del(5q) in acute lymphoblastic leukemia (ALL)

Abstract

Myelodysplatic syndrome (MDS) with an isolated 5q deletion (5q-syndrome), that may arise de novo or may be therapy-related is recognized as a distinct entity by the WHO classification. While del(5q) thought to contribute to the pathogenesis of myeloid neoplasms, it has also been reported in lymphoblastic leukemia, suggesting a common underlying mechanism.

Keywords

Myelodysplastic syndrome; acute lymphoblastic leukemia; lenalidomide; 5q- syndrome; tumor suppressor genes.

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Identity

ICD-Topo	C420,C421,C424
ICD-Morpho	9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho	9837/3 T lymphoblastic leukaemia/lymphoma
Atlas_Id	1768
	Figure 1. (A). Fluorescence in situ hybridization with Vysis LSI CSF1R (5q33-34)/5p15.2 probe (Abott Molecular/Vysis, US) showing 2 red and 2 green signals on a normal metaphase and only 1 red signal on a metaphase with 5q deletion. Inset: Partial karyotype with 5q deletion and with chromosome 5 in 'action' (chromosome 5 breaks).

Clinics and Pathology

Disease	Acute lymphoblastic leukemia
Etiology	Acute leukemia evolving from an underlying MDS with del(5q) is almost always of myeloid lineage and only anecdotal case reports of MDS transforming to ALL have been reported (Agostino et al., 2011; Jain et al., 2016). Whether the presence of del(5q) in these cases reflects the underlying myelodysplastic state that later evolved into ALL remains unclear. del(5q) in ALL is mostly associated with multiple cytogenetic abnormalities that thought to be due to clonal expansion from an abnormal pluripotent stem cell.
Epidemiology	At least 160 reported patients aged 0 to 86 years (98 males, 61 females, 1 unknown); prevalence of pediatric patients (86 patients) and there were 46 adults. B-cell acute lymphoblastic leukemia: 70 patients aged 0 to 86 years (41 males and 28 females, 1 unknown); among them there were 22 adults (14 males and 8 females, aged 22 to 86 years; median 42 years) and 39 pediatric patients (22 males and 17 females, aged 0 to 18; median 6 years). In addition, there were 9 patients with unknown age (5 males and 3 females, 1 unknown). T-cell acute lymphoblastic leukemia: 58 patients (35 males and 23 females aged 1 to 79 years); among them there were 17 adults (9 males and 8 females aged 19 to 79 years), 35 pediatric patients (22 males 13 females aged 1 to 18 years) and 6 patients with unknown age (4 males and 2 females). 32 patients had unspecified ALL (22 males, 10 females aged 3 to 81 years; median 13 years); 7 patients were adults (5 males and 2 females) aged 34 to 81 years (median 72 years), 12 were pediatric patients (8 males and 4 females aged 3 to 16 years; median 6 years) and there were 12 patients with unknown age (8 males and 4 females).
Clinics	In contrast to its presence in myeloid malignancies, isolated del(5q) is rare in ALL, thus its clinical significance is unknown. del(5q) also appears to be clinically insignificant in patients following cytotoxic therapy or tyrosine kinase inhibitor (TKI) therapy, similar to other clonal cytogenetic abnormalities if detected as a minor clone (Tang et al., 2015). del(5q) in ALL mainly found as a clonal evolution event associated with disease progression.

Genetics

Del(5q) may be found as sole abnormality at first, as an evolutionary event in other cases, and as a transient event in patients after being treated with cytotoxic agents or TKI for the prior malignancies.

