Written | 2000-12 | Antonio Cuneo, Gianluigi Castoldi |
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy |
Identity |
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
Atlas_Id | 2083 |
Note | the 17p- chromosome is a secondary change in most cases of NHL |
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del(17p) Hybridization with the LSI p53/CEP17 and LSI p53 probes (Abbott molecular, US) showing 2 green and 2 red signals on normal metaphase (A) and only 1 red signal in metaphase and interphase cells with 17p deletion (B,C) – Courtesy Adriana Zamecnikova. Insert: del(17p) G- banding – Top: Courtesy Melanie Zenger and Claudia Haferlach: Bottom: – Courtesy Adriana Zamecnikova. | |
Clinics and Pathology |
Disease | virtually all histologic subsets of NHL may harbour a 17p- chromosome; there is variation in the reported incidence due to heterogeneity of histologic classification and to the different sensitivity of the detection methods |
Prognosis | the 17p- chromosome was reported to predict for a poor prognosis in low grade lymphomas; any abnormality of chromosome 17 was also reported to negatively affect survival in lymphomas of all histologic grades |
Cytogenetics |
Cytogenetics Morphological | |
Cytogenetics Molecular | the deletion may be detected by G or R-banding; FISH using a 17p13/p53 probe is recommended, this technique being more sensitive than conventional cytogenetics |
Genes involved and Proteins |
Note | the majority of cases with 17p- carry a p53 gene deletion, associated with mutation of the remaining allele; there may be a small fraction of cases with a more distal deletion involving an as yet unidentified locus |
Bibliography |
Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants. |
Beá S, Ribas M, Hernández JM, Bosch F, Pinyol M, Hernández L, García JL, Flores T, González M, López-Guillermo A, Piris MA, Cardesa A, Montserrat E, Miró R, Campo E |
Blood. 1999 ; 93 (12) : 4365-4374. |
PMID 10361135 |
Refractoriness to chemotherapy and poor survival related to abnormalities of chromosomes 17 and 7 in lymphoma. |
Cabanillas F, Pathak S, Grant G, Hagemeister FB, McLaughlin P, Swan F, Rodriguez MA, Trujillo J, Cork A, Butler JJ |
The American journal of medicine. 1989 ; 87 (2) : 167-172. |
PMID 2757057 |
Translocations involving the short arm of chromosome 17 in chronic B-lymphoid disorders: frequent occurrence of dicentric rearrangements and possible association with adverse outcome. |
Callet-Bauchu E, Salles G, Gazzo S, Poncet C, Morel D, Pagès J, Coiffier B, Coeur P, Felman P |
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1999 ; 13 (3) : 460-468. |
PMID 10086737 |
Analysis of p53 gene deletions in patients with non-Hodgkin's lymphoma by dual-colour fluorescence in-situ hybridization. |
Clodi K, Younes A, Goodacre A, Roberts M, Palmer J, Younes M, Cabanillas F, Andreeff M |
British journal of haematology. 1997 ; 98 (4) : 913-921. |
PMID 9326189 |
Molecular cytogenetic characterization of marginal zone B-cell lymphoma: correlation with clinicopathologic findings in 14 cases. |
Cuneo A, Bigoni R, Roberti MG, Milani R, Agostini P, Cavazzini F, Minotto C, De Angeli C, Bardi A, Tammiso E, Negrini M, Cavazzini P, Castoldi G |
Haematologica. 2001 ; 86 (1) : 64-70. |
PMID 11146573 |
Identification of a commonly deleted region at 17p13.3 in leukemia and lymphoma associated with 17p abnormality. |
Sankar M, Tanaka K, Kumaravel TS, Arif M, Shintani T, Yagi S, Kyo T, Dohy H, Kamada N |
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (4) : 510-516. |
PMID 9557609 |
Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low-grade and high-grade lymphomas. |
Schlegelberger B, Himmler A, Gödde E, Grote W, Feller AC, Lennert K |
Blood. 1994 ; 83 (2) : 505-511. |
PMID 8286748 |
Prognostic value of chromosomal abnormalities in follicular lymphoma. |
Tilly H, Rossi A, Stamatoullas A, Lenormand B, Bigorgne C, Kunlin A, Monconduit M, Bastard C |
Blood. 1994 ; 84 (4) : 1043-1049. |
PMID 8049424 |
Citation |
This paper should be referenced as such : |
Cuneo, A ; Castoldi, GL |
del(17p) in non-Hodgkin's lymphoma (NHL) |
Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):31-32. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Anomalies/del17pNHLID2083.html |
Other genes implicated (Data extracted from papers in the Atlas) [ 1 ] |
Genes | CD38 |
Translocations implicated (Data extracted from papers in the Atlas) |
del(17p) in non-Hodgkin's lymphoma (NHL) | |
External links |
Mitelman database | del(17p) |
arrayMap (UZH-SIB Zurich) | [select an item] |
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:24:28 CET 2020 |
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