Disease |
Myeloid malignancies and acute lymphoblastic leukemia (ALL). |
Etiology | Deletion of 7p as the sole abnormality occurs in disorders with myelodysplastic or myeloproliferative features and acute lymphoblastic leukemia, and may therefore affect early hematopoietic progenitor cells. |
Epidemiology | Myeloproliferative disorders mainly: chronic myeloproliferative disorder in 9 (balanced sex ratio; 4 males and 5 females aged 53 to 79 years old, median age 63 years) (Bernstein et al., 1980; CML Yunis et al., 1986; Obeid et al., 1989; Palka et al., 1990; Rodjer et al., 1990; Ohyashiki et al., 1993; Pedersen-Bjergaard et al., 1993; Lezon-Geyda et al., 2001; Maciejewski et al., 2002) and AML in 10 patients (4 males and 6 females, aged 0 to 80 years, median age 0 years) (Bernstein et al., 1984; Testa et al., 1985; Mecucci et al., 1989; Abruzzo et al., 1992; Veldman et al., 1997; Chessells et al., 2002; Babicka et al., 2007; Blink et al., 2012). Male prevalence and prevalence of T-cell phenotype and in ALL (6 males and 2 females aged 3 to 50 years, median age 25 years) (Kaneko et al., 1989; Berger et al., 1990; Bernard et al., 2001; Berger et al., 2003; Douet-Guilbert et al., 2004; Mullighan et al., 2009; Russell et al., 2009; Safavi et al., 2015). 5 patients with myeloid malignancies had secondary disorders treated for a previous malignancy (Mecucci et al., 1989; Rodjer et al., 1990; Abruzzo et al., 1992; Pedersen-Bjergaard et al., 1993). Three patients were Down syndrome patients (Table 1). Chronic myeloproliferative disorders | 1 | F/64 | CMD | 46,XX,del(7)(p11) | 2 | M/71 | RAEB | 46,XY,del(7)(p11p22) | 3 | F/62 | CMMoL | 46,XX,del(7)(p11) | 4 | F/68 | RAEB | 46,XX,del(7)(p13) | 5 | M/62 | RA | 45,XY,-10/46,XY,del(7)(p13p14) multiple myeloma, chemotherapy | 6 | F | RA | 46,XX,del(7)(p14) | 7 | F/63 | MDS | 46,XX,del(7)(p11) 46,XX,-7,+21 multiple myeloma, chemotherapy | 8 | M/76 | MDS | 46,XY,del(7)(p12p15) | 9 | M/53 | RA | 47,XY,del(7)(p13p22) | Acute myeloid leukemia | 10 | M/7 | AML-M2 | 46,XY,del(7)(p11) | 11 | M/51 | AML-M1 | 46,XY,del(7)(p1?5) | 12 | F/20 | AML-M4 | 46,XX,del(7)(p14 | 13 | M/47 | AML-M2 | 46,XY,del(7)(p12p21) Hodgkin disease, chemotherapy, radiotherapy | 14 | F/80 | AML-M4 | 46,XX,del(7)(p12p21) polycythemia vera, chemotherapy, radiotherapy | 15 | F/11 | AML | 46,XX,del(7)(p12) mature B-cell neoplasm, chemotherapy | 16 | F/57 | AML-M7 | 47,XX,del(7)(p?),+21c | 17 | F/0 | AML-M7 | 46,XX,del(7)(p15) | 18 | M/55 | AML-M0 | 46,XY,del(7)(p12)/46,idem,t(2;2)(q31;q35) | 19 | F/1 | AML | 47,XX,del(7)(p11),+21c | Acute lymphoblastic leukemia | 20 | M/14 | T-ALL | 46,XY,del(7)(p15) | 21 | M/25 | T-ALL | 46,XY,del(7)(p13p15) | 22 | M/25 | T-ALL | 46,XY,del(7)(p13) | 23 | M/29 | T-ALL | 46,XY,del(7)(p11p15) | 24 | M/50 | T-ALL | 46,XY,del(7)(p12) | 25 | F | ALL | 47,XX,del(7)(p13p15),+21c | 26 | F/3 | B-ALL | 47-48,XX,+17,del(20),+21,inc/46,XX,del(7)(p11) | 27 | M/30 | T-ALL | 46,XY,del(7)(p13) | Abbreviations: M, male; F, female; CMD, chronic myeloproliferative disorder; RAEB, refractory anemia with excess of blasts; MDS, myelodysplastic syndrome; CMMoL, chronic myelomonocytic leukemia; RA, refractory anemia; AML-M2, acute myeloblastic leukemia with maturation; AML-M1, acute myeloblastic leukemia without maturation; AML-M4, acute myelomonocytic leukemia; AML, acute myeloid leukemia; AML-M7, acute megakaryoblastic leukemia; AML-M5, acute monoblastic leukemia; AML-M0, acute myeloblastic leukemia with minimal differentiation, ALL, acute lymphoblastic leukemia/lymphoblastic lymphoma. 1. Bernstein et al., 1980; 2. Yunis et al., 1986; 3. Obeid et al., 1989; 4. Palka et al., 1990. 5. Rodjer et al., 1990; 6. Ohyashiki et al., 1993; 7. Pedersen-Bjergaard et al., 1993; 8. Lezon et al., 2001; 9. Maciejewski et al., 2002; 10. Bernstein et al., 1984; 11. Testa et al., 1985; 12-14. Mecucci et al., 1989; 15. Abruzzo et al., 1992; 16. Veldman et al., 1997; 17. Chessells et al., 2002; 18. Babicka et al., 2007; 19. Blink et al., 2012; 20. Kaneko et al., 1989; 21. Berger et al., 1990; 22. Bernard et al., 2001; 23. Berger et al., 2003; 24. Douet-Guilbert et al., 2004; 25. Mullighan et al., 2009; 26. Russell et al., 2009; 27. Safavi et al., 2015. |
