del(17p) in non-Hodgkin's lymphoma (NHL)

Identity

ICD-Topo	C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id	2083
Note	the 17p- chromosome is a secondary change in most cases of NHL
	del(17p)  Hybridization with the LSI p53/CEP17 and LSI p53 probes (Abbott molecular, US) showing 2 green and 2 red signals on normal metaphase (A) and only 1 red signal in metaphase and interphase cells with 17p deletion (B,C) – Courtesy Adriana Zamecnikova. Insert: del(17p) G- banding – Top: Courtesy Melanie Zenger and Claudia Haferlach: Bottom: – Courtesy Adriana Zamecnikova.

Clinics and Pathology

Disease

virtually all histologic subsets of NHL may harbour a 17p- chromosome; there is variation in the reported incidence due to heterogeneity of histologic classification and to the different sensitivity of the detection methods 10 to 15% of follicle centre cell lymphoma (FCCL) and mantle cell lymphomas (MCL) may carry a 17p- chromosome; minority of marginal zone B-cell lymphomas may be associated with 17p deletion this anomaly is rarely found in T-cell NHL

Prognosis

the 17p- chromosome was reported to predict for a poor prognosis in low grade lymphomas; any abnormality of chromosome 17 was also reported to negatively affect survival in lymphomas of all histologic grades

Cytogenetics

Cytogenetics Morphological

the deleted segment may vary in size and many cases with sub-microscopic deletions involving the 17p13 band were reported by FISH; cases with unbalanced 17p translocations leading to 17p loss were also described; these cases may be associated with dicentric rearrangements the 17p- is usually associated with transformation of a low-grade FCCL with t(14;18) into a high grade lymphoma; likewise, there is a higher incidence of 17p- in the blastoid variant of MCL with t(11,14) than in the typical form

Cytogenetics Molecular

the deletion may be detected by G or R-banding; FISH using a 17p13/p53 probe is recommended, this technique being more sensitive than conventional cytogenetics

Genes involved and Proteins

Note	the majority of cases with 17p- carry a p53 gene deletion, associated with mutation of the remaining allele; there may be a small fraction of cases with a more distal deletion involving an as yet unidentified locus

Bibliography

Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants.

Beá S, Ribas M, Hernández JM, Bosch F, Pinyol M, Hernández L, García JL, Flores T, González M, López-Guillermo A, Piris MA, Cardesa A, Montserrat E, Miró R, Campo E

Blood. 1999 ; 93 (12) : 4365-4374.

PMID 10361135

Refractoriness to chemotherapy and poor survival related to abnormalities of chromosomes 17 and 7 in lymphoma.

Cabanillas F, Pathak S, Grant G, Hagemeister FB, McLaughlin P, Swan F, Rodriguez MA, Trujillo J, Cork A, Butler JJ

The American journal of medicine. 1989 ; 87 (2) : 167-172.

PMID 2757057

Translocations involving the short arm of chromosome 17 in chronic B-lymphoid disorders: frequent occurrence of dicentric rearrangements and possible association with adverse outcome.

Callet-Bauchu E, Salles G, Gazzo S, Poncet C, Morel D, Pagès J, Coiffier B, Coeur P, Felman P

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1999 ; 13 (3) : 460-468.

PMID 10086737

Analysis of p53 gene deletions in patients with non-Hodgkin's lymphoma by dual-colour fluorescence in-situ hybridization.

Clodi K, Younes A, Goodacre A, Roberts M, Palmer J, Younes M, Cabanillas F, Andreeff M

British journal of haematology. 1997 ; 98 (4) : 913-921.

PMID 9326189

Molecular cytogenetic characterization of marginal zone B-cell lymphoma: correlation with clinicopathologic findings in 14 cases.

Cuneo A, Bigoni R, Roberti MG, Milani R, Agostini P, Cavazzini F, Minotto C, De Angeli C, Bardi A, Tammiso E, Negrini M, Cavazzini P, Castoldi G

Haematologica. 2001 ; 86 (1) : 64-70.

PMID 11146573

Identification of a commonly deleted region at 17p13.3 in leukemia and lymphoma associated with 17p abnormality.

Sankar M, Tanaka K, Kumaravel TS, Arif M, Shintani T, Yagi S, Kyo T, Dohy H, Kamada N

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (4) : 510-516.

PMID 9557609

Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low-grade and high-grade lymphomas.

Schlegelberger B, Himmler A, Gödde E, Grote W, Feller AC, Lennert K

Blood. 1994 ; 83 (2) : 505-511.

PMID 8286748

Prognostic value of chromosomal abnormalities in follicular lymphoma.

Tilly H, Rossi A, Stamatoullas A, Lenormand B, Bigorgne C, Kunlin A, Monconduit M, Bastard C

Blood. 1994 ; 84 (4) : 1043-1049.

PMID 8049424

Citation

This paper should be referenced as such :

Cuneo, A ; Castoldi, GL

del(17p) in non-Hodgkin's lymphoma (NHL)

Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):31-32.

Free journal version : [ pdf ]   [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Anomalies/del17pNHLID2083.html

Translocations implicated (Data extracted from papers in the Atlas)

	del(17p) in non-Hodgkin's lymphoma (NHL)

External links

Mitelman database	del(17p) [Case List]    del(17p) [Transloc-MCList] in [Fusion-MCList]
arrayMap (UZH-SIB Zurich)	[select an item]

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
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indexed on : Wed Nov 28 16:16:45 CET 2018

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