Written | 2001-01 | Antonio Cuneo, Gianluigi Castoldi |
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy |
Identity |
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
Atlas_Id | 2082 |
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del(7q) in non-Hodgkin's lymphoma (NHL) G- banding - Courtesy Melanie Zenger and Claudia Haferlach. | |
Clinics and Pathology |
Disease | the frequency of 7q deletions in unseletced NHL is less than 5%; an association with splenic marginal zone B-cell lymphomas (MZBCL) was established, with a 20-30% incidence; sensitive molecular genetic studies found a 40% incidence in splenic MZBCL, as against a 7% incidence in other forms of NHL |
Prognosis | there may be an association of 7q- with tumor progression or transformation into a high-grade MZBCL |
Cytogenetics |
Cytogenetics Morphological | 7q deletions or unbalanced 7q translocations in NHL usually involve a relatively large segment, usually centered around the 7q22-q32 region |
Cytogenetics Molecular | conventional G- or R-banded preparations detect the majority of cases; however some patients with submicroscopic deletion were detected by FISH or loss-of-heterozigosity studies |
Genes involved and Proteins |
Note | the involved gene(s) are unknown; the minimal region of deletion in MZBCL carrying a 7q- chromosome was narrowed down to a 5cM segment defined by the D7S685 and D7S514 markers; homozygous deletion of the D7S685 was reported, suggesting that a tumor suppressor gene relevant to lymphomagenesis may be located in this region; a recurrent 7q21 translocation involving a small 3.6 Kb segment upstream of the cyclin-dependent kinase 6 gene ( CDK6), with resultant CDK6 overexpression, was described |
Bibliography |
Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations. |
Corcoran MM, Mould SJ, Orchard JA, Ibbotson RE, Chapman RM, Boright AP, Platt C, Tsui LC, Scherer SW, Oscier DG |
Oncogene. 1999 ; 18 (46) : 6271-6277. |
PMID 10597225 |
Molecular cytogenetic characterization of marginal zone B-cell lymphoma: correlation with clinicopathologic findings in 14 cases. |
Cuneo A, Bigoni R, Roberti MG, Milani R, Agostini P, Cavazzini F, Minotto C, De Angeli C, Bardi A, Tammiso E, Negrini M, Cavazzini P, Castoldi G |
Haematologica. 2001 ; 86 (1) : 64-70. |
PMID 11146573 |
7q31-32 allelic loss is a frequent finding in splenic marginal zone lymphoma. |
Mateo M, Mollejo M, Villuendas R, Algara P, Sanchez-Beato M, Martínez P, Piris MA |
The American journal of pathology. 1999 ; 154 (5) : 1583-1589. |
PMID 10329610 |
Cytogenetic studies in splenic lymphoma with villous lymphocytes. |
Oscier DG, Matutes E, Gardiner A, Glide S, Mould S, Brito-Babapulle V, Ellis J, Catovsky D |
British journal of haematology. 1993 ; 85 (3) : 487-491. |
PMID 8136270 |
Citation |
This paper should be referenced as such : |
Cuneo, A ; Castoldi, GL |
del(7q) in non-Hodgkin's lymphoma (NHL) |
Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):52-53. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Anomalies/del7qNHLID2082.html |
External links |
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