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t(14;18)(q32;q21) IGH/BCL2

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 1075
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Acute myeloid leukemia, NOS|B-prolymphocytic leukemia|Burkitt lymphoma/leukemia|Chronic lymphocytic leukemia|Dendritic cell neoplasm|Diffuse large B-cell lymphoma|Follicular lymphoma|Histiocytic sarcoma/malignant histiocytosis|Hodgkin disease, NOS|Hodgkin disease, lymphocyte predominance|Hodgkin disease, mixed cellularity|Hodgkin disease, nodular sclerosis|Mature B-cell neoplasm, NOS|Nonneoplastic hematologic disorder/lesion

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameBCL2
Location 18q21.33

Bibliography

The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile
Huang JZ, Sanger WG, Greiner TC, Staudt LM, Weisenburger DD, Pickering DL, Lynch JC, Armitage JO, Warnke RA, Alizadeh AA, Lossos IS, Levy R, Chan WC
Blood 2002 Apr 1;99(7):2285-90
PMID 11895757
 
Immunohistochemical expression of CD10 and t(14;18) chromosomal translocation may be indicators of follicle centre cell origin in nodal diffuse large B-cell lymphoma
McCluggage WG, Catherwood M, Alexander HD, McBride HA, Smith ME, Morris TC
Histopathology 2002 Nov;41(5):414-20
PMID 12405909
 
Is t(14;18)(q32;q21) a constant finding in follicular lymphoma? An interphase FISH study on 63 patients
Godon A, Moreau A, Talmant P, Baranger-Papot L, Geneviève F, Milpied N, Zandecki M, Avet-Loiseau H
Leukemia 2003 Jan;17(1):255-9
PMID 12529690
 
The t(14;18) is associated with germinal center-derived diffuse large B-cell lymphoma and is a strong predictor of outcome
Barrans SL, Evans PA, O'Connor SJ, Kendall SJ, Owen RG, Haynes AP, Morgan GJ, Jack AS
Clin Cancer Res 2003 Jun;9(6):2133-9
PMID 12796378
 
BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma
Iqbal J, Sanger WG, Horsman DE, Rosenwald A, Pickering DL, Dave B, Dave S, Xiao L, Cao K, Zhu Q, Sherman S, Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Ott G, Müller-Hermelink HK, Delabie J, Braziel RM, Jaffe ES, Campo E, Lynch JC, Connors JM, Vose JM, Armitage JO, Grogan TM, Staudt LM, Chan WC
Am J Pathol 2004 Jul;165(1):159-66
PMID 15215171
 
Trisomy 22 in acute myeloid leukemia: a marker for myeloid leukemia with monocytic features and cytogenetically cryptic inversion 16
Wong KF, Kwong YL
Cancer Genet Cytogenet 1999 Mar;109(2):131-3
PMID 10087946
 
The t(14;18) in diffuse large B-cell lymphoma: correlation with germinal center-associated markers and clinical features
Xu Y, McKenna RW, Doolittle JE, Hladik CL, Kroft SH
Appl Immunohistochem Mol Morphol 2005 Jun;13(2):116-23
PMID 15894922
 
The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement
Le Gouill S, Talmant P, Touzeau C, Moreau A, Garand R, Juge-Morineau N, Gaillard F, Gastinne T, Milpied N, Moreau P, Harousseau JL, Avet-Loiseau H
Haematologica 2007 Oct;92(10):1335-42
PMID 18024371
 
Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations
Niitsu N, Okamoto M, Miura I, Hirano M
Leukemia 2009 Apr;23(4):777-83
PMID 19151788
 
Prognostic value of the t(14;18)(q32;q21) in patients with diffuse large B-cell lymphoma
Abdel-Ghaffar H, El-Aziz SA, Shahin D, Degheidy H, Selim T, Elsobky E, Attwan N, Al-Tonbary YA
Cancer Invest 2010 May;28(4):376-80
PMID 19905895
 
Translocation t(14;18) in B cell lymphomas as a cause for defective immunoglobulin production
de Jong D, Voetdijk BM, Van Ommen GJ, Kluin-Nelemans JC, Beverstock GC, Kluin PM
J Exp Med 1989 Mar 1;169(3):613-24
PMID 2538543
 
