| Written | 2001-01 | Antonio Cuneo, Gianluigi Castoldi |
| Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| Atlas_Id | 2082 |
 | |
| del(7q) in non-Hodgkin's lymphoma (NHL) G- banding - Courtesy Melanie Zenger and Claudia Haferlach. | |
| Clinics and Pathology |
| Disease | the frequency of 7q deletions in unseletced NHL is less than 5%; an association with splenic marginal zone B-cell lymphomas (MZBCL) was established, with a 20-30% incidence; sensitive molecular genetic studies found a 40% incidence in splenic MZBCL, as against a 7% incidence in other forms of NHL |
| Prognosis | there may be an association of 7q- with tumor progression or transformation into a high-grade MZBCL |
| Cytogenetics |
| Cytogenetics Morphological | 7q deletions or unbalanced 7q translocations in NHL usually involve a relatively large segment, usually centered around the 7q22-q32 region |
| Cytogenetics Molecular | conventional G- or R-banded preparations detect the majority of cases; however some patients with submicroscopic deletion were detected by FISH or loss-of-heterozigosity studies |
| Genes involved and Proteins |
| Note | the involved gene(s) are unknown; the minimal region of deletion in MZBCL carrying a 7q- chromosome was narrowed down to a 5cM segment defined by the D7S685 and D7S514 markers; homozygous deletion of the D7S685 was reported, suggesting that a tumor suppressor gene relevant to lymphomagenesis may be located in this region; a recurrent 7q21 translocation involving a small 3.6 Kb segment upstream of the cyclin-dependent kinase 6 gene ( CDK6), with resultant CDK6 overexpression, was described |
| Bibliography |
| Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations. |
| Corcoran MM, Mould SJ, Orchard JA, Ibbotson RE, Chapman RM, Boright AP, Platt C, Tsui LC, Scherer SW, Oscier DG |
| Oncogene. 1999 ; 18 (46) : 6271-6277. |
| PMID 10597225 |
| Molecular cytogenetic characterization of marginal zone B-cell lymphoma: correlation with clinicopathologic findings in 14 cases. |
| Cuneo A, Bigoni R, Roberti MG, Milani R, Agostini P, Cavazzini F, Minotto C, De Angeli C, Bardi A, Tammiso E, Negrini M, Cavazzini P, Castoldi G |
| Haematologica. 2001 ; 86 (1) : 64-70. |
| PMID 11146573 |
| 7q31-32 allelic loss is a frequent finding in splenic marginal zone lymphoma. |
| Mateo M, Mollejo M, Villuendas R, Algara P, Sanchez-Beato M, Martínez P, Piris MA |
| The American journal of pathology. 1999 ; 154 (5) : 1583-1589. |
| PMID 10329610 |
| Cytogenetic studies in splenic lymphoma with villous lymphocytes. |
| Oscier DG, Matutes E, Gardiner A, Glide S, Mould S, Brito-Babapulle V, Ellis J, Catovsky D |
| British journal of haematology. 1993 ; 85 (3) : 487-491. |
| PMID 8136270 |
| Citation |
| This paper should be referenced as such : |
| Cuneo, A ; Castoldi, GL |
| del(7q) in non-Hodgkin's lymphoma (NHL) |
| Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):52-53. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/del7qNHLID2082.html |
| External links |
| arrayMap (UZH-SIB Zurich) | [select an item] |
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| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Aug 12 16:59:04 CEST 2019 |
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