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inv(14)(q11q32):t(14;14)(q11;q32) IGH/TRA

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 2814

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma:Angioimmunoblastic T-cell lymphoma:Mature T- and NK-cell neoplasm, NOS:T-prolymphocytic leukemia

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameTRA
Location 10q26.13

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


Immunoglobulin VH-T cell receptor C alpha fusion mRNA resulting from chromosome inversion include the T cell-associated 5' exon ET
Fisch P, Foroni L, Forster A, Lavenir I, Mengle-Gaw L, Rabbitts TH
Eur J Immunol 1992 Oct;22(10):2745-8
PMID 1339353
Disruption of the BCL11B gene through inv(14)(q11
Przybylski GK, Dik WA, Wanzeck J, Grabarczyk P, Majunke S, Martin-Subero JI, Siebert R, Dölken G, Ludwig WD, Verhaaf B, van Dongen JJ, Schmidt CA, Langerak AW
2q32 31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL
PMID 15668700
Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
Akasaka T, Balasas T, Russell LJ, Sugimoto KJ, Majid A, Walewska R, Karran EL, Brown DG, Cain K, Harder L, Gesk S, Martin-Subero JI, Atherton MG, Brüggemann M, Calasanz MJ, Davies T, Haas OA, Hagemeijer A, Kempski H, Lessard M, Lillington DM, Moore S, Nguyen-Khac F, Radford-Weiss I, Schoch C, Struski S, Talley P, Welham MJ, Worley H, Strefford JC, Harrison CJ, Siebert R, Dyer MJ
Blood 2007 Apr 15;109(8):3451-61
PMID 17170124
A chromosome 14 inversion in a T-cell lymphoma is caused by site-specific recombination between immunoglobulin and T-cell receptor loci
Denny CT, Yoshikai Y, Mak TW, Smith SD, Hollis GF, Kirsch IR
Nature 1986 Apr 10-16;320(6062):549-51
PMID 3008004
Common mechanism of chromosome inversion in B- and T-cell tumors: relevance to lymphoid development
Denny CT, Hollis GF, Hecht F, Morgan R, Link MP, Smith SD, Kirsch IR
Science 1986 Oct 10;234(4773):197-200
PMID 3092355
Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors
Baer R, Chen KC, Smith SD, Rabbitts TH
Cell 1985 Dec;43(3 Pt 2):705-13
PMID 3935328
Concurrent presence of inv(14)(q11q32) and t(4;11)(q21;q23) in pre-B acute lymphoblastic leukemia
Chervinsky DS, Grossi M, Kakati S, Block AW, Aplan PD
Genes Chromosomes Cancer 1995 Mar;12(3):229-36
PMID 7536464
Chromosome walking on the TCL1 locus involved in T-cell neoplasia
Virgilio L, Isobe M, Narducci MG, Carotenuto P, Camerini B, Kurosawa N, Abbas-ar-Rushdi, Croce CM, Russo G
Proc Natl Acad Sci U S A 1993 Oct 15;90(20):9275-9
PMID 8415691
Tissue microarray-based screening for chromosomal breakpoints affecting the T-cell receptor gene loci in mature T-cell lymphomas
Leich E, Haralambieva E, Zettl A, Chott A, Rüdiger T, Höller S, Müller-Hermelink HK, Ott G, Rosenwald A
J Pathol 2007 Sep;213(1):99-105
PMID 17582237
Human T-cell tumours containing chromosome 14 inversion or translocation with breakpoints proximal to immunoglobulin joining regions at 14q32
Mengle-Gaw L, Willard HF, Smith CI, Hammarström L, Fischer P, Sherrington P, Lucas G, Thompson PW, Baer R, Rabbitts TH
EMBO J 1987 Aug;6(8):2273-80
PMID 3117531
Juxtaposition of the T-cell receptor alpha-chain locus (14q11) and a region (14q32) of potential importance in leukemogenesis by a 14;14 translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia
Davey MP, Bertness V, Nakahara K, Johnson JP, McBride OW, Waldmann TA, Kirsch IR
Proc Natl Acad Sci U S A 1988 Dec;85(23):9287-91
PMID 3194425
Identification of the TCL1 gene involved in T-cell malignancies
Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G
Proc Natl Acad Sci U S A 1994 Dec 20;91(26):12530-4
PMID 7809072

Translocations implicated (Data extracted from papers in the Atlas)

 inv(14)(q11q32):t(14;14)(q11;q32) IGH/TRA

External links

IGH (14q32.33) TRA (10q26.13)

Mitelman databaseinv(14)(q11q32):t(14;14)(q11;q32) [Case List]    inv(14)(q11q32):t(14;14)(q11;q32) [Transloc-MCList] IGH/TRA [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Jan 10 17:22:57 CET 2018

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