MYC cytogenetic status correlates with expression and has prognostic significance in patients with MYC/BCL2 protein double-positive diffuse large B-cell lymphoma
Wang XJ, Medeiros LJ, Lin P, Yin CC, Hu S, Thompson MA, Li S
Am J Surg Pathol 2015 Sep;39(9):1250-8
PMID 25828389
 
Is t(14;18)(q32;q21) a constant finding in follicular lymphoma? An interphase FISH study on 63 patients
Godon A, Moreau A, Talmant P, Baranger-Papot L, Geneviève F, Milpied N, Zandecki M, Avet-Loiseau H
Leukemia 2003 Jan;17(1):255-9
PMID 12529690
 
Incidence and clinical significance of bcl-2/IgH rearrangements in follicular lymphoma
Montoto S, López-Guillermo A, Colomer D, Esteve J, Bosch F, Ferrer A, Villamor N, Moreno C, Campo E, Montserrat E
Leuk Lymphoma 2003 Jan;44(1):71-6
PMID 12691144
 
Low-grade follicular lymphoma with t(14;18) presents a homogeneous disease entity otherwise the rest comprises minor groups of heterogeneous disease entities with Bcl2 amplification, Bcl6 translocation or other gene aberrances
Guo Y, Karube K, Kawano R, Yamaguchi T, Suzumiya J, Huang GS, Ohshima K
Leukemia 2005 Jun;19(6):1058-63
PMID 15815725
 
''Minor'' BCL2 breakpoints in follicular lymphoma: frequency and correlation with grade and disease presentation in 236 cases
Weinberg OK, Ai WZ, Mariappan MR, Shum C, Levy R, Arber DA
J Mol Diagn 2007 Sep;9(4):530-7
PMID 17652637
 
Trisomy 22 in acute myeloid leukemia: a marker for myeloid leukemia with monocytic features and cytogenetically cryptic inversion 16
Wong KF, Kwong YL
Cancer Genet Cytogenet 1999 Mar;109(2):131-3
PMID 10087946
 
Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations
Leich E, Salaverria I, Bea S, Zettl A, Wright G, Moreno V, Gascoyne RD, Chan WC, Braziel RM, Rimsza LM, Weisenburger DD, Delabie J, Jaffe ES, Lister A, Fitzgibbon J, Staudt LM, Hartmann EM, Mueller-Hermelink HK, Campo E, Ott G, Rosenwald A
Blood 2009 Jul 23;114(4):826-34
PMID 19471018
 
Involvement of the bcl-2 gene in human follicular lymphoma
Tsujimoto Y, Cossman J, Jaffe E, Croce CM
Science 1985 Jun 21;228(4706):1440-3
PMID 3874430
 
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM
Science 1984 Nov 30;226(4678):1097-9
PMID 6093263
 
Clinical relevance of bcl-2(MBR)/J(H) rearrangement detected by polymerase chain reaction in the peripheral blood of patients with follicular lymphoma
Bertoni F, Bosshard G, Roggero E, Ceresa E, Cavalli F, Zucca E
Br J Cancer 1997;76(1):36-9
PMID 9218729
 
t(14;18) and bcl-2 gene rearrangement in a B-chronic lymphocytic leukaemia
Jonveaux P, Hillion J, Bennaceur AL, d'Agay MF, Brice P, Daniel MT, Sigaux F, Berger R
Br J Haematol 1992 Aug;81(4):620-1
PMID 1390255
 
Translocation t(14;18) is not associated with inferior outcome in chronic lymphocytic leukemia
Put N, Meeus P, Chatelain B, Rack K, Boeckx N, Nollet F, Graux C, Van Den Neste E, Janssens A, Madoe V, Van Hoof A, Bilhou-Nabera C, Wlodarska I, Vandenberghe P, Michaux L
Leukemia 2009 Jun;23(6):1201-4
PMID 19295547
 
