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Y loss in leukemia

Written1999-01François Desangles
Laboratoire de Biologie, Hôpital du Val de Grâce, 75230 Paris, France
Updated2001-01Daniel L. Van Dyke
FACMG, Cytogenetics Laboratory, Mayo Clinic, USA

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Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1089
Note Loss of the Y chromosome from individual metaphases is common in metaphase cells from both PHA-stimulated lymphocytes and spontaneously dividing bone marrow cells. The frequency of Y loss is greater in older men, and the size of the 45,X,-Y cell population probably increases gradually with advancing age. (In females, a corollary loss of one X chromosome also occurs with advancing age.) This natural phenomenon challenges our ability to distinguish between a normal and a disease-associated 45,X,-Y clone.

Clinics and Pathology

Disease -Y is frenquently observed in myeloproliferative diseases (MPD), myelodysplasic syndromes (MDS), acute myeloid leukemias (AML), and can also be seen in lymphoproliferations
Epidemiology In CML with t(9;22) and in AML with a t(8;21), loss of the Y chromosome tends to occurs at a younger age than in the general population
Clinics
  • Partial or complete reappearance of the Y chromosome has been described in several cases of AML in remission. In most or all of these AML cases, the 45,X,-Y cell population represented 80-100% of pre-remission metaphases. These observations support the interpretation that the leukemia cell karyotype is 45,X,-Y.
  • In MDS, the proportion of -Y cells has been observed to increase, decrease, remain stable, or fluctuate up and down on follow-up studies.
  • In four cases of Hodgkin disease, simultaneous fluorescence immunophenotyping and FISH showed that the -Y cell population was probably independent of the Hodgkin disease in at least two of the patients. It is notable that the -Y cells represented fewer than 10-15% of the metaphase cells in all four cases.
  • Cytology no known association
    Prognosis In AML, a 45,X,-Y karyotype is believed to have an intermediate prognosis. In MDS, the prognosis appears to be neutral or favorable. There are insufficient data for MPD or lymphoproliferative disease

    Cytogenetics

    Cytogenetics Morphological
  • In PHA-stimulated lymphocyte karyotype studies of males, about 2% have one or more cells with loss of the Y chromosome. Cells with -Y are observed more often in males over age 55 than in younger males. In all age groups, the proportion of -Y cells is usually under 10%.
  • The pattern of Y loss is more striking in bone marrow aspirate karyotype studies. Here, clonal Y chromosome loss as a sole abnormality in the karyotype is a common finding. A 45,X,-Y karyotype is observed in about 6% of bone marrow karyotype studies from males, and it represents 15-20% of abnormal karyotypes.
  • The frequency of -Y cells increases with advancing age and is significantly greater in cases with MDS, MPD, AML, or lymphoproliferative disease than in subjects who have no evidence of disease. Subjects with no evidence of disease rarely exhibit more than 75% of cells with 45,X,-Y. Thus, if fewer than 75% of metaphase cells are -Y, the disease association is uncertain. However, if 75-100% of metaphase cells are -Y, the karyotype probably is disease-associated, even in older men.
  • Chromosome rearrangements involving the Y chromosome are rare in cancer and leukemia. Loss of the Y chromosome, in contrast, is a common secondary change in cancer cells and in a few leukemias (see below).
  • Additional anomalies In association with t(9;22) in CML and with t(8;21) in FAB-M2 AML, loss of the Y chromosome is generally considered a secondary event of no added clinical significance.

    Genes involved and Proteins

    Note genes involved, if any, are unknown

    To be noted

    It is not known whether the Y chromosome loss is the critical mutational event. Likewise, it is not known whether the Y chromosome loss is a secondary genetic change, or if the critical (submicroscopic) genetic change simply occurs by chance in a -Y cell. Speculatively, loss of the Y could provide a proliferative advantage simply because it tends to replicate late in S-phase. Its loss might therefore shorten the cell cycle slightly.