Cytogenetics

Cytogenetics Morphological

Excluded are patients with EBF1/PDGFRB fusion that arose from interstitial deletion of 5q33, occurring within the Philadelphia-like ALL subtype. Del(5q) as a sole clonal cytogenetic abnormality was found in 11 patients (3 with B-ALL, 4 with T-ALL and 4 with unspecified ALL) (Kowalczyk et al., 1985; Brusamolino et al., 1988; Raimondi et al., 1988; Loncarevic et al., 1999; Midmer et al., 1999; Gmidene et al., 2008; Palau et al., 1991; Valtat et al., 1991; Theodossiou et al., 1992; Goud et al., 2015). Among these patients, there was and a 5-year-old boy who had previously received chemotherapy for ALL that had been diagnosed nine months before (Palau et al., 1991), a 13-year-old boy in whom the rearrangement was transiently present 7 months following the diagnosis of Ph-positive ALL (Theodossiou et al., 1992). Del(5q)with other abnormalities Found in a sideline with del(20q) and +Y in 2 MDS patients transforming to B-ALL while on lenalidomide (Agostino et al., 2011) and with limited additional anomalies such as i(7)(q10) in 1 (Kaneko et al., 1989), +22 in 1 (Karst et al., 2006), der(19)t(1;19)(q23;p13) in 1 (Chen et al., 1992) and 1 had a clone with a Ph chromosome and del(5q) at diagnosis (Takechi et al., 1990). The t(12;21)(p13;q22) was present as a sole additional anomaly in 3 patients with B-cell ALL (Lu et al., 2002; South et al., 2006; Zhou et al., 2012) and in 8 it was part of a complex karyotype (Alvarez et al., 2005; Kuchinskaya et al., 2005; Jarosova et al., 2003; Martineau et al., 2005; Olsson et al., 2018), however it is possible that some additional pediatric patients had a cryptic t(12;21). 3 patients had dic(9;20) (Heerema et al., 1996; Strefford et al., 2007; An et al., 2008), 10 t(9;22) (q34;q11) (Sessarego et al., 1991; Tsuchiya et al., 1995; Rieder et al., 1996; Lee et al., 2002; Onciu et al., 2002; Wetzler et al., 2004; Russell et al., 2008; De Braekeleer et al., 2010; Lundin et al., 2014; Olsson et al., 2018) in complex karyotypes. The majority of patients with T-ALL had karyotypes with combination of chromosome deletions and specific translocations such as t(4;11)(q21;p15) (Hussey et al., 1999), t(5;14)/HOX11L2 (Berger et al., 2003; Bernard et al., 2001), t(4;11)(q23;p15) (Zhang et al., 2012), t(7;10)(q34;q24) (Lai et al., 2000), t(7;11)(q35;p13) (Kaneko et al. ID: >1998), t(10;11)(p12;q21) (Matlawska-Wasowska et al., 2016), t(10;14)(q24;q11) (Grossmann et al., 2013) and inv(7)(p15q34) (Rowley et al., 1999; La Starza et al., 2016).

Genes involved and Proteins

Note	Deletions of 5q are heterozygous, and deleted regions can affect different genes that are involved in the regulation of hematopoiesis.

Result of the chromosomal anomaly

Fusion Protein

Oncogenesis

Interstitial or terminal deletions of the long arm of chromosome 5 are common findings in MDS or acute myeloid leukemia (AML), but they may also occur in patients with ALL. Deletions of genetic material from 5q result in loss of tumor suppressor genes that may potentially play a role in the pathogenesis of these diseases. The long arm of chromosome 5 contains many genes that are relevant in hematopoiesis and several candidate genes including transcription factors, cytokines and their receptors, signal mediators and cell cycle regulators have been identified. These include the RPS14 gene on 5q33.1, a critical gene for the erythroid phenotype, a microRNA cluster on 5q32-33 important for the megakaryocytic phenotype, the EGR1 gene on 5q31 that plays a role in hematopoietic stem cell proliferation. Other genes such as NPM1 and APC, the transcription factor Egr1/Krox20, the cytoskeletal remodeling protein, alpha-catenin may also contribute to the disease phenotype and progression (Tang et al., 2015). Although a critical tumor suppressor gene has not yet been identified in ALL, several putative tumor suppressors such as NR3C1 and TCF7, located within the 5q31 common deleted region and TRIM41, ZFP62, MAPK9, MGAT1, and CNOT6, mapping at 5q35 have been found to be down-regulated in T- ALL (La Starza et al.,2016). Given the large size and variable pattern of 5q deletions, it is probable that the loss of several genes that act alone or in combination contribute to pathogenesis. The absence of a clear critical gene suggests that deletion of variable combinations of genes may result in a clinical spectrum ranging from myeloid malignancies to lymphoid leukemia.

