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t(12;21)(p13;q22) RUNX1/ETV6

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3165
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameRUNX1
Location 21q22.12
Gene NameETV6
Location 12p13.2

Bibliography

Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia
Lilljebjörn H, Henningsson R, Hyrenius-Wittsten A, Olsson L, Orsmark-Pietras C, von Palffy S, Askmyr M, Rissler M, Schrappe M, Cario G, Castor A, Pronk CJ, Behrendtz M, Mitelman F, Johansson B, Paulsson K, Andersson AK, Fontes M, Fioretos T
Nat Commun 2016 Jun 6;7:11790
PMID 27265895
 
Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia
Liu YF, Wang BY, Zhang WN, Huang JY, Li BS, Zhang M, Jiang L, Li JF, Wang MJ, Dai YJ, Zhang ZG, Wang Q, Kong J, Chen B, Zhu YM, Weng XQ, Shen ZX, Li JM, Wang J, Yan XJ, Li Y, Liang YM, Liu L, Chen XQ, Zhang WG, Yan JS, Hu JD, Shen SH, Chen J, Gu LJ, Pei D, Li Y, Wu G, Zhou X, Ren RB, Cheng C, Yang JJ, Wang KK, Wang SY, Zhang J, Mi JQ, Pui CH, Tang JY, Chen Z, Chen SJ
EBioMedicine 2016 Jun;8:173-183
PMID 27428428
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(12;21)(p13;q22) RUNX1/ETV6

External links

RUNX1 (21q22.12) ETV6 (12p13.2)

Mitelman databaset(12;21)(p13;q22) [Case List]    t(12;21)(p13;q22) [Transloc-MCList] RUNX1/ETV6 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Aug 28 18:22:10 CEST 2018


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