(2):295-304
PMID 22699455
 
Clinical features, early treatment responses, and outcomes of pediatric acute lymphoblastic leukemia in China with or without specific fusion transcripts: a single institutional study of 1,004 patients
Gao C, Zhao XX, Li WJ, Cui L, Zhao W, Liu SG, Yue ZX, Jiao Y, Wu MY, Li ZG
Am J Hematol 2012 Nov;87(11):1022-7
PMID 22911440
 
Long-term follow-up of ETV6-RUNX1 ALL reveals that NCI risk, rather than secondary genetic abnormalities, is the key risk factor
Enshaei A, Schwab CJ, Konn ZJ, Mitchell CD, Kinsey SE, Wade R, Vora A, Harrison CJ, Moorman AV
Leukemia 2013 Nov;27(11):2256-9
PMID 23636228
 
Childhood high-risk acute lymphoblastic leukemia in first remission: results after chemotherapy or transplant from the AIEOP ALL 2000 study
Conter V, Valsecchi MG, Parasole R, Putti MC, Locatelli F, Barisone E, Lo Nigro L, Santoro N, Aricò M, Ziino O, Pession A, Testi AM, Micalizzi C, Casale F, Zecca M, Casazza G, Tamaro P, La Barba G, Notarangelo LD, Silvestri D, Colombini A, Rizzari C, Biondi A, Masera G, Basso G
Blood 2014 Mar 6;123(10):1470-8
PMID 24415536
 
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia
Lilljebjörn H, Henningsson R, Hyrenius-Wittsten A, Olsson L, Orsmark-Pietras C, von Palffy S, Askmyr M, Rissler M, Schrappe M, Cario G, Castor A, Pronk CJ, Behrendtz M, Mitelman F, Johansson B, Paulsson K, Andersson AK, Fontes M, Fioretos T
Nat Commun 2016 Jun 6;7:11790
PMID 27265895
 
Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia
Liu YF, Wang BY, Zhang WN, Huang JY, Li BS, Zhang M, Jiang L, Li JF, Wang MJ, Dai YJ, Zhang ZG, Wang Q, Kong J, Chen B, Zhu YM, Weng XQ, Shen ZX, Li JM, Wang J, Yan XJ, Li Y, Liang YM, Liu L, Chen XQ, Zhang WG, Yan JS, Hu JD, Shen SH, Chen J, Gu LJ, Pei D, Li Y, Wu G, Zhou X, Ren RB, Cheng C, Yang JJ, Wang KK, Wang SY, Zhang J, Mi JQ, Pui CH, Tang JY, Chen Z, Chen SJ
EBioMedicine 2016 Jun;8:173-183
PMID 27428428
 
Analysis of common cytogenetic abnormalities in New Zealand pediatric ALL shows ethnically diverse carriage of ETV6-RUNX1, without a corresponding difference in survival
Pettit T, Cole N, Leung W, Ballantine K, Macfarlane S
Pediatr Blood Cancer 2017 Dec;64(12)
PMID 28598545
 
High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia
Romana SP, Poirel H, Leconiat M, Flexor MA, Mauchauffé M, Jonveaux P, Macintyre EA, Berger R, Bernard OA
Blood 1995 Dec 1;86(11):4263-9
PMID 7492786
 
Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia
Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG
Proc Natl Acad Sci U S A 1995 May 23;92(11):4917-21
PMID 7761424
 
The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion
Romana SP, Mauchauffé M, Le Coniat M, Chumakov I, Le Paslier D, Berger R, Bernard OA
Blood 1995 Jun 15;85(12):3662-70
PMID 7780150
 
TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis
Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML, Chan GC, Pui CH, Grosveld G, Downing JR
Leukemia 1995 Dec;9(12):1985-9
PMID 8609706
 
Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia
Lanza C, Volpe G, Basso G, Gottardi E, Barisone E, Spinelli M, Ricotti E, Cilli V, Perfetto F, Madon E, Saglio G
Br J Haematol 1997 May;97(2):460-2
PMID 9163615
 
Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials
Borkhardt A, Cazzaniga G, Viehmann S, Valsecchi MG, Ludwig WD, Burci L, Mangioni S, Schrappe M, Riehm H, Lampert F, Basso G, Masera G, Harbott J, Biondi A
Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Study Group Blood
PMID 9226156
 
12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia
Raimondi SC, Shurtleff SA, Downing JR, Rubnitz J, Mathew S, Hancock M, Pui CH, Rivera GK, Grosveld GC, Behm FG
Blood 1997 Dec 1;90(11):4559-66
PMID 9373267
 
Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse
Harbott J, Viehmann S, Borkhardt A, Henze G, Lampert F
Blood 1997 Dec 15;90(12):4933-7
PMID 9389711
 
TEL-AML1 fusion transcript in relapsed childhood acute lymphoblastic leukemia
Seeger K, Adams HP, Buchwald D, Beyermann B, Kremens B, Niemeyer C, Ritter J, Schwabe D, Harms D, Schrappe M, Henze G
The Berlin-Frankfurt-Münster Study Group Blood
PMID 9473238
 
Prognostic significance of TEL/AML1 fusion transcript in childhood B-precursor acute lymphoblastic leukemia
Takahashi Y, Horibe K, Kiyoi H, Miyashita Y, Fukuda M, Mori H, Nozaki C, Hasegawa S, Kawabe T, Kato K, Kojima S, Matuyama T, Naoe T
J Pediatr Hematol Oncol 1998 May-Jun;20(3):190-5
PMID 9628428
 
Impact of TEL/AML1-positive patients on age distribution of childhood acute lymphoblastic leukemia in Czech Republic
Trka J, Zuna J, Hrusák O, Kalinová M, Muzíková K, Lauschman H, Starý J
Pediatric Hematology Working Group in Czech Republic Leukemia
PMID 9639432
 
Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TEL-AML1 negativity
Hrusák O, Trka J, Zuna J, Housková J, Bartůnková J, Starý J
The Pediatric Hematology Working Group in the Czech Republic Leukemia
PMID 9665191
 
Surface antigen phenotype can predict TEL-AML1 rearrangement in childhood B-precursor ALL: a Pediatric Oncology Group study
Borowitz MJ, Rubnitz J, Nash M, Pullen DJ, Camitta B
Leukemia 1998 Nov;12(11):1764-70
PMID 9823952
 
Incidence of TEL/AML1 fusion in children with relapsed acute lymphoblastic leukemia
Loh ML, Silverman LB, Young ML, Neuberg D, Golub TR, Sallan SE, Gilliland DG
Blood 1998 Dec 15;92(12):4792-7
PMID 9845546
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(12;21)(p13;q22) RUNX1/DDX47

External links

RUNX1 (21q22.12) DDX47 (12p13.1)

Mitelman databaset(12;21)(p13;q22) [Case List]    t(12;21)(p13;q22) [Transloc-MCList] RUNX1/DDX47 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jan 10 17:22:51 CET 2018


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.