Bibliography

Transformation of the 5q- syndrome to acute lymphoblastic leukemia: a report of two cases and review of the literature

Agostino NM, Ahmed B, Popescu D, Gheith S

Int J Clin Exp Pathol 2011 Mar;4(3):322-6

PMID 21487529

Genetic abnormalities associated with the t(12;21) and their impact in the outcome of 56 patients with B-precursor acute lymphoblastic leukemia

Alvarez Y, Coll MD, Ortega JJ, Bastida P, Dastugue N, Robert A, Cervera J, Verdeguer A, Tasso M, Aventín A, Guitart M, Caballín MR

Cancer Genet Cytogenet 2005 Oct 1;162(1):21-9

PMID 16157196

Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer

An Q, Wright SL, Konn ZJ, Matheson E, Minto L, Moorman AV, Parker H, Griffiths M, Ross FM, Davies T, Hall AG, Harrison CJ, Irving JA, Strefford JC

Proc Natl Acad Sci U S A 2008 Nov 4;105(44):17050-4

PMID 18957548

t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia

Berger R, Dastugue N, Busson M, Van Den Akker J, Pérot C, Ballerini P, Hagemeijer A, Michaux L, Charrin C, Pages MP, Mugneret F, Andrieux J, Talmant P, Hélias C, Mauvieux L, Lafage-Pochitaloff M, Mozziconacci MJ, Cornillet-Lefebvre P, Radford I, Asnafi V, Bilhou-Nabera C, Nguyen Khac F, Léonard C, Speleman F, Poppe B, Bastard C, Taviaux S, Quilichini B, Herens C, Grégoire MJ, Cavé H, Bernard OA; Groupe Français de Cytogénétique Hématologique (GFCH)

A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH) Leukemia

PMID 12970786

A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia

Bernard OA, Busson-LeConiat M, Ballerini P, Mauchauffé M, Della Valle V, Monni R, Nguyen Khac F, Mercher T, Penard-Lacronique V, Pasturaud P, Gressin L, Heilig R, Daniel MT, Lessard M, Berger R

Leukemia 2001 Oct;15(10):1495-504

PMID 11587205

Hematologic and clinical features of patients with chromosome 5 monosomy or deletion (5q)

Brusamolino E, Orlandi E, Morra E, Bernasconi P, Pagnucco G, Colombo A, Lazzarino M, Bernasconi C

Med Pediatr Oncol 1988;16(2):88-94

PMID 3352540

Non-random involvement of chromosome 5 in ALL

Chen Z, Morgan R, Sandberg AA

Cancer Genet Cytogenet 1992 Jul 1;61(1):106-7

PMID 1638475

Philadelphia chromosome-positive acute lymphoblastic leukemia: a cytogenetic study of 33 patients diagnosed between 1981 and 2008

De Braekeleer E, Douet-Guilbert N, Morel F, Le Bris MJ, Basinko A, Berthou C, Morice P, Férec C, De Braekeleer M

Anticancer Res 2010 Feb;30(2):569-73

PMID 20332472

Loss of heterozygosity on chromosome 5 in adults with acute lymphoblastic leukemia

Faderl S, Gidel C, Kantarjian HM, Manshouri T, Keating M, Albitar M

Leuk Res 2001 Jan;25(1):39-43

PMID 11137559

Cytogenetic analysis of 298 newly diagnosed cases of acute lymphoblastic leukaemia in Tunisia

Gmidène A, Sennana H, Elghezal H, Ziraoui S, Youssef YB, Elloumi M, Issaoui L, Harrabi I, Raynaud S, Saad A

Hematol Oncol 2008 Jun;26(2):91-7

PMID 18271061

Importance of FISH combined with Morphology, Immunophenotype and Cytogenetic Analysis of Childhood/ Adult Acute Lymphoblastic Leukemia in Omani Patients

