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del(7q) in non-Hodgkin's lymphoma (NHL)

Written2001-01Antonio Cuneo, Gianluigi Castoldi
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

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Atlas_Id 2082
  del(7q) in non-Hodgkin's lymphoma (NHL) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Clinics and Pathology

Disease the frequency of 7q deletions in unseletced NHL is less than 5%; an association with splenic marginal zone B-cell lymphomas (MZBCL) was established, with a 20-30% incidence; sensitive molecular genetic studies found a 40% incidence in splenic MZBCL, as against a 7% incidence in other forms of NHL
Prognosis there may be an association of 7q- with tumor progression or transformation into a high-grade MZBCL


Cytogenetics Morphological 7q deletions or unbalanced 7q translocations in NHL usually involve a relatively large segment, usually centered around the 7q22-q32 region
Cytogenetics Molecular conventional G- or R-banded preparations detect the majority of cases; however some patients with submicroscopic deletion were detected by FISH or loss-of-heterozigosity studies

Genes involved and Proteins

Note the involved gene(s) are unknown; the minimal region of deletion in MZBCL carrying a 7q- chromosome was narrowed down to a 5cM segment defined by the D7S685 and D7S514 markers; homozygous deletion of the D7S685 was reported, suggesting that a tumor suppressor gene relevant to lymphomagenesis may be located in this region; a recurrent 7q21 translocation involving a small 3.6 Kb segment upstream of the cyclin-dependent kinase 6 gene ( CDK6), with resultant CDK6 overexpression, was described


Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations.
Corcoran MM, Mould SJ, Orchard JA, Ibbotson RE, Chapman RM, Boright AP, Platt C, Tsui LC, Scherer SW, Oscier DG
Oncogene. 1999 ; 18 (46) : 6271-6277.
PMID 10597225
Molecular cytogenetic characterization of marginal zone B-cell lymphoma: correlation with clinicopathologic findings in 14 cases.
Cuneo A, Bigoni R, Roberti MG, Milani R, Agostini P, Cavazzini F, Minotto C, De Angeli C, Bardi A, Tammiso E, Negrini M, Cavazzini P, Castoldi G
Haematologica. 2001 ; 86 (1) : 64-70.
PMID 11146573
7q31-32 allelic loss is a frequent finding in splenic marginal zone lymphoma.
Mateo M, Mollejo M, Villuendas R, Algara P, Sanchez-Beato M, Martínez P, Piris MA
The American journal of pathology. 1999 ; 154 (5) : 1583-1589.
PMID 10329610
Cytogenetic studies in splenic lymphoma with villous lymphocytes.
Oscier DG, Matutes E, Gardiner A, Glide S, Mould S, Brito-Babapulle V, Ellis J, Catovsky D
British journal of haematology. 1993 ; 85 (3) : 487-491.
PMID 8136270


This paper should be referenced as such :
Cuneo, A ; Castoldi, GL
del(7q) in non-Hodgkin's lymphoma (NHL)
Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):52-53.
Free journal version : [ pdf ]   [ DOI ]
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