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t(14;16)(q32;q24) IGH/CBFA2T3

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 1622
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Burkitt lymphoma/leukemia|Chronic lymphocytic leukemia|Diffuse large B-cell lymphoma

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameCBFA2T3
Location 16q24.3

Bibliography

The CBFA2T3/ACSF3 locus is recurrently involved in IGH chromosomal translocation t(14;16)(q32;q24) in pediatric B-cell lymphoma with germinal center phenotype
Salaverria I, Akasaka T, Gesk S, Szczepanowski M, Burkhardt B, Harder L, Damm-Welk C, Oschlies I, Klapper W, Dyer MJ, Siebert R
Genes Chromosomes Cancer 2012 Apr;51(4):338-43
PMID 22420028
 
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Puente XS, Beà S, Valdés-Mas R, Villamor N, Gutiérrez-Abril J, Martín-Subero JI, Munar M, Rubio-Pérez C, Jares P, Aymerich M, Baumann T, Beekman R, Belver L, Carrio A, Castellano G, Clot G, Colado E, Colomer D, Costa D, Delgado J, Enjuanes A, Estivill X, Ferrando AA, Gelpí JL, González B, González S, González M, Gut M, Hernández-Rivas JM, López-Guerra M, Martín-García D, Navarro A, Nicolás P, Orozco M, Payer ÁR, Pinyol M, Pisano DG, Puente DA, Queirós AC, Quesada V, Romeo-Casabona CM, Royo C, Royo R, Rozman M, Russiñol N, Salaverría I, Stamatopoulos K, Stunnenberg HG, Tamborero D, Terol MJ, Valencia A, López-Bigas N, Torrents D, Gut I, López-Guillermo A, López-Otín C, Campo E
Nature 2015 Oct 22;526(7574):519-24
PMID 26200345
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(14;16)(q32;q24) IGH/CBFA2T3

External links

IGH (14q32.33) CBFA2T3 (16q24.3)

Mitelman databaset(14;16)(q32;q24) [Case List]    t(14;16)(q32;q24) [Transloc-MCList] IGH/CBFA2T3 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
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indexed on : Mon Jul 9 10:15:57 CEST 2018


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