Goud TM, Al Salmani KK, Al Harasi SM, Al Musalhi M, Wasifuddin SM, Rajab A

Asian Pac J Cancer Prev 2015;16(16):7343-50

PMID 26514535

The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL

Grossmann V, Haferlach C, Weissmann S, Roller A, Schindela S, Poetzinger F, Stadler K, Bellos F, Kern W, Haferlach T, Schnittger S, Kohlmann A

Genes Chromosomes Cancer 2013 Apr;52(4):410-22

PMID 23341344

Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group

Heerema NA, Sather HN, Sensel MG, Kraft P, Nachman JB, Steinherz PG, Lange BJ, Hutchinson RS, Reaman GH, Trigg ME, Arthur DC, Gaynon PS, Uckun FM

J Clin Oncol 1998 Apr;16(4):1270-8

PMID 9552025

The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia

Hussey DJ, Nicola M, Moore S, Peters GB, Dobrovic A

Blood 1999 Sep 15;94(6):2072-9

PMID 10477737

Synchronous del5q myelodysplastic syndrome (del5qMDS) and adult B-cell acute lymphoblastic leukemia (B-ALL) with TET2 and TP53 mutations

Jain P, Tang G, Konoplev SN, Kanagal-Shamanna R, Wang SA, Pemmaraju N, Daver N, Estrov Z

Am J Hematol 2016 Mar;91(3):354-5

PMID 26437693

Chromosomal aberrations in childhood acute lymphoblastic leukemia: 15-year single center experience

Jarosova M, Volejnikova J, Porizkova I, Holzerova M, Pospisilova D, Novak Z, Vrbkova J, Mihal V

Cancer Genet 2016 Jul-Aug;209(7-8):340-7

PMID 27341996

Chromosomal and immunophenotypic patterns in T cell acute lymphoblastic leukemia (T ALL) and lymphoblastic lymphoma (LBL)

Kaneko Y, Frizzera G, Shikano T, Kobayashi H, Maseki N, Sakurai M

Leukemia 1989 Dec;3(12):886-92

PMID 2586183

Chromosome translocations involving band 7q35 or 7p15 in childhood T-cell leukemia/lymphoma

Kaneko Y, Maseki N, Homma C, Sakurai M, Mizutani S, Takeda T, Shikano T, Fujimoto T, Yaoi K, Shimokawa T

Blood 1988 Aug;72(2):534-8

PMID 2900030

Novel cryptic chromosomal rearrangements detected in acute lymphoblastic leukemia detected by application of new multicolor fluorescent in situ hybridization approaches

Karst C, Gross M, Haase D, Wedding U, Höffken K, Liehr T, Mkrtchyan H

Int J Oncol 2006 Apr;28(4):891-7

PMID 16525638

A possible subgroup of ALL with 9p-

Kowalczyk J, Sandberg AA

Cancer Genet Cytogenet 1983 Aug;9(4):383-5

PMID 6575861

Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles

Kuchinskaya E, Heyman M, Grandér D, Linderholm M, Söderhäll S, Zaritskey A, Nordgren A, Porwit-Macdonald A, Zueva E, Pawitan Y, Corcoran M, Nordenskjöld M, Blennow E

Eur J Haematol 2005 Jun;74(6):466-80

PMID 15876250

Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia

La Starza R, Barba G, Demeyer S, Pierini V, Di Giacomo D, Gianfelici V, Schwab C, Matteucci C, Vicente C, Cools J, Messina M, Crescenzi B, Chiaretti S, Foà R, Basso G, Harrison CJ, Mecucci C

Haematologica 2016 Aug;101(8):951-8

PMID 27151989

Flow cytometric detection of CD79a expression in T-cell acute lymphoblastic leukemias

Lai R, Juco J, Lee SF, Nahirniak S, Etches WS

Am J Clin Pathol 2000 Jun;113(6):823-30

PMID 10874883

Influence of karyotype on outcome of allogeneic bone marrow transplantation for adults with precursor B-lineage acute lymphoblastic leukaemia in first or second remission

