Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

der(15)t(1;15)(q11-12;p11-13) and der(15)t(1;15)(q21-25;p10-13)

Written2017-11Adriana Zamecnikova
Kuwait Cancer Control Center, Kuwait annaadria@yahoo.com

Abstract Unbalanced 1q translocations leading to complete or partial trisomies of the long arm of chromosome 1 have been widely reported in both lymphoid and myeloid neoplasms. Chromosomal translocations between the long arm of chromosome 1 and the acrocentric chromosome 15 are mostly secondary events representing clonal evolution.

Keywords Gain of 1q, unbalanced translocations, acrocentric chromosomes, gene overexpression.

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9671/3 Lymphoplasmacytic lymphoma
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9687/3 Burkitt lymphoma
ICD-Morpho 9827/3 Adult T-cell leukaemia/lymphoma
ICD-Morpho 9673/3 Mantle cell lymphoma
ICD-Morpho 9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS; Primary DLBCL of the CNS; Primary cutaneous DLBCL, leg type; EBV positive DLBCL of the elderly; DLBCL associated with chronic inflammation; B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
ICD-Morpho 9690/3 Follicular lymphoma; Paediatric follicular lymphoma
ICD-Morpho 9732/3 Plasma cell myeloma / Multiple myeloma
Atlas_Id 1811
 
  Figure 1. Partial karyotypes with der(15)t(1;15)(q11;p11-13).
 
  Figure 2. Fluorescence in situ hybridization with LSI 1p36/1q25 probe (Vysis, Abott Molecular, US) showing the extra green signal of 1q25 on der(15) chromosome (A). Hybridization with LSI PML/RARA probe revealing the red signal for PML located on der(15) chromosome (B).

