| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| Atlas_Id | 3161 |
| Note | Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to How to contribute |
| Clinics and Pathology |
| Disease | Acute myeloblastic leukemia with maturation (FAB type M2) |
| Genes involved and Proteins |
| Gene Name | RUNX1 |
| Location | 21q22.12 |
| Gene Name | CPNE8 |
| Location | 12q12 |
| Bibliography |
| Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation |
| Ramsey H, Zhang DE, Richkind K, Burcoglu-O'Ral A, Hromas R |
| Leukemia 2003 Aug;17(8):1665-6 |
| PMID 12886257 |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(12;21)(q12;q22) RUNX1/CPNE8 | |
| External links |
| Mitelman database | t(12;21)(q12;q22) |
| COSMIC | Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC) |
| arrayMap (UZH-SIB Zurich) | [select an item] |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:28:53 CET 2020 |
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