Lee S, Kim DW, Kim YJ, Park YH, Min CK, Lee JW, Min WS, Kim CC

Br J Haematol 2002 Apr;117(1):109-18

PMID 11918540

Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion

Loncarevic IF, Roitzheim B, Ritterbach J, Viehmann S, Borkhardt A, Lampert F, Harbott J

Genes Chromosomes Cancer 1999 Mar;24(3):272-7

PMID 10451708

The utility of spectral karyotyping in the cytogenetic analysis of newly diagnosed pediatric acute lymphoblastic leukemia

Lu XY, Harris CP, Cooley L, Margolin J, Steuber PC, Sheldon M, Rao PH, Lau CC

Leukemia 2002 Nov;16(11):2222-7

PMID 12399965

Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries

Lundin C, Forestier E, Klarskov Andersen M, Autio K, Barbany G, Cavelier L, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kjeldsen E, Nordgren A, Palmqvist L, Johansson B; Nordic Society of Pediatric Hematology Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG)

J Hematol Oncol 2014 Apr 11;7:32

PMID 24726034

ETV6/RUNX1 fusion at diagnosis and relapse: some prognostic indications

Martineau M, Jalali GR, Barber KE, Broadfield ZJ, Cheung KL, Lilleyman J, Moorman AV, Richards S, Robinson HM, Ross F, Harrison CJ

Genes Chromosomes Cancer 2005 May;43(1):54-71

PMID 15704129

MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children's Oncology Group Study

Matlawska-Wasowska K, Kang H, Devidas M, Wen J, Harvey RC, Nickl CK, Ness SA, Rusch M, Li Y, Onozawa M, Martinez C, Wood BL, Asselin BL, Chen IM, Roberts KG, Baruchel A, Soulier J, Dombret H, Zhang J, Larson RS, Raetz EA, Carroll WL, Winick NJ, Aplan PD, Loh ML, Mullighan CG, Hunger SP, Heerema NA, Carroll AJ, Dunsmore KP, Winter SS

Leukemia 2016 Sep;30(9):1909-12

PMID 26952838

Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion

Midmer M, Haq R, Squire JA, Zanke BW

Cancer Res 1999 Aug 15;59(16):4069-74

Cooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations of IKZF1

Olsson L, Albitar F, Castor A, Behrendtz M, Biloglav A, Paulsson K, Johansson B

Genes Chromosomes Cancer 2015 May;54(5):315-25

PMID 25727050

Improved cytogenetic characterization and risk stratification of pediatric acute lymphoblastic leukemia using single nucleotide polymorphism array analysis: A single center experience of 296 cases

Olsson L, Lundin-Ström KB, Castor A, Behrendtz M, Biloglav A, Norén-Nyström U, Paulsson K, Johansson B

Genes Chromosomes Cancer 2018 Nov;57(11):604-607

PMID 30203896

Acute lymphoblastic leukemia in elderly patients the Philadelphia chromosome may not be a significant adverse prognostic factor

Onciu M, Bueso-Ramos C, Medeiros LJ, Ball G, Smith T, Lai R

Am J Clin Pathol 2002 May;117(5):716-20

PMID 12090419

Chromosome 5 abnormalities in acute lymphoblastic leukemia

Palau F, Prieto F, Badia L, Beneyto M, Benet I

Cancer Genet Cytogenet 1991 Apr;52(2):173-9

PMID 2021919

Cytogenetics of childhood T-cell leukemia

Raimondi SC, Behm FG, Roberson PK, Pui CH, Rivera GK, Murphy SB, Williams DL

Blood 1988 Nov;72(5):1560-6

PMID 3263151

Prognostic significance of additional chromosome abnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukaemia

Rieder H, Ludwig WD, Gassmann W, Maurer J, Janssen JW, Gökbuget N, Schwartz S, Thiel E, Löffler H, Bartram CR, Hoelzer D, Fonatsch C

