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t(15;21)(q21;q22) RUNX1/TCF12

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3181
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute myeloblastic leukemia with maturation (FAB type M2)|Acute myeloid leukemia, NOS|Chronic myelomonocytic leukemia|Chronic myeloproliferative disorder, NOS

Genes involved and Proteins

Gene NameRUNX1
Gene NameTCF12
Location 15q21.3

Bibliography

t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid disorders
L'Abbate A, Tolomeo D, De Astis F, Lonoce A, Lo Cunsolo C, Mühlematter D, Schoumans J, Vandenberghe P, Van Hoof A, Palumbo O, Carella M, Mazza T, Storlazzi CT
Mol Cancer 2015 Dec 16;14:211
PMID 26671595
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(15;21)(q21;q22) RUNX1/TCF12

External links

RUNX1 () TCF12 (15q21.3)

Mitelman databaset(15;21)(q21;q22) [Case List]    t(15;21)(q21;q22) [Transloc-MCList] RUNX1/TCF12 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
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indexed on : Mon May 14 13:45:39 CEST 2018


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