Clinics and Pathology

Disease Chronic and acute myeloid malignancies, B-cell acute lymphoblastic leukemia (ALL), multiple myeloma (MM) and lymphomas.
Phenotype / cell stem origin
Etiology Patients with der(15)t(1;15)(q11;p11-13) were diagnosed mainly with myeloid malignancies (10 patients): 1 polycythemia vera (PV) (Sanford et al., 2015), 5 myelodysplastic syndromes (MDS) (Mecucci et al., 1986; Mascarello et al., 1989; Jotterand-Bellomo et al., 1990; Najfeld et al., 1995) and 5 patients were diagnosed with acute myeloid leukemia (AML) (Andrieux et al., 2006; Farag et al., 2006; Poppe et al., 2006; Liu et al., 2007; Manola et al., 2008). In addition, there was 1 female with non neoplastic disorder (aplastic anemia) (Kim et al., 2010). Acute lymphoblastic leukemia was diagnosed in 7 (Raimondi et al., 1990; Heerema et al., 1999; Rafi et al., 2000; Boomer et al., 2001; Wan et al., 2004; Wetzler et al., 2004; Coyaud et al., 2010) and multiple myeloma in 3 (Calasanz et al., 1997; Rajkumar et al., 1999; Smadja et., al 2001). 7 patients has various B-cell lymphomas: 1 mature B-cell neoplasm (MBCL), 3 follicular lymphoma (FL) (Horsman et al., 2001; Le Baccon et al., 2001; Narayan et al., 2013), 2 diffuse large B-cell lymphoma (DLBL) (Fan & Rizkalla., 2003; Havelange et al., 2013) and 1 mantle cell lymphoma (MCL) (Fan & Rizkalla., 2003) (Table 1).
Patients with der(15)t(1;15)(q21-25;p10-13) were diagnosed with lymphoproliferative malignancies (10 patients), among them acute lymphoblastic leukemia in 3 (Strefford et al., 2007; Schmiegelow et al., 2012; Safavi et al., 2015) and various, mainly B-cell lymphomas in 9: 1 adult T-cell lymphoma/leukemia (HTLV-1+) (ATLL) (Kamada et al., 1992), 4 diffuse large B-cell lymphomas (DLBCL) (Sandlund et al., 1994; Miura et al., 1996; Aamot et al., 2005; Zhang et al., 2009), 1 lymphoplasmacytic lymphoma (LPL) (Khokhar et al., 1995), 1 Burkitt lymphoma/leukemia (BL) (Silva et al., 2002) and 2 follicular lymphomas (FL) (Lestou et al., 2003; Keller et al., 2006). Sporadic cases of other malignancies: 1 acute myeloid leukemia (AML) (Olsson et al., 2016) and 1 multiple myeloma (MM) (Nakano et al., 2005).
Table 1. Clinical and karyotypic data of patients with der(15)t(1;15)(q11-12;p11-13).
 Sex/ AgeDiseaseKaryotype
NON NEOPLASTIC DISORDER
1F/45AA46,XX,der(15)t(1;15)(q12;p11)
CHRONIC MYELOPROLIFERATIVE DISORDERS
2M/47RARS46,XY,del(5)(q14q32),der(15)t(1;15)(q12;p11),del(20)(q11)
3M/53RARS46,XY,der(15)t(1;15)(q12;p11)/47,XY,+8
4F/15RA46,XX,qdp(3)(q21q27),der(15)t(1;15)(q11;p11)
5F/41RA46,XX,der(15)t(1;15)(q12;p11)
6F/56RAEB47,XX,+8,del(10)(p12),der(22)t(1;22)(q11;p13)/48,XX,+8,del(10),der(15)t(1;15)(q11;p13),+mar/47,XX,+der(8)t(1;8)(q11;p21)
7F/67PV47,XX,+8,der(17)t(1;17)(q11;p13),del(20)(q13)/48,XX,+8,der(15)t(1;15)(q11;p11),+der(15)t(1;15)(q11;p11),del(20)(q13)
ACUTE MYELOID LEUEMIA
8F/65AML-M546,XX,add(6)(p12),der(12)t(12;?19)(p13;?p12) or der(12)t(12;?19)(p13;q12),del(13)(q21q31),der(15)t(1;15) (q11-12;p12),add(21)(q22)/46,idem,-16,+mar
9F/62AML46,XX,der(15)t(1;15)(q11;p13)
10F/74AML-M249,XX,-1,del(3)(q24),t(3;22)(q26;q11),add(6)(p23),+7,del(8)(q24),add(9)(p22),add(12)(q24),-14,add(14)(q32),der(15)t(1;15)(q11;p11),del(17)(p11),add(18)(q21),add(19)(q13),+r,+3mar
11M/36AML58,XY,-X,-1,-3,-4,-5,+6,-7,-9,-10,-12,der(15)t(1;15)(q12;p11),-16,-17,-18,-21/58,idem,-der(15),der(21)t(1;21)(q12;p11)/47,XY,+8
12F/28AML-M146,XX,+1,der(1;7)(q10;p10)/46,XX,+1,dic(1;11)(p11;q25)/46,XX,t(1;6)(p32;q25-27),der(7)t(7;12)(q11-22;q13-15), der(12)t(1;12)(q11-12;q13-15)/46,XX,der(15)t(1;15)(q11;p11)s
ACUTE LYMPHOBLASTIC LEUKEMIA
13M B- ALL49,XY,+Y,-6,+10,der(12)t(6;12)(q21;p13),der(19)t(1;19)(q23;p13),+21,+21/49,XY,+Y,+7,der(15)t(1;15)(q11;p11), der(19),+21/50,XY,+7,+17,der(19),+20,+21
14M/0ALL46,XY,t(1;19)(q23;p13)/46,idem,der(Y)t(Y;1)(q12;q12)/46,idem,der(15)t(1;15)(q12;p11)/46,idem,der(22)t(1;22)(q12;p11)
15M/13B-ALL45,XY,add(3)(q27),del(8)(p22),t(8;22)(q24;q11),add(9)(p24),-10,t(12;21)(p13;q22),der(15)t(1;15)(q11;p11), der(22) t(1;22)(q11;p11)
16FALL46,XX,t(1;19)(q23;p13),der(15)t(1;15)(q12;p1?2)
17M/50B-ALL45,XY,der(9)t(9;22)(q34;q11),-10,der(11)t(1;11)(q12;q25),+14,der(14;22)t(14;20)(p13;p13)t(9;22),der(15)t(1;15)(q12;p13),der(19)t(1;19)(q12;p13),der(20)t(1;20)(q12;p13),-21
18MALL46,XY,t(9;22)(q34;q11),der(15)t(1;15)(q11;p11)
19M/35B-ALL46,XY,t(1;19)(q23;p13),der(15)t(1;15)(q12;p11),der(18)t(1;18)(q12;p11)/46,idem,del(9)(p21)
MULTIPLE MYELOMA
20FMM46,XX,t(11;14)(q13;q32),der(15)t(1;15)(q12;p11)
21F/44MM41-43,XX,add(1)(p13),trp(1)(p11q25),add(5)(q11),der(15)t(1;15)(q12;p13),+mar
22FMM44,XX,-1,der(8)t(1;8)(p11-12;q24),t(11;14)(q13;q32),del(14)(q21q32),der(15)t(1;15)(q12;p11),add(16)(q10),der(18) t(11;18)(q13;p11)ins(18;?1)(p11;?)ins(18;14)(p11;q32q32),-22,+mar
NON HODGKIN LYMPHOMA
23F/65 MBCL49,X,t(X;1)(p2?1;p3?1),+5,del(9)(q12q22),t(11;18;11)(p15;q21;q23),+13,del(13)(q12q14)x2,add(14)(q32), der(15) t(1;15)(q11;p11),+der(18)t(11;18)(p15;q21)/48,X,t(X;1),+11,del(13),add(14),der(15),+mar  LN
24F/57 FL  46,XX,t(14;18)(q32;q21),der(15)t(1;15)(q11;p11) LN
25F/81 FL 44,XX,+X,t(1;2)(q25;q37),dic(9;?22)(q21;p11),add(10)(p15),add(11)(p13),del(12)(?q14?q24),-13,del(14)(q24q32),der(14)add(14)(p11)t(14;18)(q32;q21),-15,der(15)t(1;15)(q12;p11),-16,-17,-18,del(20)(q11),-21,+3mar LN
26MMCL 43-44,XY,del(1)(p12p31),der(1)t(1;21)(p11;q11),der(10)t(10;22)(p13;q11),der(11)t(11;14)(q13;q32),der(14)t(11;14) del(11)(q23),der(15)t(1;15)(q12;p11),-21,-2 LN
27FDLBL 45,X,-X,der(2)t(2;3)(q31;p?),del(3)(p13p23),-4,del(6)(q13),+7,del(10)(q25),ins(10;9)(q11;q13q22) or ins(10;9) (q11;q22q34),del(13)(q12q14),der(14)t(3;14)(p?;p11),t(14;18)(q32;q21),der(15)t(1;15)(q12;p11),der(16)t(16;17) (q12;q21) LN
28F/14 DLBCL46,X,-X,der(X)t(X;4)(p21;q21),der(X)t(X;10;4)(p21;?;q12),der(3)t(3;18)(q11;q21),dup(3)(q13q24),del(4)(q12), der(4)t(X;4)(?;p16),t(8;22)(q24;q11),der(9)t(3;9)(p13;p21),t(9;20)(q10;p10),der(10)t(3;10)(?;q11),dup(11)(q23q13),der(11)dup(11)(q23q13)t(1;11)(?;q25),der(11)dup(11)(q23q13)t(3;11)(?;q25),der(11)dup(11)(q23q13)t(7;11)(?;q25),dup(11)(q23q13),trp(13)(q22q32),der(14)t(X;14)(q13;q24),der(15)t(1;15)(q11;p11),der(16)t(1;16)(p2?;q1?),der(17)t(X;17)(q21;p11),der(17)t(X;17;6)(p11;p11q25;?),der(18)t(4;18)(?;q23),der(18)t(6;18)(?;q23),dup(18)(q11q23),der(22)t(16;22)(?;q1?3) exudate
29F/65 FL90-96,XXXX,+X,+X,ins(1;?)(q21;?)x2,add(1)(p22),del(3)(q11),i(3)(p10),-4,der(15)t(1;15)(q11;p11)x2,i(17)(q10) x2,+21,+21,+1-6mar LN

