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+7 or trisomy 7 (solely)

Written2012-03Wei Wang, Cyrus Manavi, Changlee Pang, Patrick Koty, Mark J Pettenati
Department of Pathology, Wake Forest Baptist Health, Medical Center Blvd, Winston-Salem, NC, 27157, USA (WW, CM, CP, PK, MJP); Pediatrics, Medical Genetics, Wake Forest Baptist Health, Medical Center Blvd, Winston-Salem, NC, 27157, USA (PK, MJP)

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ICD-Morpho 9837/3 T lymphoblastic leukaemia/lymphoma
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1581
Note Trisomy 7 is a common finding in benign and malignant solid tumors, in several non-neoplastic lesions (for example, osteoarthritis and rheumatoid arthritis), and in apparently normal tissues as well. Trisomy 7 is found in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), but very rarely as the sole karyotypic abnormality.
  Trisomy 7 Fluorescence in situ hybridization with the Vysis LSI D7S486 SpectrumOrange/CEP 7 SpectrumGreen probe (Abbott Molecular, US) showing 3 copies of chromosome 7 - Courtesy Adriana Zamecnikova.

Clinics and Pathology

Disease Acute myeloid leukemia (AML)
Epidemiology +7 as the sole anomaly is a rare chromosomal abnormality. Only four cases of AML with isolated trisomy 7 have been described in the literature. These cases show various FAB subtypes including M0, M5a, M1, and M4, and two cases of myelodysplastic syndrome (Hagemeijer et al., 1981; Leverger et al., 1988; Bernell et al., 1996; Taketani et al., 2003).
Clinics In the four reported cases of AML with trisomy 7, there is no clinical history, laboratory results, nor immunophenotypic studies available for analysis. The two cases of myelodysplastic syndrome with isolated trisomy 7 were a 77 year-old female patient diagnosed with myelodysplastic syndrome and a 75 year-old male patient with refractory anemia with excess blasts - 1 (RAEB-1) who later developed acute myeloid leukemia.
Prognosis Patients with trisomy 7 seem to have very poor prognosis with the survival time of five months and three months in AML cases. In the MDS cases one patient died three months after diagnosis. The second patient developed AML two months after the diagnosis of MDS and died four days after his AML was diagnosed.

Disease Acute lymphoblastic leukemia (ALL)
Epidemiology +7 is very rare as a sole chromosomal abnormality in ALL. Only three cases of ALL with isolated trisomy 7 have been previously described in the literature. Patient ages range from 8 months to 44 years old. No detailed clinical and pathological information is available for review (El-Rifai et al., 1997; Whitehead et al., 1998; Ameye et al., 2000).
Prognosis The prognosis of ALL with trisomy 7 is unknown, largely due to the rarity and lack of follow up of this entity.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


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AML1/RUNX1 mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies.
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Accumulation of methotrexate polyglutamates, ploidy and trisomies of both chromosomes 4 and 10 in lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group Study.
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This paper should be referenced as such :
Wang, W ; Manavi, C ; Pang, C ; Koty, P ; Pettenati, MJ
+7 or trisomy 7 (solely)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(9):674-675.
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External links

arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9837/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9989/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
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