Cytogenetics | Represents as interstitial (9 cases) or terminal deletion (18 patients) with various breakpoints. |
Prognosis | Deletion of 7p, appears to confer increased risk of treatment failure and inferior outcome, same as it observed with monosomy 7 in myeloid malignancies. Similarly, event-free survival and survival for patients with monosomy 7 or del(7p), but not of patients with del(7q), were significantly worse in ALL patients than those lacking these abnormalities suggesting the critical region of loss may be on the p-arm (Mecucci et al., 1989; Heerema et al. 2004). |
T-cell lymphoblastic lymphoma with eosinophilia associated with subsequent myeloid malignancy |
Abruzzo LV, Jaffe ES, Cotelingam JD, Whang-Peng J, Del Duca V Jr, Medeiros LJ |
Am J Surg Pathol 1992 Mar;16(3):236-45 |
PMID 1599015 |
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Analysis of complex chromosomal rearrangements in adult patients with MDS and AML by multicolor FISH |
Babicka L, Ransdorfova S, Brezinova J, Zemanova Z, Sindelarova L, Siskova M, Maaloufova J, Cermak J, Michalova K |
Leuk Res 2007 Jan;31(1):39-47 |
PMID 16687173 |
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t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia |
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A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH) Leukemia |
PMID 12970786 |
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Cytogenetic studies of 44 T-cell acute lymphoblastic leukemias |
Berger R, Le Coniat M, Vecchione D, Derré J, Chen SJ |
Cancer Genet Cytogenet 1990 Jan;44(1):69-75 |
PMID 2293882 |
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A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia |
Bernard OA, Busson-LeConiat M, Ballerini P, Mauchauffé M, Della Valle V, Monni R, Nguyen Khac F, Mercher T, Penard-Lacronique V, Pasturaud P, Gressin L, Heilig R, Daniel MT, Lessard M, Berger R |
Leukemia 2001 Oct;15(10):1495-504 |
PMID 11587205 |
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Chromosome patterns in 26 South African children with acute nonlymphocytic leukemia (ANLL) |
Bernstein R, Macdougall LG, Pinto MR |
Cancer Genet Cytogenet 1984 Feb;11(2):199-214 |
PMID 6692340 |
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High frequency of copy number alterations in myeloid leukaemia of Down syndrome |
Blink M, van den Heuvel-Eibrink MM, Aalbers AM, Balgobind BV, Hollink IH, Meijerink JP, van der Velden VH, Beverloo BH, de Haas V, Hasle H, Reinhardt D, Klusmann JH, Pieters R, Calado RT, Zwaan CM |
Br J Haematol 2012 Sep;158(6):800-3 |
PMID 22775985 |
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Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party |
Chessells JM, Harrison CJ, Kempski H, Webb DK, Wheatley K, Hann IM, Stevens RF, Harrison G, Gibson BE; MRC Childhood Leukaemia working party |
Leukemia 2002 May;16(5):776-84 |
PMID 11986937 |
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Cytogenetic studies in T-cell acute lymphoblastic leukemia (1981-2002) |
Douet-Guilbert N, Morel F, Le Bris MJ, Herry A, Le Calvez G, Marion V, Abgrall JF, Berthou C, De Braekeleer M |
Leuk Lymphoma 2004 Feb;45(2):287-90 |
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Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group |
Heerema NA, Nachman JB, Sather HN, La MK, Hutchinson R, Lange BJ, Bostrom B, Steinherz PG, Gaynon PS, Uckun FM; Children's Cancer Group |