Abbreviations: M, male; F, female; AA, Aplastic anemia, RARS, Refractory anemia with ringed sideroblasts; RA, Refractory anemia; RAEB, Refractory anemia with excess of blasts; PV, Polycythemia vera; AML-M5, Acute monoblastic leukemia with differentiation; AML, Acute myeloid leukemia; AML-M2, Acute myeloblastic leukemia with maturation; AML-M1, Acute myeloblastic leukemia without maturation; ALL,  Acute lymphoblastic leukemia; MM, Multiple myeloma; MBCN, Mature B-cell neoplasm; LN, lymph node, FL,  Follicular lymphoma, MCL, Mantle cell lymphoma; DLBCL, Diffuse large B-cell lymphoma.
1. Kim et al., 2010; 2-3. Mecucci et al., 1986; 4. Mascarello et al., 1989; 5. Jotterand-Bellomo et al., 1990; 6. Najfeld et al., 1995; 7. Sanford et al., 2015 ; 8. Andrieux et al., 2006; 9. Farag et al., 2006; 10. Poppe et al., 2006; 11. Liu et al., 2007; 12. Manola et al., 2008; 13. Raimondi et al., 1990; 14. Heerema et al., 1999; 15. Rafi et al., 2000; 16. Boomer et al., 2001; 17. Wan et al., 2004; 18. Wetzler et al., 2004; 19. Coyaud et al., 2010; 20. Calasanz et al., 1997; 21. Rajkumar et al., 1999; 22. Smadja et al., 2001; 23. Kobayashi et al., 1993; 24. Horsman et al., 2001; 25. Le Baccon et al., 2001; 26-27. Fan & Rizkalla 2003; 28. Havelange et al., 2013; 29. Narayan et al., 2013.
Table 2. Clinical and karyotypic data of patients with der(15)t(1;15)(q21-25;p10-13).
 SEX/AGEDISEASEKARYOTYPE
ACUTE MYELOID LEUKEMIA
1M/11 AML46,XY,add(4)(p16),der(15)t(1;15)(q25;p12)/46,idem,del(5)(q22),der(8)t(5;8)(q31;q22)
ACUTE LYMPHOBLASTIC LEUEMIA
2M/6ALL46,XY,der(15)t(1;15)(q23;p11)
3M/9 B-ALL46,XY,t(1;19)(q23;p13),der(14)t(1;14)(q21;p1?2),der(15)t(1;15)(q21;p1?2),der(22)t(1;22)(q21;p1?2)
4F/22 B-ALL46,XX,der(19)t(1;19)(q23;p13)/46,idem,der(15)t(1;15)(q21;p11)
MULTIPLE MYELOMA
5F/69 MM46,XX,der(15)t(1;15)(q21;p13)
NON-HODGKIN'S LYMPHOMA
6F/ 62 ATCL (HTLV-1+) 47,X,-X,add(1)(p12),add(3)(p25),+add(3)(q21),der(11)t(1;11)(p12;q14),add(14)(p11),der(15)t(1;15)(q21;p11),der(16)t(11;16)(q14;q13),-18,-22,+3mar
7M/10 DLBCL88-93,XYY,add(X)(q2?6),der(2)add(2)(p23)add(2)(q23),t(2;5)(p23;q35),add(3)(q29),add(3)(q27),add(4) (q22),del(6)(q21q23)x2,add(9)(p24),add(11)(q23)x2,der(15)t(1;15)(q21;p13),der(15)t(1;15)(q21;p13)t(1;1)(q42;q32),add(17)(p13),+mar,inc
8M/49 LPL  LN46,XY,t(1;4)(q21;q32),der(3)t(3;3)(p25;q21)dup(3)(q21q29),t(12;14)(q13;q32),der(14)t(1;14)(q21;q32),der(15)t(1;15)(q21;p12)
9M/62 DLBCL45,X,-Y,t(3;6)(q27;p21),der(6)t(6;8)(q27;q22),der(15)t(1;15)(q21;p13),del(16)(q22)
10F/11 BL46,XX,t(8;14)(q24;q32),der(15)t(1;15)(q21;p13)
11F/ FL LN47-49,XX,+7,+der(9)del(9)(p13)t(4;9)(?p14;q33),dup(12)(q13q22)x2,+14,der(15)t(1;15)(q23;p11),t(18;22)(q21;q11),+21,+der(21),+der(22),+der(22)t(3;22)(?q27;q11)
12MDLBCL LN52,XY,+Y,+der(3)t(3;9)(p11;p21)del(3)(q21),+7,+9,der(9)t(3;9)(q21;p21)x2,t(14;22)(q32;q11),der(15) t(1;5)(q21;p11),del(16)(p13),i(17)(q10),+18,+mar>
13M/79 FL  LN48,XY,+X,del(1)(p13),add(2)(p25),inv(3)(p24q27),t(8;14)(q24;q32),dup(12)(q12q24),t(14;18)(q32;q21),   -15,der(15)t(1;15)(q21;p10),add(16)(q24)
14M/32 DLBCL LN85-87,XXY,-1,i(1)(q10),-2,add(2)(p23),dic(3;7)(p23;q11),del(4)(q21),del(5)(q13),+der(5)t(3;5)(p13;q22), del(7)(q11),-9,add(9)(q34),t(9;14)(q13;q32),-10,-11,add(11)(p14),i(11)(q10),-12,der(13;13)(q10;q10),-14, -15,der(15)t(1;15)(q21;p13),-16,-16,-17,-17,-22,inc

