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t(14;19)(q32;q13) IGH/BCL3

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3489
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Bilineage or biphenotypic leukemia|Chronic lymphocytic leukemia|Diffuse large B-cell lymphoma|Follicular lymphoma|Hodgkin disease, NOS|Mature B-cell neoplasm, NOS|Nodal marginal zone B-cell lymphoma|Splenic marginal zone B-cell lymphoma

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameBCL3
Location 19q13.32


Interphase detection of immunoglobulin heavy chain gene translocations with specific oncogene loci in 173 patients with B-cell lymphoma
Tamura A, Miura I, Iida S, Yokota S, Horiike S, Nishida K, Fujii H, Nakamura S, Seto M, Ueda R, Taniwaki M
Cancer Genet Cytogenet 2001 Aug;129(1):1-9
PMID 11520558
Bcl-3/IgH translocation (14;19)(q32;q13) in non-Hodgkin's lymphomas
Au WY, Horsman DE, Ohno H, Klasa RJ, Gascoyne RD
Leuk Lymphoma 2002 Apr;43(4):813-6
PMID 12153169
Splenic small B-cell lymphoma with IGH/BCL3 translocation
Soma LA, Gollin SM, Remstein ED, Ketterling RP, Flynn HC, Rajasenan KK, Swerdlow SH
Hum Pathol 2006 Feb;37(2):218-30
PMID 16426923
B-cell non-Hodgkin's lymphoma: evidence for the t (14;18) translocation in all hematopoietic cell lineages
Yarkoni S, Lishner M, Tangi I, Nagler A, Lorberboum-Galski H
J Natl Cancer Inst 1996 Jul 17;88(14):973-9
PMID 8667428
A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation
Martín-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F, Calasanz MJ, De Wolf-Peeters C, Dyer MJ, Felman P, Gardiner A, Gascoyne RD, Gesk S, Harder L, Horsman DE, Kneba M, Küppers R, Majid A, Parry-Jones N, Ritgen M, Salido M, Solé F, Thiel G, Wacker HH, Oscier D, Wlodarska I, Siebert R
Leukemia 2007 Jul;21(7):1532-44
PMID 17495977
BCL2 and BCL3 are recurrent translocation partners of the IGH locus
Szymanowska N, Klapper W, Gesk S, Küppers R, Martín-Subero JI, Siebert R
Cancer Genet Cytogenet 2008 Oct 15;186(2):110-4
PMID 18940474
Translocation (14;19) in acute biphenotypic leukemia
Carter R, Dubé I, McKeithan T, Carstairs K, DeHarven E, Bailey D, Scott JG
Cancer Genet Cytogenet 1991 May;53(1):67-73
PMID 1903671
Identification of a transcriptional unit adjacent to the breakpoint in the 14;19 translocation of chronic lymphocytic leukemia
McKeithan TW, Ohno H, Diaz MO
Genes Chromosomes Cancer 1990 Jan;1(3):247-55
PMID 2083219
Cloning and sequencing of a t(14;19) breakpoint that involves the C mu switch region
Crossen PE, Kennedy MA, Heaton DC, Morrison MJ
Genes Chromosomes Cancer 1993 Sep;8(1):60-2
PMID 7691160
Molecular characterization of the t(14;19)(q32;q13) translocation in chronic lymphocytic leukemia
Ohno H, Doi S, Yabumoto K, Fukuhara S, McKeithan TW
Leukemia 1993 Dec;7(12):2057-63
PMID 8255106

Translocations implicated (Data extracted from papers in the Atlas)

 t(14;19)(q32;q13) IGH/BCL3

External links

IGH (14q32.33) BCL3 (19q13.32)

Mitelman databaset(14;19)(q32;q13) [Case List]    t(14;19)(q32;q13) [Transloc-MCList] IGH/BCL3 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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