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Puente XS, Beà S, Valdés-Mas R, Villamor N, Gutiérrez-Abril J, Martín-Subero JI, Munar M, Rubio-Pérez C, Jares P, Aymerich M, Baumann T, Beekman R, Belver L, Carrio A, Castellano G, Clot G, Colado E, Colomer D, Costa D, Delgado J, Enjuanes A, Estivill X, Ferrando AA, Gelpí JL, González B, González S, González M, Gut M, Hernández-Rivas JM, López-Guerra M, Martín-García D, Navarro A, Nicolás P, Orozco M, Payer ÁR, Pinyol M, Pisano DG, Puente DA, Queirós AC, Quesada V, Romeo-Casabona CM, Royo C, Royo R, Rozman M, Russiñol N, Salaverría I, Stamatopoulos K, Stunnenberg HG, Tamborero D, Terol MJ, Valencia A, López-Bigas N, Torrents D, Gut I, López-Guillermo A, López-Otín C, Campo E
Nature 2015 Oct 22;526(7574):519-24
PMID 26200345
 
Detection of bcl rearrangements in B-CLL by fluorescence in situ hybridization
Amiel A, Lishner M, Lalkin A, Gaber E, Manor Y, Fejgin M, Yarkoni S, Ravid M
Cancer Genet Cytogenet 1994 Apr;73(2):165-8
PMID 8174093
 
Expression of the bcl-2 oncogene product and chromosomal translocation t(14;18) in Hodgkin's disease
Lorenzen J, Hansmann ML, Pezzella F, Hesse C, Kneba M, Gatter KC, Fischer R
Hum Pathol 1992 Nov;23(11):1205-9
PMID 1427749
 
Expression of the bcl-2 oncogene product and chromosomal translocation t(14;18) in Hodgkin's disease
Lorenzen J, Hansmann ML, Pezzella F, Hesse C, Kneba M, Gatter KC, Fischer R
Hum Pathol 1992 Nov;23(11):1205-9
PMID 1427749
 
Single-cell analysis of the t(14;18)(q32;q21) chromosomal translocation in Hodgkin's disease demonstrates the absence of this translocation in neoplastic Hodgkin and Reed-Sternberg cells
Gravel S, Delsol G, Al Saati T
Blood 1998 Apr 15;91(8):2866-74
PMID 9531597
 
Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis
Kanungo A, Medeiros LJ, Abruzzo LV, Lin P
Mod Pathol 2006 Jan;19(1):25-33
PMID 16258503
 
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma
Snuderl M, Kolman OK, Chen YB, Hsu JJ, Ackerman AM, Dal Cin P, Ferry JA, Harris NL, Hasserjian RP, Zukerberg LR, Abramson JS, Hochberg EP, Lee H, Lee AI, Toomey CE, Sohani AR
Am J Surg Pathol 2010 Mar;34(3):327-40
PMID 20118770
 
B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome
Li S, Lin P, Fayad LE, Lennon PA, Miranda RN, Yin CC, Lin E, Medeiros LJ
Mod Pathol 2012 Jan;25(1):145-56
PMID 22002575
 
Oncogenic potential of bcl-2 demonstrated by gene transfer
Reed JC, Cuddy M, Slabiak T, Croce CM, Nowell PC
Nature 1988 Nov 17;336(6196):259-61
PMID 2848196
 
The reciprocal partners of both the t(14; 18) and the t(11; 14) translocations involved in B-cell neoplasms are rearranged by the same mechanism
Tsujimoto Y, Louie E, Bashir MM, Croce CM
Oncogene 1988 Apr;2(4):347-51
PMID 3129686
 
Translocation (14;18)(q32;q21) in acute lymphoblastic leukemia: a study of 12 cases and review of the literature
D'Achille P, Seymour JF, Campbell LJ
Cancer Genet Cytogenet 2006 Nov;171(1):52-6
PMID 17074591
 
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
Tsujimoto Y, Gorham J, Cossman J, Jaffe E, Croce CM
Science 1985 Sep 27;229(4720):1390-3
PMID 3929382
 
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM
Science 1984 Nov 30;226(4678):1097-9
PMID 6093263
 
De novo acute B-cell leukemia with translocation t(14;18): an entity with a poor prognosis
Kramer MH, Raghoebier S, Beverstock GC, de Jong D, Kluin PM, Kluin-Nelemans JC
Leukemia 1991 Jun;5(6):473-8
PMID 1711639
 
Translocation (14; 18) and (8; 22) in three patients with acute leukemia/lymphoma following centrocytic/centroblastic non-Hodgkin's lymphoma
Fiedler W, Weh HJ, Zeller W, Fonatsch C, Hillion J, Larsen C, Wörmann B, Hossfeld DK
Ann Hematol 1991 Nov;63(5):282-7
PMID 1958753
 