Abbreviations: M, male; F, female; AML, acute myeloid leukemia; ALL, acute lymphoblastic leukemia; MM, multiple myeloma;. ATLL, adult T-cell lymphoma/leukemia; DLBCL diffuse large B-cell lymphoma; LPL, lymphoplasmacytic lymphoma; LN, lymph node; BL, Burkitt lymphoma/leukemia; FL, follicular lymphoma.
1. Olsson et al., 2016; 2. Strefford et al., 2007; 3. Schmiegelow et al., 2012; 4. Safavi et al., 2015; 5. Nakano et al., 2005; 6. Kamada et al., 1992; 7. Sandlund et al., 1994; 8. Khokhar et al., 1995; 9. Miura et al., 1996; 10. Silva et al., 2002; 11. Lestou et al., 2003; 12. Aamot et al., 2005; 13. Keller et al., 2006; 14. Zhang et al., 2009.
Epidemiology The centromeric 1q11-12 translocation was reported at least in 29 patients (10 males and 19 females aged 0 to 81 years; median 47 years); among them there was 1 infant and 3 pediatric patients aged 13 to 15 years. Patients with 1q21-25 were less frequent and have been reported in 9 males and 5 females aged 6 to 79 years (median 22 years), 5 of them were children aged 6 to 11 years (4 males and 1 female).
Prognosis In patients with complex karyotypes the appearance of the abnormality is associated with advanced disease, therapy resistance and unfavorable prognosis.

