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del(17p) in non-Hodgkin's lymphoma (NHL)

Written2000-12Antonio Cuneo, Gianluigi Castoldi
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

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Atlas_Id 2083
Note the 17p- chromosome is a secondary change in most cases of NHL
  del(17p)  Hybridization with the LSI p53/CEP17 and LSI p53 probes (Abbott molecular, US) showing 2 green and 2 red signals on normal metaphase (A) and only 1 red signal in metaphase and interphase cells with 17p deletion (B,C) – Courtesy Adriana Zamecnikova. Insert: del(17p) G- banding – Top: Courtesy Melanie Zenger and Claudia Haferlach: Bottom: – Courtesy Adriana Zamecnikova.

Clinics and Pathology

Disease virtually all histologic subsets of NHL may harbour a 17p- chromosome; there is variation in the reported incidence due to heterogeneity of histologic classification and to the different sensitivity of the detection methods
  • 10 to 15% of follicle centre cell lymphoma (FCCL) and mantle cell lymphomas (MCL) may carry a 17p- chromosome; minority of marginal zone B-cell lymphomas may be associated with 17p deletion
  • this anomaly is rarely found in T-cell NHL
  • Prognosis the 17p- chromosome was reported to predict for a poor prognosis in low grade lymphomas; any abnormality of chromosome 17 was also reported to negatively affect survival in lymphomas of all histologic grades


    Cytogenetics Morphological
  • the deleted segment may vary in size and many cases with sub-microscopic deletions involving the 17p13 band were reported by FISH; cases with unbalanced 17p translocations leading to 17p loss were also described; these cases may be associated with dicentric rearrangements
  • the 17p- is usually associated with transformation of a low-grade FCCL with t(14;18) into a high grade lymphoma; likewise, there is a higher incidence of 17p- in the blastoid variant of MCL with t(11,14) than in the typical form
  • Cytogenetics Molecular the deletion may be detected by G or R-banding; FISH using a 17p13/p53 probe is recommended, this technique being more sensitive than conventional cytogenetics

    Genes involved and Proteins

    Note the majority of cases with 17p- carry a p53 gene deletion, associated with mutation of the remaining allele; there may be a small fraction of cases with a more distal deletion involving an as yet unidentified locus


    Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants.
    Beá S, Ribas M, Hernández JM, Bosch F, Pinyol M, Hernández L, García JL, Flores T, González M, López-Guillermo A, Piris MA, Cardesa A, Montserrat E, Miró R, Campo E
    Blood. 1999 ; 93 (12) : 4365-4374.
    PMID 10361135
    Refractoriness to chemotherapy and poor survival related to abnormalities of chromosomes 17 and 7 in lymphoma.
    Cabanillas F, Pathak S, Grant G, Hagemeister FB, McLaughlin P, Swan F, Rodriguez MA, Trujillo J, Cork A, Butler JJ
    The American journal of medicine. 1989 ; 87 (2) : 167-172.
    PMID 2757057
    Translocations involving the short arm of chromosome 17 in chronic B-lymphoid disorders: frequent occurrence of dicentric rearrangements and possible association with adverse outcome.
    Callet-Bauchu E, Salles G, Gazzo S, Poncet C, Morel D, Pagès J, Coiffier B, Coeur P, Felman P
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1999 ; 13 (3) : 460-468.
    PMID 10086737
    Analysis of p53 gene deletions in patients with non-Hodgkin's lymphoma by dual-colour fluorescence in-situ hybridization.
    Clodi K, Younes A, Goodacre A, Roberts M, Palmer J, Younes M, Cabanillas F, Andreeff M
    British journal of haematology. 1997 ; 98 (4) : 913-921.
    PMID 9326189
    Molecular cytogenetic characterization of marginal zone B-cell lymphoma: correlation with clinicopathologic findings in 14 cases.
    Cuneo A, Bigoni R, Roberti MG, Milani R, Agostini P, Cavazzini F, Minotto C, De Angeli C, Bardi A, Tammiso E, Negrini M, Cavazzini P, Castoldi G
    Haematologica. 2001 ; 86 (1) : 64-70.
    PMID 11146573
    Identification of a commonly deleted region at 17p13.3 in leukemia and lymphoma associated with 17p abnormality.
    Sankar M, Tanaka K, Kumaravel TS, Arif M, Shintani T, Yagi S, Kyo T, Dohy H, Kamada N
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (4) : 510-516.
    PMID 9557609
    Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low-grade and high-grade lymphomas.
    Schlegelberger B, Himmler A, Gödde E, Grote W, Feller AC, Lennert K
    Blood. 1994 ; 83 (2) : 505-511.
    PMID 8286748
    Prognostic value of chromosomal abnormalities in follicular lymphoma.
    Tilly H, Rossi A, Stamatoullas A, Lenormand B, Bigorgne C, Kunlin A, Monconduit M, Bastard C
    Blood. 1994 ; 84 (4) : 1043-1049.
    PMID 8049424


    This paper should be referenced as such :
    Cuneo, A ; Castoldi, GL
    del(17p) in non-Hodgkin's lymphoma (NHL)
    Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):31-32.
    Free journal version : [ pdf ]   [ DOI ]
    On line version :

    Other genes implicated (Data extracted from papers in the Atlas) [ 1 ]

    Genes CD38

    Translocations implicated (Data extracted from papers in the Atlas)

     del(17p) in non-Hodgkin's lymphoma (NHL)

    External links

    Mitelman databasedel(17p)
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