    Bibliography

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    Genes, chromosomes & cancer. 1992 ; 5 (1) : 83-88.
    PMID 1384666
     
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    Abe S, Golomb HM, Rowley JD, Mitelman F, Sandberg AA
    Cancer. 1980 ; 45 (1) : 84-90.
    PMID 6985828
     
    Loss of Y chromosome. An age-related event or a cytogenetic marker of a malignant clone?
    Abeliovich D, Yehuda O, Ben-Neriah S, Or R
    Cancer genetics and cytogenetics. 1994 ; 76 (1) : 70-71.
    PMID 8076356
     
    Y chromosome loss in leukemias.
    Berger R, Bernheim A
    Cancer Genet Cytogenet. 1979 ; 1 : 1-8.
     
    Loss of the Y chromosome in acute myelogenous leukemia: a report of 13 patients.
    Holmes RI, Keating MJ, Cork A, Trujillo JM, McCredie KB, Freireich EJ
    Cancer genetics and cytogenetics. 1985 ; 17 (3) : 269-278.
    PMID 3859363
     
    Y chromosome loss in chronic myeloid leukemia detected in both normal and malignant cells by interphase fluorescence in situ hybridization.
    Kirk JA, VanDevanter DR, Biberman J, Bryant EM
    Genes, chromosomes & cancer. 1994 ; 11 (3) : 141-145.
    PMID 7530482
     
    The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history.
    Nowinski GP, Van Dyke DL, Tilley BC, Jacobsen G, Babu VR, Worsham MJ, Wilson GN, Weiss L
    American journal of human genetics. 1990 ; 46 (6) : 1101-1111.
    PMID 2339703
     
    Age-associated aneuploidy: loss of Y chromosome from human bone marrow cells with aging.
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    PMID 4116908
     
    X and Y chromosome loss as sole abnormality in acute non-lymphocytic leukemia (AML)
    Riske CB, Morgan R, Ondreyco S, Sandberg AA
    Cancer genetics and cytogenetics. 1994 ; 72 (1) : 44-47.
    PMID 8111738
     
    Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study.
    Slovak ML, Kopecky KJ, Cassileth PA, Harrington DH, Theil KS, Mohamed A, Paietta E, Willman CL, Head DR, Rowe JM, Forman SJ, Appelbaum FR
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    Clarification of dubious karyotypes in Hodgkin's disease by simultaneous fluorescence immunophenotyping and interphase cytogenetics (FICTION).
    Weber-Matthiesen K, Deerberg J, Poetsch M, Grote W, Schlegelberger B
    Cytogenetics and cell genetics. 1995 ; 70 (3-4) : 243-245.
    PMID 7789181
     
    Clinical significance of Y chromosome loss in hematologic disease.
    Wiktor A, Rybicki BA, Piao ZS, Shurafa M, Barthel B, Maeda K, Van Dyke DL
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    PMID 10564581
     

    Citation

    This paper should be referenced as such :
    Van Dyke, DL
    Y loss in leukemia
    Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):56-57.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Anomalies/YlossID1089.html
    History of this paper:
    Desangles, F. -Y / Y loss in leukemia. Atlas Genet Cytogenet Oncol Haematol. 1999;3(2):80-81.
    http://documents.irevues.inist.fr/bitstream/handle/2042/37511/01-1999-YlossID1089.pdf


    Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

    Genes ABL1 BCR

    Translocations implicated (Data extracted from papers in the Atlas)

     del(Y)
     -Y

    External links

    Mitelman databasedel(Y) [Case List]    del(Y) [Association List] Mitelman database (CGAP - NCBI)
    Mitelman database-Y [Case List]    -Y [Association List] Mitelman database (CGAP - NCBI)
    arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
    arrayMapTopo ( C42) Morph ( 9975/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
    arrayMapTopo ( C42) Morph ( 9989/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
     
     
    Disease databaseY loss in leukemia
    REVIEW articlesautomatic search in PubMed
    Last year articlesautomatic search in PubMed
    All articlesautomatic search in PubMed


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