Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(14;14)(q11;q32) IGH/CEBPE

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2791

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameCEBPE
Location 14q11.2

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia
Saitou M, Sugimoto J, Hatakeyama T, Russo G, Isobe M
Oncogene 2000 May 25;19(23):2796-802
PMID 10851082
 
IGH gene involvement in two cases of acute lymphoblastic leukemia with t(14;14)(q11;q32) identified by sequential R-banding and fluorescence in situ hybridization
Liu S, Bo L, Liu X, Li C, Qin S, Wang J
Cancer Genet Cytogenet 2004 Jul 15;152(2):141-5
PMID 15262434
 
Disruption of the BCL11B gene through inv(14)(q11
Przybylski GK, Dik WA, Wanzeck J, Grabarczyk P, Majunke S, Martin-Subero JI, Siebert R, Dölken G, Ludwig WD, Verhaaf B, van Dongen JJ, Schmidt CA, Langerak AW
2q32 31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL
PMID 15668700
 
Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
Akasaka T, Balasas T, Russell LJ, Sugimoto KJ, Majid A, Walewska R, Karran EL, Brown DG, Cain K, Harder L, Gesk S, Martin-Subero JI, Atherton MG, Brüggemann M, Calasanz MJ, Davies T, Haas OA, Hagemeijer A, Kempski H, Lessard M, Lillington DM, Moore S, Nguyen-Khac F, Radford-Weiss I, Schoch C, Struski S, Talley P, Welham MJ, Worley H, Strefford JC, Harrison CJ, Siebert R, Dyer MJ
Blood 2007 Apr 15;109(8):3451-61
PMID 17170124
 
Translocation (14;14)(q11;q32) with simultaneous involvement of the IGH and CEBPE genes in B-lineage acute lymphoblastic leukemia
Han Y, Xue Y, Zhang J, Wu Y, Pan J, Wang Y, Shen J, Dai H, Bai S
Cancer Genet Cytogenet 2008 Dec;187(2):125-9
PMID 19027493
 
Characterization of the breakpoint of a t(14;14)(q11
Bertness VL, Felix CA, McBride OW, Morgan R, Smith SD, Sandberg AA, Kirsch IR
2;q32) from the leukemic cells of a patient with T-cell acute lymphoblastic leukemia Cancer Genet Cytogenet
PMID 1967157
 
Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults
Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T, Mano H
Nat Genet 2016 May;48(5):569-74
PMID 27019113
 
Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia
Liu YF, Wang BY, Zhang WN, Huang JY, Li BS, Zhang M, Jiang L, Li JF, Wang MJ, Dai YJ, Zhang ZG, Wang Q, Kong J, Chen B, Zhu YM, Weng XQ, Shen ZX, Li JM, Wang J, Yan XJ, Li Y, Liang YM, Liu L, Chen XQ, Zhang WG, Yan JS, Hu JD, Shen SH, Chen J, Gu LJ, Pei D, Li Y, Wu G, Zhou X, Ren RB, Cheng C, Yang JJ, Wang KK, Wang SY, Zhang J, Mi JQ, Pui CH, Tang JY, Chen Z, Chen SJ
EBioMedicine 2016 Jun;8:173-183
PMID 27428428
 
A chromosome 14 inversion in a T-cell lymphoma is caused by site-specific recombination between immunoglobulin and T-cell receptor loci
Denny CT, Yoshikai Y, Mak TW, Smith SD, Hollis GF, Kirsch IR
Nature 1986 Apr 10-16;320(6062):549-51
PMID 3008004
 
Common mechanism of chromosome inversion in B- and T-cell tumors: relevance to lymphoid development
Denny CT, Hollis GF, Hecht F, Morgan R, Link MP, Smith SD, Kirsch IR
Science 1986 Oct 10;234(4773):197-200
PMID 3092355
 
Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors
Baer R, Chen KC, Smith SD, Rabbitts TH
Cell 1985 Dec;43(3 Pt 2):705-13
PMID 3935328
 
Concurrent presence of inv(14)(q11q32) and t(4;11)(q21;q23) in pre-B acute lymphoblastic leukemia
Chervinsky DS, Grossi M, Kakati S, Block AW, Aplan PD
Genes Chromosomes Cancer 1995 Mar;12(3):229-36
PMID 7536464
 
Chromosome walking on the TCL1 locus involved in T-cell neoplasia
Virgilio L, Isobe M, Narducci MG, Carotenuto P, Camerini B, Kurosawa N, Abbas-ar-Rushdi, Croce CM, Russo G
Proc Natl Acad Sci U S A 1993 Oct 15;90(20):9275-9
PMID 8415691
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(14;14)(q11;q32) IGH/CEBPE

External links

IGH (14q32.33) CEBPE (14q11.2)

Mitelman databaset(14;14)(q11;q32) [Case List]    t(14;14)(q11;q32) [Transloc-MCList] IGH/CEBPE [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jan 10 17:22:57 CET 2018


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.