Cytogenetics

Note To exclude the presence of dic(1;15)(p10-11;p10-11) or dic(1;15)(q10 11;q10-11) fluorescence in situ hybridization with centromere-specific probes for both chromosomes is recommended.
Cytogenetics Morphological der(15)t(1;15)(q11-2;p11-13) was found as a sole anomaly in 2 MDS (Mecucci et al., 1986; Jotterand-Bellomo et al., 1990), 1 AML (Farag et al., 2006) and in the aplastic anemia patient (Kim et al., 2010). Found in association with del(5)(q14q32) and del(20)(q11) in 1 MDS (Mecucci et al., 1986) and +8 and del(20)(q13) in PV (Sanford et al., 2015). Associated with der(19)t(1;19)(q23;p13)/t(1;19)(q23;p13) in 4 out of 7 ALL patients (Raimondi et al., 1990; Heerema et al., 1999; Boomer et al., 2001; Coyaud et al., 2010), t(9;22)(q34;q11) in 2 (Wan et al., 2004; Wetzler et al., 2004) and t(8;22)(q24;q11) in 1 (Rafi et al 2000). Found with t(11;14)(q13;q32) in 2 out of 3 MM (Calasanz et al., 1997; Smadja et al., 2001) and 1 patient with MCL (Fan & Rizkalla 2003), 14q32/ t(14;18)(q32;q21) in 4 lymphomas (Kobayashi et al., 1993; Horsman et al., 2001; Le Baccon et al., 2001; Fan & Rizkalla 2003) and highly complex karyotypes in the remaining patients.
In the group of patients with 1q21-25 breakpoints, it was a sole anomaly in 1 ALL (Strefford et al., 2007) and 1 MM (Nakano et al., 2005) and found with t(1;19)(q23;p13)/der(19)t(1;19)(q23;p13) in the remaining 2 ALL patients (Schmiegelow et al., 2012; Safavi et al., 2015); found as a part of highly complex karyotypes in lymphoma patients.

Result of the chromosomal anomaly

Fusion Protein
Oncogenesis Unbalanced 1q translocations with an acrocentric recipient chromosome 15 result in 1q trisomy. The main consequence of these rearrangements is genomic imbalance resulting from the presence of an extra copy of the long arm of chromosome 1, leading to overexpression of several genes, likely implicated in neoplastic processes by a gene dosage effect. They presumably occur as a secondary aberration in addition to well-known primary abnormalities, therefore representing clonal evolution preceding or accompanying disease progression.
  

