Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

Isolated tetrasomy 8 in AML, MDS and MPD

Written2008-09Olivier Theisen, Jean-Luc Lai, Olivier Nibourel, Catherine Roche-Lestienne
Laboratoire de genetique medicale, hopital Jeanne de Flandre, CHRU de Lille, France (OT, JLL, CRL); Laboratoire d'hematologie, Centre de Biologie et Pathologie, CHRU de Lille, France (ON)

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1517
Note Isolated tetrasomy 8 is relatively rare compared to trisomy 8. A review of literature revealed only 29 cases of solely tetrasomy 8 in hematologic malignancies. Except for the implication of MLL in AML cases, no additional molecular abnormalities have been explored.
 
  GTG-banding karyotype with isolated tetrasomy 8 in AML-M5.

Clinics and Pathology

Disease Acute myeloid leukemia (AML)
Phenotype / cell stem origin FAB subtypes: M0 AML (2 cases) M1 AML (1 case) M2 AML (3 cases) M4 AML (3 cases) M5 AML (11 cases out 20).
Epidemiology Median age 56 years (range: 17-82 years); sex ratio: 13M/7F.
Clinics Tetrasomy 8 has been observed in de novo malignant hemopathies as well as in leukaemia with prior history of haematological disorder (4 cases of myelodisplastic syndrome: 2 RA and 2 RAEB), exposure to radiotherapy or treatment with cytotoxic chemotherapy (1 case of each).
Prognosis Median survival: 15 months.

Disease Myelodysplastic syndrome (MDS)
Phenotype / cell stem origin FAB subtypes: refractory anemia (RA) (1 case), refractory anemia with excess of blasts (RAEB) (1 case), refractory anemia with ringed sideroblasts (RARS) (1 case), chronic myelomonocytic leukemia (CMML) (2 cases) and MF (1 case).
Epidemiology Median age: 68 years (range: 46-91 years); sex ratio: 4M/2F.
Prognosis Median survival: 5.5 months.

Disease Myeloproliferative disorder (MPD)
Phenotype / cell stem origin Subtypes: polycytemia vera (PV) (1 case) and myelofibrosis (MMM) (2 cases).
Epidemiology Median age: 36 years (range 30-51 years); sex ratio: 0M/3F.
Prognosis Median survival: 36 months.

Cytogenetics

 

Bibliography

Polysomy 8 defines a clinico-cytogenetic entity representing a subset of myeloid hematologic malignancies associated with a poor prognosis: report on a cohort of 12 patients and review of 105 published cases.
Beyer V, Muhlematter D, Parlier V, Cabrol C, Bougeon-Mamin S, Solenthaler M, Tobler A, Pugin P, Gregor M, Hitz F, Hess U, Chapuis B, Laurencet F, Schanz U, Schmidt PM, van Melle G, Jotterand M.
Cancer Genet Cytogenet. 2005 Jul 15;160(2):97-119.
PMID 15993266
 
Tetrasomy of chromosome 8 in a patient with acute myeloid leukemia.
Cull GM, Howe DJ, Stack-Dunne M, Phillips MJ, Johnson SA.
Leuk Lymphoma. 1995 Oct;19(3-4):355-8.
PMID 8535231
 
Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia.
Ferro MT, Vazquez-Mazariego Y, Ramiro S, Santiago MF, Garcia-Sagredo JM, Nunez R, Hernandez JM, San Roman C.
Cancer Genet Cytogenet. 2000 Jul 15;120(2):163-5.
PMID 10942810
 
A new case of isolated tetrasomy of chromosome 8 in a patient with therapy-related myelodysplastic syndrome: confirmation by chromosome painting in metaphase and interphase nuclei.
Flactif M, Lai JL, Deminatti MM.
Cancer Genet Cytogenet. 1993 Feb;65(2):175-6.
PMID 8453606
 
Tetrasomy of chromosome 8: an interesting and rare cytogenetic phenomenon in acute nonlymphocytic leukemia.
Jani Sait SN, Raza A, Sandberg AA.
Cancer Genet Cytogenet. 1987 Aug;27(2):269-71.
PMID 3594416
 
