| Disease |
Myeloid malignancies and acute lymphoblastic leukemia (ALL). |
| Etiology | Deletion of 7p as the sole abnormality occurs in disorders with myelodysplastic or myeloproliferative features and acute lymphoblastic leukemia, and may therefore affect early hematopoietic progenitor cells. |
| Epidemiology | Myeloproliferative disorders mainly: chronic myeloproliferative disorder in 9 (balanced sex ratio; 4 males and 5 females aged 53 to 79 years old, median age 63 years) (Bernstein et al., 1980; CML Yunis et al., 1986; Obeid et al., 1989; Palka et al., 1990; Rodjer et al., 1990; Ohyashiki et al., 1993; Pedersen-Bjergaard et al., 1993; Lezon-Geyda et al., 2001; Maciejewski et al., 2002) and AML in 10 patients (4 males and 6 females, aged 0 to 80 years, median age 0 years) (Bernstein et al., 1984; Testa et al., 1985; Mecucci et al., 1989; Abruzzo et al., 1992; Veldman et al., 1997; Chessells et al., 2002; Babicka et al., 2007; Blink et al., 2012). Male prevalence and prevalence of T-cell phenotype and in ALL (6 males and 2 females aged 3 to 50 years, median age 25 years) (Kaneko et al., 1989; Berger et al., 1990; Bernard et al., 2001; Berger et al., 2003; Douet-Guilbert et al., 2004; Mullighan et al., 2009; Russell et al., 2009; Safavi et al., 2015). 5 patients with myeloid malignancies had secondary disorders treated for a previous malignancy (Mecucci et al., 1989; Rodjer et al., 1990; Abruzzo et al., 1992; Pedersen-Bjergaard et al., 1993). Three patients were Down syndrome patients (Table 1).
| Chronic myeloproliferative disorders | | 1 | F/64 | CMD | 46,XX,del(7)(p11) | | 2 | M/71 | RAEB | 46,XY,del(7)(p11p22) | | 3 | F/62 | CMMoL | 46,XX,del(7)(p11) | | 4 | F/68 | RAEB | 46,XX,del(7)(p13) | | 5 | M/62 | RA | 45,XY,-10/46,XY,del(7)(p13p14) multiple myeloma, chemotherapy | | 6 | F | RA | 46,XX,del(7)(p14) | | 7 | F/63 | MDS | 46,XX,del(7)(p11) 46,XX,-7,+21 multiple myeloma, chemotherapy | | 8 | M/76 | MDS | 46,XY,del(7)(p12p15) | | 9 | M/53 | RA | 47,XY,del(7)(p13p22) | | Acute myeloid leukemia | | 10 | M/7 | AML-M2 | 46,XY,del(7)(p11) | | 11 | M/51 | AML-M1 | 46,XY,del(7)(p1?5) | | 12 | F/20 | AML-M4 | 46,XX,del(7)(p14 | | 13 | M/47 | AML-M2 | 46,XY,del(7)(p12p21) Hodgkin disease, chemotherapy, radiotherapy | | 14 | F/80 | AML-M4 | 46,XX,del(7)(p12p21) polycythemia vera, chemotherapy, radiotherapy | | 15 | F/11 | AML | 46,XX,del(7)(p12) mature B-cell neoplasm, chemotherapy | | 16 | F/57 | AML-M7 | 47,XX,del(7)(p?),+21c | | 17 | F/0 | AML-M7 | 46,XX,del(7)(p15) | | 18 | M/55 | AML-M0 | 46,XY,del(7)(p12)/46,idem,t(2;2)(q31;q35) | | 19 | F/1 | AML | 47,XX,del(7)(p11),+21c | | Acute lymphoblastic leukemia | | 20 | M/14 | T-ALL | 46,XY,del(7)(p15) | | 21 | M/25 | T-ALL | 46,XY,del(7)(p13p15) | | 22 | M/25 | T-ALL | 46,XY,del(7)(p13) | | 23 | M/29 | T-ALL | 46,XY,del(7)(p11p15) | | 24 | M/50 | T-ALL | 46,XY,del(7)(p12) | | 25 | F | ALL | 47,XX,del(7)(p13p15),+21c | | 26 | F/3 | B-ALL | 47-48,XX,+17,del(20),+21,inc/46,XX,del(7)(p11) | | 27 | M/30 | T-ALL | 46,XY,del(7)(p13) |
Abbreviations: M, male; F, female; CMD, chronic myeloproliferative disorder; RAEB, refractory anemia with excess of blasts; MDS, myelodysplastic syndrome; CMMoL, chronic myelomonocytic leukemia; RA, refractory anemia; AML-M2, acute myeloblastic leukemia with maturation; AML-M1, acute myeloblastic leukemia without maturation; AML-M4, acute myelomonocytic leukemia; AML, acute myeloid leukemia; AML-M7, acute megakaryoblastic leukemia; AML-M5, acute monoblastic leukemia; AML-M0, acute myeloblastic leukemia with minimal differentiation, ALL, acute lymphoblastic leukemia/lymphoblastic lymphoma.
1. Bernstein et al., 1980; 2. Yunis et al., 1986; 3. Obeid et al., 1989; 4. Palka et al., 1990. 5. Rodjer et al., 1990; 6. Ohyashiki et al., 1993; 7. Pedersen-Bjergaard et al., 1993; 8. Lezon et al., 2001; 9. Maciejewski et al., 2002; 10. Bernstein et al., 1984; 11. Testa et al., 1985; 12-14. Mecucci et al., 1989; 15. Abruzzo et al., 1992; 16. Veldman et al., 1997; 17. Chessells et al., 2002; 18. Babicka et al., 2007; 19. Blink et al., 2012; 20. Kaneko et al., 1989; 21. Berger et al., 1990; 22. Bernard et al., 2001; 23. Berger et al., 2003; 24. Douet-Guilbert et al., 2004; 25. Mullighan et al., 2009; 26. Russell et al., 2009; 27. Safavi et al., 2015. |
| Cytogenetics | Represents as interstitial (9 cases) or terminal deletion (18 patients) with various breakpoints. |
| Prognosis | Deletion of 7p, appears to confer increased risk of treatment failure and inferior outcome, same as it observed with monosomy 7 in myeloid malignancies. Similarly, event-free survival and survival for patients with monosomy 7 or del(7p), but not of patients with del(7q), were significantly worse in ALL patients than those lacking these abnormalities suggesting the critical region of loss may be on the p-arm (Mecucci et al., 1989; Heerema et al. 2004). |
| T-cell lymphoblastic lymphoma with eosinophilia associated with subsequent myeloid malignancy |
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| t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia |
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| Leukemia 1989 Dec;3(12):886-92 |
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| Leukemia 2001 Jun;15(6):954-62 |
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