Bibliography

t(14;22)(q32;q11) in non-Hodgkin lymphoma and myeloid leukaemia: molecular cytogenetic investigations
Aamot HV, Bjørnslett M, Delabie J, Heim S
Br J Haematol 2005 Sep;130(6):845-51
PMID 16156854
 
Cryptic 6p21
Andrieux J, Geffroy S, Bilhou-Nabera C, Dupriez B, Demory JL, Bauters F, Laï JL, Dastugue N
3 duplications and triplication involving HMGA1 partially masked by add 6p in four cases of myelodysplasia Cancer Genet Cytogenet
PMID 16364769
 
Detection of E2A translocations in leukemias via fluorescence in situ hybridization
Boomer T, Varella-Garcia M, McGavran L, Meltesen L, Olsen AS, Hunger SP
Leukemia 2001 Jan;15(1):95-102
PMID 11243406
 
Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations
Calasanz MJ, Cigudosa JC, Odero MD, Ferreira C, Ardanaz MT, Fraile A, Carrasco JL, Solé F, Cuesta B, Gullón A
Genes Chromosomes Cancer 1997 Feb;18(2):84-93
PMID 9115968
 
Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461
Cancer and Leukemia Group B 8461, Farag SS, Archer KJ, Mrózek K, Ruppert AS, Carroll AJ, Vardiman JW, Pettenati MJ, Baer MR, Qumsiyeh MB, Koduru PR, Ning Y, Mayer RJ, Stone RM, Larson RA, Bloomfield CD
Blood 2006 Jul 1;108(1):63-73
PMID 16522815
 
Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study
Coyaud E, Struski S, Prade N, Familiades J, Eichner R, Quelen C, Bousquet M, Mugneret F, Talmant P, Pages MP, Lefebvre C, Penther D, Lippert E, Nadal N, Taviaux S, Poppe B, Luquet I, Baranger L, Eclache V, Radford I, Barin C, Mozziconacci MJ, Lafage-Pochitaloff M, Antoine-Poirel H, Charrin C, Perot C, Terre C, Brousset P, Dastugue N, Broccardo C
Blood 2010 Apr 15;115(15):3089-97
PMID 20160164
 
Comprehensive cytogenetic analysis including multicolor spectral karyotyping and interphase fluorescence in situ hybridization in lymphoma diagnosis
Fan YS, Rizkalla K
a summary of 154 cases Cancer Genet Cytogenet
PMID 12742158
 
Patterns of genomic aberrations suggest that Burkitt lymphomas with complex karyotype are distinct from other aggressive B-cell lymphomas with MYC rearrangement
Havelange V, Ameye G, Théate I, Callet-Bauchu E, Mugneret F, Michaux L, Dastugue N, Penther D, Barin C, Collonge-Rame MA, Baranger L, Terré C, Nadal N, Lippert E, Laï JL, Cabrol C, Tigaud I, Herens C, Hagemeijer A, Raphael M, Libouton JM, Poirel HA; GFCH (Groupe Francophone de Cytogénétique Hématologique)
Genes Chromosomes Cancer 2013 Jan;52(1):81-92
PMID 23012230
 
Cytogenetic studies of infant acute lymphoblastic leukemia: poor prognosis of infants with t(4;11) - a report of the Children's Cancer Group
Heerema NA, Sather HN, Ge J, Arthur DC, Hilden JM, Trigg ME, Reaman GH
Leukemia 1999 May;13(5):679-86
PMID 10374870
 
Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18)
Horsman DE, Connors JM, Pantzar T, Gascoyne RD
Genes Chromosomes Cancer 2001 Apr;30(4):375-82
PMID 11241790
 
Cytogenetic analysis of 54 cases of myelodysplastic syndrome
Jotterand-Bellomo M, Parlier V, Schmidt PM, Beris P
Cancer Genet Cytogenet 1990 Jun;46(2):157-72
PMID 2340487
 
Chromosome abnormalities in adult T-cell leukemia/lymphoma: a karyotype review committee report
Kamada N, Sakurai M, Miyamoto K, Sanada I, Sadamori N, Fukuhara S, Abe S, Shiraishi Y, Abe T, Kaneko Y, et al
Cancer Res 1992 Mar 15;52(6):1481-93
PMID 1540956
 
Intrachromosomal rearrangement of chromosome 3q27: an under recognized mechanism of BCL6 translocation in B-cell non-Hodgkin lymphoma
Keller CE, Nandula S, Vakiani E, Alobeid B, Murty VV, Bhagat G
Hum Pathol 2006 Aug;37(8):1093-9
PMID 16867873
 
Cytogenetic abnormalities in the leukemic phase of non-Hodgkin lymphoma
Khokhar MT, Brito-Babapulle V, Matutes E, Catovsky D
Cancer Genet Cytogenet 1995 Aug;83(1):18-24
PMID 7656198
 
The characteristics and clinical outcome of adult patients with aplastic anemia and abnormal cytogenetics at diagnosis
Kim SY, Lee JW, Lee SE, Cho BS, Kim M, Eom KS, Kim YJ, Kim HJ, Lee S, Min CK, Cho SG, Kim DW, Han K, Min WS
Genes Chromosomes Cancer 2010 Sep;49(9):844-50
PMID 20540166
 