Leukemia 2004 May;18(5):939-47 |
PMID 14999294 |
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Chromosomal and immunophenotypic patterns in T cell acute lymphoblastic leukemia (T ALL) and lymphoblastic lymphoma (LBL) |
Kaneko Y, Frizzera G, Shikano T, Kobayashi H, Maseki N, Sakurai M |
Leukemia 1989 Dec;3(12):886-92 |
PMID 2586183 |
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Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia |
Lezon-Geyda K, Najfeld V, Johnson EM |
Leukemia 2001 Jun;15(6):954-62 |
PMID 11417483 |
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Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia |
Maciejewski JP, Risitano A, Sloand EM, Nunez O, Young NS |
Blood 2002 May 1;99(9):3129-35 |
PMID 11964274 |
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Characterization of deletions of chromosome 7 short arm occurring as primary karyotypic anomaly in acute myeloid leukaemia |
Mecucci C, Van Orshoven A, Boogaerts M, Michaux JL, Van den Berghe H |
Br J Haematol 1989 Jan;71(1):13-7 |
PMID 2917120 |
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Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia |
Mullighan CG, Collins-Underwood JR, Phillips LA, Loudin MG, Liu W, Zhang J, Ma J, Coustan-Smith E, Harvey RC, Willman CL, Mikhail FM, Meyer J, Carroll AJ, Williams RT, Cheng J, Heerema NA, Basso G, Pession A, Pui CH, Raimondi SC, Hunger SP, Downing JR, Carroll WL, Rabin KR |
Nat Genet 2009 Nov;41(11):1243-6 |
PMID 19838194 |
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Deletion of the short arm of chromosome 7 in chronic monocytic leukaemia undergoing blast cell transformation |
Obeid D, Gould C, Creasy M |
Br J Haematol 1989 Apr;71(4):561-2 |
PMID 2713275 |
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Clinical and cytogenetic significance of myelodysplastic syndromes with disease evolution |
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Cancer Genet Cytogenet 1993 May;67(1):71-8 |
PMID 8504404 |
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Cytogenetic survey of sixty-one patients with preleukemic syndrome including myeloproliferative and myelodysplastic diseases |
Palka G, Spadano A, Calabrese G, Parruti G, Guanciali Franchi P, Di Sante O, Recchia A, Di Lorenzo R, Torlontano G |
Ann Genet 1990;33(4):214-8 |
PMID 2095702 |
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Therapy-related myelodysplasia and acute myeloid leukemia |
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PMID 8255096 |
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Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia |
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Blood 2009 Sep 24;114(13):2688-98 |
PMID 19641190 |
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Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia |
Safavi S, Hansson M, Karlsson K, Biloglav A, Johansson B, Paulsson K |
Haematologica 2015 Jan;100(1):55-61 |
PMID 25261097 |
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Chromosomal alterations in acute leukemia patients studied with improved culture methods |
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Cancer Res 1985 Jan;45(1):430-4 |
PMID 3855285 |
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Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping |
Veldman T, Vignon C, Schröck E, Rowley JD, Ried T |
Nat Genet 1997 Apr;15(4):406-10 |
PMID 9090389 |
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Refined chromosome analysis as an independent prognostic indicator in de novo myelodysplastic syndromes |
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Blood 1986 Jun;67(6):1721-30 |
PMID 3708158 |
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