Translocations t(14;18) and t(8;14) with rearranged bcl-2 and c-myc in a case presenting as B-ALL (L3)
Brito-Babapulle V, Crawford A, Khokhar T, Laffan M, Matutes E, Fairhead S, Catovsky D
Leukemia 1991 Jan;5(1):83-7
PMID 1999960
 
Establishment and characterization of acute B-cell lymphocytic leukemia cell line showing (8;14) and (14;18) chromosome translocation
Matsuzaki H, Hata H, Asou N, Suzushima H, Akahoshi Y, Yoshida M, Nagakura S, Ishii T, Sanada I, Takatsuki K
Acta Haematol 1990;84(3):156-61
PMID 2123067
 
Clonal cytogenetic abnormalities and BCL2 rearrangement in interdigitating dendritic cell sarcoma
Nayer H, Murphy KM, Hawkins AL, Long PP, Gillison M, Borowitz M, Griffin CA
Leuk Lymphoma 2006 Dec;47(12):2651-4
PMID 17169812
 
BCL2 and BCL3 are recurrent translocation partners of the IGH locus
Szymanowska N, Klapper W, Gesk S, Küppers R, Martín-Subero JI, Siebert R
Cancer Genet Cytogenet 2008 Oct 15;186(2):110-4
PMID 18940474
 
Aggressive sporadic histiocytic sarcoma with immunoglobulin heavy chain gene rearrangement and t(14;18)
Hayase E, Kurosawa M, Yonezumi M, Suzuki S, Suzuki H
Int J Hematol 2010 Nov;92(4):659-63
PMID 20976632
 
Two cases of histiocytic sarcoma with BCL2 translocations and occult or subsequent follicular lymphoma
Fernandez-Pol S, Bangs CD, Cherry A, Arber DA, Gratzinger D
Hum Pathol 2016 Sep;55:39-43
PMID 27134111
 
t(14;18) Translocation: A predictive blood biomarker for follicular lymphoma
Roulland S, Kelly RS, Morgado E, Sungalee S, Solal-Celigny P, Colombat P, Jouve N, Palli D, Pala V, Tumino R, Panico S, Sacerdote C, Quirós JR, Gonzáles CA, Sánchez MJ, Dorronsoro M, Navarro C, Barricarte A, Tjønneland A, Olsen A, Overvad K, Canzian F, Kaaks R, Boeing H, Drogan D, Nieters A, Clavel-Chapelon F, Trichopoulou A, Trichopoulos D, Lagiou P, Bueno-de-Mesquita HB, Peeters PH, Vermeulen R, Hallmans G, Melin B, Borgquist S, Carlson J, Lund E, Weiderpass E, Khaw KT, Wareham N, Key TJ, Travis RC, Ferrari P, Romieu I, Riboli E, Salles G, Vineis P, Nadel B
J Clin Oncol 2014 May 1;32(13):1347-55
PMID 24687831
 
Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals
Limpens J, Stad R, Vos C, de Vlaam C, de Jong D, van Ommen GJ, Schuuring E, Kluin PM
Blood 1995 May 1;85(9):2528-36
PMID 7727781
 
BCL2 translocation frequency rises with age in humans
Liu Y, Hernandez AM, Shibata D, Cortopassi GA
Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8910-4
PMID 8090743
 
Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia
Gauwerky CE, Huebner K, Isobe M, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1989 Nov;86(22):8867-71
PMID 2682663
 
Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia
Brown FC, Cifani P, Drill E, He J, Still E, Zhong S, Balasubramanian S, Pavlick D, Yilmazel B, Knapp KM, Alonzo TA, Meshinchi S, Stone RM, Kornblau SM, Marcucci G, Gamis AS, Byrd JC, Gonen M, Levine RL, Kentsis A
Br J Haematol 2017 Jan;176(1):86-91
PMID 27766616
 


Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

Genes MYBL1 SERPINB5

Translocations implicated (Data extracted from papers in the Atlas)

 t(14;18)(q32;q21) IGH/BCL2

External links

IGH (14q32.33) BCL2 (18q21.33)

Mitelman databaset(14;18)(q32;q21) [Case List]    t(14;18)(q32;q21) [Transloc-MCList] IGH/BCL2 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 5 17:04:12 CEST 2018


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