Heterogeneity of breakpoints of 11q23 rearrangements in hematologic malignancies identified with fluorescence in situ hybridization
Kobayashi H, Espinosa R 3rd, Thirman MJ, Gill HJ, Fernald AA, Diaz MO, Le Beau MM, Rowley JD
Blood 1993 Jul 15;82(2):547-51
PMID 8329710
 
Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma
Le Baccon P, Leroux D, Dascalescu C, Duley S, Marais D, Esmenjaud E, Sotto JJ, Callanan M
Genes Chromosomes Cancer 2001 Nov;32(3):250-64
PMID 11579465
 
Multicolour fluorescence in situ hybridization analysis of t(14;18)-positive follicular lymphoma and correlation with gene expression data and clinical outcome
Lestou VS, Gascoyne RD, Sehn L, Ludkovski O, Chhanabhai M, Klasa RJ, Husson H, Freedman AS, Connors JM, Horsman DE
Br J Haematol 2003 Sep;122(5):745-59
PMID 12930384
 
Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation
Liu TX, Becker MW, Jelinek J, Wu WS, Deng M, Mikhalkevich N, Hsu K, Bloomfield CD, Stone RM, DeAngelo DJ, Galinsky IA, Issa JP, Clarke MF, Look AT
Nat Med 2007 Jan;13(1):78-83
PMID 17159988
 
Jumping translocations in hematological malignancies: a cytogenetic study of five cases
Manola KN, Georgakakos VN, Stavropoulou C, Spyridonidis A, Angelopoulou MK, Vlachadami I, Katsigiannis A, Roussou P, Pantelias GE, Sambani C
Cancer Genet Cytogenet 2008 Dec;187(2):85-94
PMID 19027489
 
A dysmorphic child with myelodysplasia characterized by a duplication of 1q and multiple duplications of 3q
Mascarello JT, Osborn C, Kadota RP
Cancer Genet Cytogenet 1989 Mar;38(1):9-12
PMID 2713819
 
An identical translocation between chromosome 1 and 15 in two patients with myelodysplastic syndromes
Mecucci C, Tricot G, Boogaerts M, Van den Berghe H
Br J Haematol 1986 Mar;62(3):439-45
PMID 3954964
 
A new non-random chromosomal translocation t(3;6)(q27;p21
Miura I, Ohshima A, Takahashi N, Hashimoto K, Nimura T, Utsumi S, Saito M, Miki T, Hirosawa S, Miura AB
3) associated with BCL6 rearrangement in two patients with non-Hodgkin's lymphoma Int J Hematol
PMID 8923787
 
Jumping translocations in leukemia
Najfeld V, Hauschildt B, Scalise A, Gattani A, Patel R, Ambinder EP, Silverman LR
Leukemia 1995 Apr;9(4):634-9
PMID 7723397
 
The unbalanced chromosomal translocation der(15)t(1;15)(q21;p13) in multiple myeloma
Nakano S, Namura K, Uchida R, Fuchida S, Okano A, Okamoto M, Shimazaki C
Int J Hematol 2005 Jun;81(5):437-8
PMID 16158828
 
PCDH10 promoter hypermethylation is frequent in most histologic subtypes of mature lymphoid malignancies and occurs early in lymphomagenesis
Narayan G, Xie D, Freddy AJ, Ishdorj G, Do C, Satwani P, Liyanage H, Clark L, Kisselev S, Nandula SV, Scotto L, Alobeid B, Savage D, Tycko B, O'Connor OA, Bhagat G, Murty VV
Genes Chromosomes Cancer 2013 Nov;52(11):1030-41
PMID 23929756
 
The genetic landscape of paediatric de novo acute myeloid leukaemia as defined by single nucleotide polymorphism array and exon sequencing of 100 candidate genes
Olsson L, Zettermark S, Biloglav A, Castor A, Behrendtz M, Forestier E, Paulsson K, Johansson B
Br J Haematol 2016 Jul;174(2):292-301
PMID 27022003
 
EVI1 is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements
Poppe B, Dastugue N, Vandesompele J, Cauwelier B, De Smet B, Yigit N, De Paepe A, Cervera J, Recher C, De Mas V, Hagemeijer A, Speleman F
Genes Chromosomes Cancer 2006 Apr;45(4):349-56
PMID 16342172
 
