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del(13q) in ALL

Written2004-11David Betts
Department of Oncology, University Children's Hospital, Steinwiesstr. 75, CH-8032 Zò_rich, Switzerland

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9837/3 T lymphoblastic leukaemia/lymphoma
Atlas_Id 1188
Note Deletions of chromosome 13q are a non-random finding in a broad spectrum of haematological neoplasms, including B-cell chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM) and (AML)

Clinics and Pathology

Disease Acute lymphoblastic leukaemia (ALL)
Phenotype / cell stem origin No specific immunophenotype observed
Epidemiology A del(13q) chromosome is found in approximately 2% of cases in both adult and childhood disease at presentation. Up to 4% of cases may have some loss of 13q material, either through full monosomy or unbalanced rearrangements. Incidence of chromosome 13 deletions is higher at relapse.
Prognosis May confer an increased risk of treatment failure but to date has not been shown to be an independent prognostic indicator.

Cytogenetics

Cytogenetics Morphological Various breakpoints reported. The centromeric breakpoint is typically in the 13q12-14 region and telomeric between 13q21 and 13qter. Loss of all or part of 13q14 is common to almost all cases. Occurs as a sole event in approximately 10% of cases. There are also rare reports of translocations also leading to a partial 13q deletion. Monosomy 13 is also reported but occurs very rarely as a sole aberration. Under representation of chromosome 13 is often found in hypotriploid cases.
Additional anomalies Most cases with del(13q) will have additional aberrations, but there is no consistent picture and the events can include the typical non-random events in ALL.

Genes involved and Proteins

Note Critical region in 13q14 appears to lie telomeric to RB1.

Bibliography

Deletion of chromosomal region 13q14.3 in childhood acute lymphoblastic leukemia.
Cavé H, Avet-Loiseau H, Devaux I, Rondeau G, Boutard P, Lebrun E, Méchinaud F, Vilmer E, Grandchamp B
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2001 ; 15 (3) : 371-376.
PMID 11237059
 
Deletions in the 13q14 locus in adult lymphoblastic leukemia: rate of incidence and relevance.
Chung CY, Kantarjian H, Haidar M, Starostik P, Manshouri T, Gidel C, Freireich E, Keating M, Albitar M
Cancer. 2000 ; 88 (6) : 1359-1364.
PMID 10717617
 
Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia.
Heerema NA, Sather HN, Sensel MG, Lee MK, Hutchinson RJ, Nachman JB, Reaman GH, Lange BJ, Steinherz PG, Bostrom BC, Gaynon PS, Uckun FM
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2000 ; 18 (22) : 3837-3844.
PMID 11078497
 
Aberrations involving 13q12 approximately q14 are frequent secondary events in childhood acute lymphoblastic leukemia.
Kovacs BZ, Niggli FK, Betts DR
Cancer genetics and cytogenetics. 2004 ; 151 (2) : 157-161.
PMID 15172754
 
New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases.
Schneider NR, Carroll AJ, Shuster JJ, Pullen DJ, Link MP, Borowitz MJ, Camitta BM, Katz JA, Amylon MD
Blood. 2000 ; 96 (7) : 2543-2549.
PMID 11001909
 

Citation

This paper should be referenced as such :
Betts, D
del(13q) in ALL
Atlas Genet Cytogenet Oncol Haematol. 2005;9(1):23-23.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/del13qALLID1188.html


Translocations implicated (Data extracted from papers in the Atlas)

 del(13q) in ALL

External links

Mitelman databasedel(13q) [Case List]    del(13q) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9811/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9837/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databasedel(13q) in ALL
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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