t(14;16)(q32;q24) IGH/CBFA2T3

Identity

ICD-Topo	C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id	1622
Note	Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease

Burkitt lymphoma/leukemia|Chronic lymphocytic leukemia|Diffuse large B-cell lymphoma

Genes involved and Proteins

Gene Name	IGH
Location	14q32.33

Gene Name	CBFA2T3
Location	16q24.3

Bibliography

The CBFA2T3/ACSF3 locus is recurrently involved in IGH chromosomal translocation t(14;16)(q32;q24) in pediatric B-cell lymphoma with germinal center phenotype

Salaverria I, Akasaka T, Gesk S, Szczepanowski M, Burkhardt B, Harder L, Damm-Welk C, Oschlies I, Klapper W, Dyer MJ, Siebert R

Genes Chromosomes Cancer 2012 Apr;51(4):338-43

PMID 22420028

Non-coding recurrent mutations in chronic lymphocytic leukaemia

Puente XS, Beà S, Valdés-Mas R, Villamor N, Gutiérrez-Abril J, Martín-Subero JI, Munar M, Rubio-Pérez C, Jares P, Aymerich M, Baumann T, Beekman R, Belver L, Carrio A, Castellano G, Clot G, Colado E, Colomer D, Costa D, Delgado J, Enjuanes A, Estivill X, Ferrando AA, Gelpí JL, González B, González S, González M, Gut M, Hernández-Rivas JM, López-Guerra M, Martín-García D, Navarro A, Nicolás P, Orozco M, Payer ÁR, Pinyol M, Pisano DG, Puente DA, Queirós AC, Quesada V, Romeo-Casabona CM, Royo C, Royo R, Rozman M, Russiñol N, Salaverría I, Stamatopoulos K, Stunnenberg HG, Tamborero D, Terol MJ, Valencia A, López-Bigas N, Torrents D, Gut I, López-Guillermo A, López-Otín C, Campo E

Nature 2015 Oct 22;526(7574):519-24

PMID 26200345

Translocations implicated (Data extracted from papers in the Atlas)

	t(14;16)(q32;q24) IGH/CBFA2T3

External links

IGH (14q32.33) CBFA2T3 (16q24.3)

Mitelman database	t(14;16)(q32;q24) [Case List]    t(14;16)(q32;q24) [Transloc-MCList] IGH/CBFA2T3 [Fusion-MCList]
COSMIC	Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)	[select an item]

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
All articles	automatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Nov 28 16:23:53 CET 2018

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