t(12;21)(q12;q22) RUNX1/CPNE8

Identity

ICD-Topo	C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id	3161
Note	Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease

Acute myeloblastic leukemia with maturation (FAB type M2)

Genes involved and Proteins

Gene Name	RUNX1
Location	21q22.12

Gene Name	CPNE8
Location	12q12

Bibliography

Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation

Ramsey H, Zhang DE, Richkind K, Burcoglu-O'Ral A, Hromas R

Leukemia 2003 Aug;17(8):1665-6

PMID 12886257

Translocations implicated (Data extracted from papers in the Atlas)

	t(12;21)(q12;q22) RUNX1/CPNE8

External links

RUNX1 (21q22.12) CPNE8 (12q12)

Mitelman database	t(12;21)(q12;q22) [Case List]    t(12;21)(q12;q22) [Transloc-MCList] RUNX1/CPNE8 [Fusion-MCList]
COSMIC	Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)	[select an item]

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
All articles	automatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Tue Nov 6 14:08:23 CET 2018

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