Br J Haematol 1996 Dec;95(4):678-91

PMID 8982045

Spectral karyotype analysis of T-cell acute leukemia

Rowley JD, Reshmi S, Carlson K, Roulston D

Blood 1999 Mar 15;93(6):2038-42

PMID 10068677

t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)

Russell LJ, Akasaka T, Majid A, Sugimoto KJ, Loraine Karran E, Nagel I, Harder L, Claviez A, Gesk S, Moorman AV, Ross F, Mazzullo H, Strefford JC, Siebert R, Dyer MJ, Harrison CJ

Blood 2008 Jan 1;111(1):387-91

PMID 17940204

Involvement of the short arm of the derivative chromosome 9 in Philadelphia-positive acute lymphoblastic leukemia

Sessarego M, Defferrari R, Fugazza G, Comelli A, Salvidio E, Ajmar F

Cancer Genet Cytogenet 1991 Mar;52(1):43-9

PMID 2009511

Unexpected cytogenetic finding in acute lymphoblastic leukemia: a case of del(5q) with a cryptic t(12;21)

South ST, Frazer JK, Brothman AR, Chen Z

Cancer Genet Cytogenet 2006 Jul 15;168(2):177-8

PMID 16843112

Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization

Strefford JC, Worley H, Barber K, Wright S, Stewart AR, Robinson HM, Bettney G, van Delft FW, Atherton MG, Davies T, Griffiths M, Hing S, Ross FM, Talley P, Saha V, Moorman AV, Harrison CJ

Oncogene 2007 Jun 21;26(29):4306-18

PMID 17237825

Acute T-lymphocytic leukemia with Ph1 and 5q-chromosome abnormalities and rearrangements of bcr and TCR-delta genes

Takechi M, Ohnishi A, Tanaka K, Kimura N, Kamada N

Leuk Res 1990;14(10):885-93

PMID 2147972

Isolated del(5q) in Patients Following Therapies for Various Malignancies May Not All Be Clinically Significant

Tang G, Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, DiNardo C, Medeiros LJ

Am J Clin Pathol 2015 Jul;144(1):78-86

PMID 26071464

del(5q) in acute lymphoblastic leukemia with biphenotypic and early progenitor phenotype

Theodossiou C, Scalise A, Troy K, Silverman L, Perdahl-Wallace E, Najfeld V

Cancer Genet Cytogenet 1992 Oct 15;63(2):89-94

A late-appearing Philadelphia chromosome in acute lymphoblastic leukemia confirmed by expression of BCR-ABL mRNA

Tsuchiya H, Migita M, Yamamori S, Kaneko Y, Adachi N, Nakamura T, Nobukuni Y, el-Sonbaty SS, Matsuda I

Leukemia 1995 Oct;9(10):1689-93

PMID 7564511

Mosaic 46,XY/92,XXYY,del(5)(q13 q34) in an adult lymphoblastic leukemia

Valtat C, Uettwiller F, Flori E, Valtat B, Ruch JV, Oberling F

Leuk Res 1991;15(7):651-3

PMID 1861547

Additional cytogenetic abnormalities in adults with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a study of the Cancer and Leukaemia Group B

Wetzler M, Dodge RK, Mrózek K, Stewart CC, Carroll AJ, Tantravahi R, Vardiman JW, Larson RA, Bloomfield CD

Br J Haematol 2004 Feb;124(3):275-88

PMID 14717774

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG

Nature 2012 Jan 11;481(7380):157-63

PMID 22237106

Detection of ETV6 gene rearrangements in adult acute lymphoblastic leukemia

Zhou MH, Gao L, Jing Y, Xu YY, Ding Y, Wang N, Wang W, Li MY, Han XP, Sun JZ, Wang LL, Yu L

Ann Hematol 2012 Aug;91(8):1235-43

PMID 22373549

Citation

This paper should be referenced as such :

Adriana Zamecnikova, Soad al Bahar

del(5q) in acute lymphoblastic leukemia (ALL)

Atlas Genet Cytogenet Oncol Haematol. 2020;24(6):248-252.

Free journal version : [ pdf ]   [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Anomalies/del5qALLID1768.html

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