Clonal evolution from trisomy into tetrasomy of chromosome 8 associated with the development of acute myeloid leukemia from myelodysplastic syndrome.
Kameoka J, Funato T, Obara Y, Kadowaki I, Yokoyama H, Kimura T, Tomiya Y, Yamada M, Ishikawa I, Takagawa M, Sasaki O, Kimura J, Harigae H, Miura I, Meguro K, Kaku M, Sasaki T.
Cancer Genet Cytogenet. 2001 Jan 15;124(2):159-64.
PMID 11172910
 
Tetrasomy 8 in a patient with acute monoblastic leukemia.
Kim J, Park TS, Song J, Lee KA, Lee SG, Cheong JW, Choi JR.
Korean J Lab Med. 2008 Aug;28(4):262-6.
PMID 18728374
 
Prognostic impact of karyotype and immunologic phenotype in 125 adult patients with de novo AML.
Marosi C, Koller U, Koller-Weber E, Schwarzinger I, Schneider B, Jager U, Vahls P, Nowotny H, Pirc-Danoewinata H, Steger G, et al.
Cancer Genet Cytogenet. 1992 Jul 1;61(1):14-25.
PMID 1638477
 
Tetrasomy 8 in acute monoblastic leukemia (AML-M5a) with myelosarcomatosis of the skin.
Marosi C, Muhm M, Argyriou-Tirita A, Pehamberger H, Pirc-Danoewinata H, Geissler K, Locker G, Grois N, Haas OA.
Cancer Genet Cytogenet. 1993 Nov;71(1):50-4.
PMID 8275452
 
Fluorescent in situ hybridization in routinely processed bone marrow aspirate clot and core biopsy sections.
Miranda RN, Mark HF, Medeiros LJ.
Am J Pathol. 1994 Dec;145(6):1309-14.
PMID 7992836
 
Coexistence of tetrasomy 8 and trisomy 8 in a case with myeloid metaplasia with myelofibrosis.
Sole F, de Pablos JM, Woessner S, Perez MM, Jurado M, Espinet B, Grao P, Moratalla A, Esquivias J.
Cancer Genet Cytogenet. 1997 Apr;94(2):147-50.
PMID 9109946
 
Tetrasomy 8 as a clonal anomaly in myeloid neoplasias.
Trautmann U, Gramatzki M, Krauss M, Friz A, Liehr T, Gebhart E.
Cancer Genet Cytogenet. 1994 Feb;72(2):101-4.
PMID 8143266
 
A further case of acute nonlymphocytic leukemia with tetrasomy 8.
Wullich B, Koch B, Schwarz M, Lindemann U, Pfreundschuh M, Zang KD.
Cancer Genet Cytogenet. 1993 Sep;69(2):126-8.
PMID 8402549
 
Isolated tetrasomy 8 in minimally differentiated acute myeloid leukemia (AML-M0).
Xue Y, Guo Y, Zhou Y, Xie X, Zheng L, Shen M.
Leuk Lymphoma. 1999 May;33(5-6):581-5.
PMID 10342586
 
Tetrasomy 8 is associated with a major cellular proliferative advantage and a poor prognosis. two cases of myeloid hematologic disorders and review of the literature.
Yan J, Marceau D, Drouin R.
Cancer Genet Cytogenet. 2001 Feb;125(1):14-20.
PMID 11297762
 
Tetrasomy 8 in acute myelomonocytic leukemia developing after a gastric cancer operation.
Yoshida J, Nakata K, Oda E, Oda S, Ueyama T, Ambe K, Shiroozu A, Shikata I, Kishikawa H, Iino H.
Cancer Genet Cytogenet. 1991 Jul 1;54(1):27-31.
PMID 2065313
 

Citation

This paper should be referenced as such :
Theisen, O ; Lai, JL ; Nibourel, O ; Roche-Lestienne, C
Isolated tetrasomy 8 in AML, MDS, MPD
Atlas Genet Cytogenet Oncol Haematol. 2009;13(9):671-672.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/Tetra8ID1517.html


External links

arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9975/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9989/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaseIsolated tetrasomy 8 in AML, MDS and MPD
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:45:31 CET 2017


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.