ETV6/CBFA2 fusions in childhood B-cell precursor acute lymphoblastic leukemia with myeloid markers
Rafi SK, El Gebaly H, Qumsiyeh MB
Diagn Mol Pathol 2000 Dec;9(4):184-9
PMID 11129441
 
Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19)
Raimondi SC, Behm FG, Roberson PK, Williams DL, Pui CH, Crist WM, Look AT, Rivera GK
J Clin Oncol 1990 Aug;8(8):1380-8
PMID 2380759
 
Cytogenetic abnormalities correlate with the plasma cell labeling index and extent of bone marrow involvement in myeloma
Rajkumar SV, Fonseca R, Dewald GW, Therneau TM, Lacy MQ, Kyle RA, Greipp PR, Gertz MA
Cancer Genet Cytogenet 1999 Aug;113(1):73-7
PMID 10459351
 
Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia
Safavi S, Hansson M, Karlsson K, Biloglav A, Johansson B, Paulsson K
Haematologica 2015 Jan;100(1):55-61
PMID 25261097
 
Clinicopathologic features and treatment outcome of children with large-cell lymphoma and the t(2;5)(p23;q35)
Sandlund JT, Pui CH, Roberts WM, Santana VM, Morris SW, Berard CW, Hutchison RE, Ribeiro RC, Mahmoud H, Crist WM, et al
Blood 1994 Oct 15;84(8):2467-71
PMID 7919366
 
Jumping Translocations in Myeloid Malignancies Associated With Treatment Resistance and Poor Survival
Sanford D, DiNardo CD, Tang G, Cortes JE, Verstovsek S, Jabbour E, Ravandi F, Kantarjian H, Garcia-Manero G
Clin Lymphoma Myeloma Leuk 2015 Sep;15(9):556-62
PMID 26141213
 
High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia
Schmiegelow K, Lausten Thomsen U, Baruchel A, Pacheco CE, Pieters R, Pombo-de-Oliveira MS, Andersen EW, Rostgaard K, Hjalgrim H, Pui CH
Leukemia 2012 Apr;26(4):675-81
PMID 22005784
 
Cytogenetic analysis of 100 consecutive newly diagnosed cases of acute lymphoblastic leukemia in Rio de Janeiro
Silva ML, Ornellas de Souza MH, Ribeiro RC, Land MG, Boulhosa de Azevedo AM, Vasconcelos F, Otero L, Vasconcelos Z, Bouzas LF, Abdelhay E
Cancer Genet Cytogenet 2002 Sep;137(2):85-90
PMID 12393277
 
Hypodiploidy is a major prognostic factor in multiple myeloma
Smadja NV, Bastard C, Brigaudeau C, Leroux D, Fruchart C; Groupe Français de Cytogénétique Hématologique
Blood 2001 Oct 1;98(7):2229-38
PMID 11568011
 
Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization
Strefford JC, Worley H, Barber K, Wright S, Stewart AR, Robinson HM, Bettney G, van Delft FW, Atherton MG, Davies T, Griffiths M, Hing S, Ross FM, Talley P, Saha V, Moorman AV, Harrison CJ
Oncogene 2007 Jun 21;26(29):4306-18
PMID 17237825
 
Pathogenesis of jumping translocations: a molecular cytogenetics study
Wan TS, Ma SK, Chow EY, Li YH, Lin SY, Chan LC
Leuk Res 2004 Oct;28(10):1075-9
PMID 15289020
 
Additional cytogenetic abnormalities in adults with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a study of the Cancer and Leukaemia Group B
Wetzler M, Dodge RK, Mrózek K, Stewart CC, Carroll AJ, Tantravahi R, Vardiman JW, Larson RA, Bloomfield CD
Br J Haematol 2004 Feb;124(3):275-88
PMID 14717774
 
ALK-positive diffuse large B-cell lymphoma with the t(2;17)(p23;q23)
Zhang D, Denley RC, Filippa DA, Teruya-Feldstein J
Appl Immunohistochem Mol Morphol 2009 Mar;17(2):172-7
PMID 19521280
 

Citation

This paper should be referenced as such :
Zamecnikova A
der(15)t(1;15)(q11-12;p11-13) and der(15)t(1;15)(q21-25;p10-13);
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Anomalies/der15t0115ID1811.html


External links

arrayMap (UZH-SIB Zurich)Morph ( 9975/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9989/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9671/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9687/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9827/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9673/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9680/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9690/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9732/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 9 10:10:26 CEST 2018


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.